Loudness dependence of auditory evoked potentials in patients with borderline personality disorder--impact of psychopathology.
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Loudness dependence of auditory evoked potentials in patients with borderline personality disorder--impact of psychopathology. / Schaaff, Nadine; Karch, Susanne; Segmiller, Felix; Koch, Walter; Reicherzer, Markus; Mulert, Christoph; Hegerl, Ulrich; Juckel, Georg; Pogarell, Oliver.
In: PSYCHIAT RES, Vol. 199, No. 3, 3, 2012, p. 181-187.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Loudness dependence of auditory evoked potentials in patients with borderline personality disorder--impact of psychopathology.
AU - Schaaff, Nadine
AU - Karch, Susanne
AU - Segmiller, Felix
AU - Koch, Walter
AU - Reicherzer, Markus
AU - Mulert, Christoph
AU - Hegerl, Ulrich
AU - Juckel, Georg
AU - Pogarell, Oliver
PY - 2012
Y1 - 2012
N2 - Alterations of the central serotonergic system are considered to be involved in the pathophysiology of borderline personality disorder (BPD). The loudness dependence of the N1/P2 component of auditory evoked potentials (LD) has been shown to indirectly reflect central serotonergic activity. The aim of this study was to investigate LD in patients with BPD compared to healthy controls, and to evaluate the association between LD and psychopathology such as anxiety, anger or impulsiveness. Female patients with BPD were included and compared to age- and sex-matched healthy subjects. Self-rating instruments, such as the State-Trait Anxiety Inventory (STAI), State-Trait Anger Expression Inventory (STAXI), and the Barratt Impulsiveness Scale (BIS) were used to assess clinical scores of anxiety, anger, and impulsiveness. Evoked potentials were recorded following the application of acoustic stimuli with increasing intensities; the LD was analysed using dipole source analysis. The mean LD was significantly higher in patients with BPD compared to controls. In the entire sample there were significant positive correlations of LD with state anxiety scores and STAXI subscores. The data contribute to the knowledge of neurophysiological alterations in patients with BPD, supporting the hypothesis of serotonergic dysregulation in the pathophysiology of the disorder. The significant clinical correlations suggest monoaminergic modulations of psychopathology on the symptom level.
AB - Alterations of the central serotonergic system are considered to be involved in the pathophysiology of borderline personality disorder (BPD). The loudness dependence of the N1/P2 component of auditory evoked potentials (LD) has been shown to indirectly reflect central serotonergic activity. The aim of this study was to investigate LD in patients with BPD compared to healthy controls, and to evaluate the association between LD and psychopathology such as anxiety, anger or impulsiveness. Female patients with BPD were included and compared to age- and sex-matched healthy subjects. Self-rating instruments, such as the State-Trait Anxiety Inventory (STAI), State-Trait Anger Expression Inventory (STAXI), and the Barratt Impulsiveness Scale (BIS) were used to assess clinical scores of anxiety, anger, and impulsiveness. Evoked potentials were recorded following the application of acoustic stimuli with increasing intensities; the LD was analysed using dipole source analysis. The mean LD was significantly higher in patients with BPD compared to controls. In the entire sample there were significant positive correlations of LD with state anxiety scores and STAXI subscores. The data contribute to the knowledge of neurophysiological alterations in patients with BPD, supporting the hypothesis of serotonergic dysregulation in the pathophysiology of the disorder. The significant clinical correlations suggest monoaminergic modulations of psychopathology on the symptom level.
KW - Adult
KW - Humans
KW - Female
KW - Adolescent
KW - Electroencephalography
KW - Cerebral Cortex/physiopathology
KW - Self Report
KW - Anger/physiology
KW - Acoustic Stimulation/methods
KW - Evoked Potentials, Auditory/physiology
KW - Anxiety/physiopathology/psychology
KW - Borderline Personality Disorder/physiopathology/psychology
KW - Impulsive Behavior/physiopathology/psychology
KW - Adult
KW - Humans
KW - Female
KW - Adolescent
KW - Electroencephalography
KW - Cerebral Cortex/physiopathology
KW - Self Report
KW - Anger/physiology
KW - Acoustic Stimulation/methods
KW - Evoked Potentials, Auditory/physiology
KW - Anxiety/physiopathology/psychology
KW - Borderline Personality Disorder/physiopathology/psychology
KW - Impulsive Behavior/physiopathology/psychology
M3 - SCORING: Journal article
VL - 199
SP - 181
EP - 187
JO - PSYCHIAT RES
JF - PSYCHIAT RES
SN - 0165-1781
IS - 3
M1 - 3
ER -
