Research ExplorerPublicationsLow Homoarginine Levels in the Prognosis of Patients With Ac...

Low Homoarginine Levels in the Prognosis of Patients With Acute Chest Pain

Standard

Low Homoarginine Levels in the Prognosis of Patients With Acute Chest Pain. / Atzler, Dorothee; Baum, Christina; Ojeda, Francisco; Keller, Till; Cordts, Kathrin; Schnabel, Renate B; Choe, Chi-un; Lackner, Karl J; Münzel, Thomas; Böger, Rainer H; Blankenberg, Stefan; Schwedhelm, Edzard; Zeller, Tanja.

In: J AM HEART ASSOC, Vol. 5, No. 4, 13.04.2016, p. e002565.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Atzler, D, Baum, C, Ojeda, F, Keller, T, Cordts, K, Schnabel, RB, Choe, C, Lackner, KJ, Münzel, T, Böger, RH, Blankenberg, S, Schwedhelm, E & Zeller, T 2016, 'Low Homoarginine Levels in the Prognosis of Patients With Acute Chest Pain', J AM HEART ASSOC, vol. 5, no. 4, pp. e002565. https://doi.org/10.1161/JAHA.115.002565

APA

Atzler, D., Baum, C., Ojeda, F., Keller, T., Cordts, K., Schnabel, R. B., Choe, C., Lackner, K. J., Münzel, T., Böger, R. H., Blankenberg, S., Schwedhelm, E., & Zeller, T. (2016). Low Homoarginine Levels in the Prognosis of Patients With Acute Chest Pain. J AM HEART ASSOC, 5(4), e002565. https://doi.org/10.1161/JAHA.115.002565

Vancouver

Atzler D, Baum C, Ojeda F, Keller T, Cordts K, Schnabel RB et al. Low Homoarginine Levels in the Prognosis of Patients With Acute Chest Pain. J AM HEART ASSOC. 2016 Apr 13;5(4):e002565. https://doi.org/10.1161/JAHA.115.002565

Bibtex

@article{2ec3c2c96c4d42f48d0ab1d55bacc78c,
title = "Low Homoarginine Levels in the Prognosis of Patients With Acute Chest Pain",
abstract = "BACKGROUND: The endogenous amino acid homoarginine predicts mortality in cerebro- and cardiovascular disease. The objective was to explore whether homoarginine is associated with atrial fibrillation (AF) and outcome in patients with acute chest pain.METHODS AND RESULTS: One thousand six hundred forty-nine patients with acute chest pain were consecutively enrolled in this study, of whom 589 were diagnosed acute coronary syndrome (ACS). On admission, plasma concentrations of homoarginine as well as brain natriuretic peptide (BNP), and high-sensitivity assayed troponin I (hsTnI) were determined along with electrocardiography (ECG) variables. During a median follow-up of 183 days, 60 major adverse cardiovascular events (MACEs; 3.8%), including all-cause death, myocardial infarction, or stroke, were registered in the overall study population and 43 MACEs (7.5%) in the ACS subgroup. Adjusted multivariable Cox regression analyses revealed that an increase of 1 SD of plasma log-transformed homoarginine (0.37) was associated with a hazard reduction of 26% (hazard ratio [HR], 0.74; 95% CI, 0.57-0.96) for incident MACE and likewise of 35% (HR, 0.65; 95% CI, 0.49-0.88) in ACS patients. In Kaplan-Meier survival curves, homoarginine was predictive for patients with high-sensitivity assayed troponin I (hsTnI) above 27 ng/L (P<0.05). Last, homoarginine was inversely associated with QTc duration (P<0.001) and prevalent AF (OR, 0.83; 95% CI, 0.71-0.95).CONCLUSION: Low plasma homoarginine was identified as a risk marker for incident MACEs in patients with acute chest pain, in particular, in those with elevated hsTnI. Impaired homoarginine was associated with prevalent AF. Further studies are needed to investigate the link to AF and evaluate homoarginine as a therapeutic option for these patients.",
keywords = "Journal Article, Research Support, Non-U.S. Gov't",
author = "Dorothee Atzler and Christina Baum and Francisco Ojeda and Till Keller and Kathrin Cordts and Schnabel, {Renate B} and Chi-un Choe and Lackner, {Karl J} and Thomas M{\"u}nzel and B{\"o}ger, {Rainer H} and Stefan Blankenberg and Edzard Schwedhelm and Tanja Zeller",
note = "{\textcopyright} 2016 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.",
year = "2016",
month = apr,
day = "13",
doi = "10.1161/JAHA.115.002565",
language = "English",
volume = "5",
pages = "e002565",
journal = "J AM HEART ASSOC",
issn = "2047-9980",
publisher = "Wiley-Blackwell",
number = "4",

}

RIS

TY - JOUR

T1 - Low Homoarginine Levels in the Prognosis of Patients With Acute Chest Pain

AU - Atzler, Dorothee

AU - Baum, Christina

AU - Ojeda, Francisco

AU - Keller, Till

AU - Cordts, Kathrin

AU - Schnabel, Renate B

AU - Choe, Chi-un

AU - Lackner, Karl J

AU - Münzel, Thomas

AU - Böger, Rainer H

AU - Blankenberg, Stefan

AU - Schwedhelm, Edzard

AU - Zeller, Tanja

N1 - © 2016 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

PY - 2016/4/13

Y1 - 2016/4/13

N2 - BACKGROUND: The endogenous amino acid homoarginine predicts mortality in cerebro- and cardiovascular disease. The objective was to explore whether homoarginine is associated with atrial fibrillation (AF) and outcome in patients with acute chest pain.METHODS AND RESULTS: One thousand six hundred forty-nine patients with acute chest pain were consecutively enrolled in this study, of whom 589 were diagnosed acute coronary syndrome (ACS). On admission, plasma concentrations of homoarginine as well as brain natriuretic peptide (BNP), and high-sensitivity assayed troponin I (hsTnI) were determined along with electrocardiography (ECG) variables. During a median follow-up of 183 days, 60 major adverse cardiovascular events (MACEs; 3.8%), including all-cause death, myocardial infarction, or stroke, were registered in the overall study population and 43 MACEs (7.5%) in the ACS subgroup. Adjusted multivariable Cox regression analyses revealed that an increase of 1 SD of plasma log-transformed homoarginine (0.37) was associated with a hazard reduction of 26% (hazard ratio [HR], 0.74; 95% CI, 0.57-0.96) for incident MACE and likewise of 35% (HR, 0.65; 95% CI, 0.49-0.88) in ACS patients. In Kaplan-Meier survival curves, homoarginine was predictive for patients with high-sensitivity assayed troponin I (hsTnI) above 27 ng/L (P<0.05). Last, homoarginine was inversely associated with QTc duration (P<0.001) and prevalent AF (OR, 0.83; 95% CI, 0.71-0.95).CONCLUSION: Low plasma homoarginine was identified as a risk marker for incident MACEs in patients with acute chest pain, in particular, in those with elevated hsTnI. Impaired homoarginine was associated with prevalent AF. Further studies are needed to investigate the link to AF and evaluate homoarginine as a therapeutic option for these patients.

AB - BACKGROUND: The endogenous amino acid homoarginine predicts mortality in cerebro- and cardiovascular disease. The objective was to explore whether homoarginine is associated with atrial fibrillation (AF) and outcome in patients with acute chest pain.METHODS AND RESULTS: One thousand six hundred forty-nine patients with acute chest pain were consecutively enrolled in this study, of whom 589 were diagnosed acute coronary syndrome (ACS). On admission, plasma concentrations of homoarginine as well as brain natriuretic peptide (BNP), and high-sensitivity assayed troponin I (hsTnI) were determined along with electrocardiography (ECG) variables. During a median follow-up of 183 days, 60 major adverse cardiovascular events (MACEs; 3.8%), including all-cause death, myocardial infarction, or stroke, were registered in the overall study population and 43 MACEs (7.5%) in the ACS subgroup. Adjusted multivariable Cox regression analyses revealed that an increase of 1 SD of plasma log-transformed homoarginine (0.37) was associated with a hazard reduction of 26% (hazard ratio [HR], 0.74; 95% CI, 0.57-0.96) for incident MACE and likewise of 35% (HR, 0.65; 95% CI, 0.49-0.88) in ACS patients. In Kaplan-Meier survival curves, homoarginine was predictive for patients with high-sensitivity assayed troponin I (hsTnI) above 27 ng/L (P<0.05). Last, homoarginine was inversely associated with QTc duration (P<0.001) and prevalent AF (OR, 0.83; 95% CI, 0.71-0.95).CONCLUSION: Low plasma homoarginine was identified as a risk marker for incident MACEs in patients with acute chest pain, in particular, in those with elevated hsTnI. Impaired homoarginine was associated with prevalent AF. Further studies are needed to investigate the link to AF and evaluate homoarginine as a therapeutic option for these patients.

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1161/JAHA.115.002565

DO - 10.1161/JAHA.115.002565

M3 - SCORING: Journal article

C2 - 27076564

VL - 5

SP - e002565

JO - J AM HEART ASSOC

JF - J AM HEART ASSOC

SN - 2047-9980

IS - 4

ER -