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Loss of NF1 alleles distinguish sporadic from NF1-associated pilocytic astrocytomas

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Loss of NF1 alleles distinguish sporadic from NF1-associated pilocytic astrocytomas. / Kluwe, L; Hagel, C; Tatagiba, M; Thomas, S; Stavrou, D; Ostertag, H; von Deimling, A; Mautner, V F.

In: J NEUROPATH EXP NEUR, Vol. 60, No. 9, 01.09.2001, p. 917-20.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kluwe, L, Hagel, C, Tatagiba, M, Thomas, S, Stavrou, D, Ostertag, H, von Deimling, A & Mautner, VF 2001, 'Loss of NF1 alleles distinguish sporadic from NF1-associated pilocytic astrocytomas', J NEUROPATH EXP NEUR, vol. 60, no. 9, pp. 917-20.

APA

Kluwe, L., Hagel, C., Tatagiba, M., Thomas, S., Stavrou, D., Ostertag, H., von Deimling, A., & Mautner, V. F. (2001). Loss of NF1 alleles distinguish sporadic from NF1-associated pilocytic astrocytomas. J NEUROPATH EXP NEUR, 60(9), 917-20.

Vancouver

Kluwe L, Hagel C, Tatagiba M, Thomas S, Stavrou D, Ostertag H et al. Loss of NF1 alleles distinguish sporadic from NF1-associated pilocytic astrocytomas. J NEUROPATH EXP NEUR. 2001 Sep 1;60(9):917-20.

Bibtex

@article{c1ba8e96185047c6a694b441912dd494,
title = "Loss of NF1 alleles distinguish sporadic from NF1-associated pilocytic astrocytomas",
abstract = "Pilocytic astrocytomas classified as WHO grade I typically arise in childhood and upon complete surgical removal carry a favorable prognosis. Children with neurofibromatosis 1 (NF1) have a vastly increased risk for pilocytic astrocytomas, especially for those of the optic nerve. Using 4 intragenic NF1 microsatellite markers, we examined losses of NF1 alleles on the long arm of chromosome 17 in 12 NF1-associated and 25 sporadic pilocytic astrocytomas. The TP53 gene region on the short arm of chromosome 17 was also examined in these tumors using 3 markers. Loss of 1 NF1 allele was detected in 11 of 12 (92%) informative NF1-associated pilocytic astrocytomas. In contrast, only 1 of 24 informative (4%) sporadic pilocytic astrocytomas exhibited allelic loss in the NF1 region. Among the 11 NF1-associated tumors with NF1 loss, 5 had also lost alleles on 17p. The high rate of NF1 allele loss in NF1-associated pilocytic astrocytomas suggests a tumor initiating or promoting action of the NF1 gene in these patients. On the other hand, the much lower rate of NF1-allele loss in sporadic pilocytic astrocytomas argues for only minor importance of NF1 in that patient group. The present data support different mechanisms in the formation of NF1-associated and sporadic pilocytic astrocytomas.",
keywords = "Adolescent, Adult, Alleles, Astrocytoma, Brain Neoplasms, Cerebellum, Chromosomes, Human, Pair 17, Female, Humans, Loss of Heterozygosity, Male, Microsatellite Repeats, Nerve Tissue Proteins, Neurofibromin 1, Optic Nerve, Spinal Cord, Temporal Lobe",
author = "L Kluwe and C Hagel and M Tatagiba and S Thomas and D Stavrou and H Ostertag and {von Deimling}, A and Mautner, {V F}",
year = "2001",
month = sep,
day = "1",
language = "English",
volume = "60",
pages = "917--20",
journal = "J NEUROPATH EXP NEUR",
issn = "0022-3069",
publisher = "Lippincott Williams and Wilkins",
number = "9",

}

RIS

TY - JOUR

T1 - Loss of NF1 alleles distinguish sporadic from NF1-associated pilocytic astrocytomas

AU - Kluwe, L

AU - Hagel, C

AU - Tatagiba, M

AU - Thomas, S

AU - Stavrou, D

AU - Ostertag, H

AU - von Deimling, A

AU - Mautner, V F

PY - 2001/9/1

Y1 - 2001/9/1

N2 - Pilocytic astrocytomas classified as WHO grade I typically arise in childhood and upon complete surgical removal carry a favorable prognosis. Children with neurofibromatosis 1 (NF1) have a vastly increased risk for pilocytic astrocytomas, especially for those of the optic nerve. Using 4 intragenic NF1 microsatellite markers, we examined losses of NF1 alleles on the long arm of chromosome 17 in 12 NF1-associated and 25 sporadic pilocytic astrocytomas. The TP53 gene region on the short arm of chromosome 17 was also examined in these tumors using 3 markers. Loss of 1 NF1 allele was detected in 11 of 12 (92%) informative NF1-associated pilocytic astrocytomas. In contrast, only 1 of 24 informative (4%) sporadic pilocytic astrocytomas exhibited allelic loss in the NF1 region. Among the 11 NF1-associated tumors with NF1 loss, 5 had also lost alleles on 17p. The high rate of NF1 allele loss in NF1-associated pilocytic astrocytomas suggests a tumor initiating or promoting action of the NF1 gene in these patients. On the other hand, the much lower rate of NF1-allele loss in sporadic pilocytic astrocytomas argues for only minor importance of NF1 in that patient group. The present data support different mechanisms in the formation of NF1-associated and sporadic pilocytic astrocytomas.

AB - Pilocytic astrocytomas classified as WHO grade I typically arise in childhood and upon complete surgical removal carry a favorable prognosis. Children with neurofibromatosis 1 (NF1) have a vastly increased risk for pilocytic astrocytomas, especially for those of the optic nerve. Using 4 intragenic NF1 microsatellite markers, we examined losses of NF1 alleles on the long arm of chromosome 17 in 12 NF1-associated and 25 sporadic pilocytic astrocytomas. The TP53 gene region on the short arm of chromosome 17 was also examined in these tumors using 3 markers. Loss of 1 NF1 allele was detected in 11 of 12 (92%) informative NF1-associated pilocytic astrocytomas. In contrast, only 1 of 24 informative (4%) sporadic pilocytic astrocytomas exhibited allelic loss in the NF1 region. Among the 11 NF1-associated tumors with NF1 loss, 5 had also lost alleles on 17p. The high rate of NF1 allele loss in NF1-associated pilocytic astrocytomas suggests a tumor initiating or promoting action of the NF1 gene in these patients. On the other hand, the much lower rate of NF1-allele loss in sporadic pilocytic astrocytomas argues for only minor importance of NF1 in that patient group. The present data support different mechanisms in the formation of NF1-associated and sporadic pilocytic astrocytomas.

KW - Adolescent

KW - Adult

KW - Alleles

KW - Astrocytoma

KW - Brain Neoplasms

KW - Cerebellum

KW - Chromosomes, Human, Pair 17

KW - Female

KW - Humans

KW - Loss of Heterozygosity

KW - Male

KW - Microsatellite Repeats

KW - Nerve Tissue Proteins

KW - Neurofibromin 1

KW - Optic Nerve

KW - Spinal Cord

KW - Temporal Lobe

M3 - SCORING: Journal article

C2 - 11556548

VL - 60

SP - 917

EP - 920

JO - J NEUROPATH EXP NEUR

JF - J NEUROPATH EXP NEUR

SN - 0022-3069

IS - 9

ER -