Research ExplorerPublicationsLoss of RNA-binding motif protein 3 expression is associated...

Loss of RNA-binding motif protein 3 expression is associated with right-sided localization and poor prognosis in colorectal cancer

Standard

Loss of RNA-binding motif protein 3 expression is associated with right-sided localization and poor prognosis in colorectal cancer. / Melling, Nathaniel; Simon, Ronald; Mirlacher, Martina; Izbicki, Jakob R; Stahl, Phillip; Terracciano, Luigi M; Bokemeyer, Carsten; Sauter, Guido; Marx, Andreas H.

In: HISTOPATHOLOGY, Vol. 68, No. 2, 29.04.2015, p. 191-8.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Melling, N, Simon, R, Mirlacher, M, Izbicki, JR, Stahl, P, Terracciano, LM, Bokemeyer, C, Sauter, G & Marx, AH 2015, 'Loss of RNA-binding motif protein 3 expression is associated with right-sided localization and poor prognosis in colorectal cancer', HISTOPATHOLOGY, vol. 68, no. 2, pp. 191-8. https://doi.org/10.1111/his.12726

APA

Melling, N., Simon, R., Mirlacher, M., Izbicki, J. R., Stahl, P., Terracciano, L. M., Bokemeyer, C., Sauter, G., & Marx, A. H. (2015). Loss of RNA-binding motif protein 3 expression is associated with right-sided localization and poor prognosis in colorectal cancer. HISTOPATHOLOGY, 68(2), 191-8. https://doi.org/10.1111/his.12726

Vancouver

Melling N, Simon R, Mirlacher M, Izbicki JR, Stahl P, Terracciano LM et al. Loss of RNA-binding motif protein 3 expression is associated with right-sided localization and poor prognosis in colorectal cancer. HISTOPATHOLOGY. 2015 Apr 29;68(2):191-8. https://doi.org/10.1111/his.12726

Bibtex

@article{27fb73cff8cc448797568f082656fcb3,
title = "Loss of RNA-binding motif protein 3 expression is associated with right-sided localization and poor prognosis in colorectal cancer",
abstract = "AIMS: RNA-binding motif protein 3 (RBM3) has recently been suggested as a prognostic biomarker in an array of human cancers. This study aimed to examine its effects in colorectal cancers.METHODS AND RESULTS: RBM3 expression was analysed by immunohistochemistry on a tissue microarray containing 1800 colorectal cancers (CRCs). Nuclear RBM3 immunohistochemical staining was found in 95.9% of all interpretable CRCs. Loss of RBM3 expression was linked to advanced tumour stage (P < 0.0001), right-sided tumour localization (P < 0.0001), and poor prognosis (P = 0.0003). In a multivariable analysis including RBM3 staining, tumour grade, tumour stage, and nodal status, only tumour stage and nodal status proved to be independent prognostic markers (P < 0.0001 each), whereas the prognostic impact of RBM3 staining was not significant (P = 0.2655).CONCLUSIONS: Our observations indicate that loss of RBM3 expression is an unfavourable prognostic marker in CRC, and is linked to right-sided tumour localization.",
author = "Nathaniel Melling and Ronald Simon and Martina Mirlacher and Izbicki, {Jakob R} and Phillip Stahl and Terracciano, {Luigi M} and Carsten Bokemeyer and Guido Sauter and Marx, {Andreas H}",
note = "{\textcopyright} 2015 John Wiley & Sons Ltd.",
year = "2015",
month = apr,
day = "29",
doi = "10.1111/his.12726",
language = "English",
volume = "68",
pages = "191--8",
journal = "HISTOPATHOLOGY",
issn = "0309-0167",
publisher = "Wiley-Blackwell",
number = "2",

}

RIS

TY - JOUR

T1 - Loss of RNA-binding motif protein 3 expression is associated with right-sided localization and poor prognosis in colorectal cancer

AU - Melling, Nathaniel

AU - Simon, Ronald

AU - Mirlacher, Martina

AU - Izbicki, Jakob R

AU - Stahl, Phillip

AU - Terracciano, Luigi M

AU - Bokemeyer, Carsten

AU - Sauter, Guido

AU - Marx, Andreas H

N1 - © 2015 John Wiley & Sons Ltd.

PY - 2015/4/29

Y1 - 2015/4/29

N2 - AIMS: RNA-binding motif protein 3 (RBM3) has recently been suggested as a prognostic biomarker in an array of human cancers. This study aimed to examine its effects in colorectal cancers.METHODS AND RESULTS: RBM3 expression was analysed by immunohistochemistry on a tissue microarray containing 1800 colorectal cancers (CRCs). Nuclear RBM3 immunohistochemical staining was found in 95.9% of all interpretable CRCs. Loss of RBM3 expression was linked to advanced tumour stage (P < 0.0001), right-sided tumour localization (P < 0.0001), and poor prognosis (P = 0.0003). In a multivariable analysis including RBM3 staining, tumour grade, tumour stage, and nodal status, only tumour stage and nodal status proved to be independent prognostic markers (P < 0.0001 each), whereas the prognostic impact of RBM3 staining was not significant (P = 0.2655).CONCLUSIONS: Our observations indicate that loss of RBM3 expression is an unfavourable prognostic marker in CRC, and is linked to right-sided tumour localization.

AB - AIMS: RNA-binding motif protein 3 (RBM3) has recently been suggested as a prognostic biomarker in an array of human cancers. This study aimed to examine its effects in colorectal cancers.METHODS AND RESULTS: RBM3 expression was analysed by immunohistochemistry on a tissue microarray containing 1800 colorectal cancers (CRCs). Nuclear RBM3 immunohistochemical staining was found in 95.9% of all interpretable CRCs. Loss of RBM3 expression was linked to advanced tumour stage (P < 0.0001), right-sided tumour localization (P < 0.0001), and poor prognosis (P = 0.0003). In a multivariable analysis including RBM3 staining, tumour grade, tumour stage, and nodal status, only tumour stage and nodal status proved to be independent prognostic markers (P < 0.0001 each), whereas the prognostic impact of RBM3 staining was not significant (P = 0.2655).CONCLUSIONS: Our observations indicate that loss of RBM3 expression is an unfavourable prognostic marker in CRC, and is linked to right-sided tumour localization.

U2 - 10.1111/his.12726

DO - 10.1111/his.12726

M3 - SCORING: Journal article

C2 - 25922889

VL - 68

SP - 191

EP - 198

JO - HISTOPATHOLOGY

JF - HISTOPATHOLOGY

SN - 0309-0167

IS - 2

ER -