Loss of heterozygosity at tumor suppressor genes detectable on fractionated circulating cell-free tumor DNA as indicator of breast cancer progression.
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Loss of heterozygosity at tumor suppressor genes detectable on fractionated circulating cell-free tumor DNA as indicator of breast cancer progression. / Schwarzenbach, Heidi; Eichelser, Corinna; Kropidlowski, Jolanthe; Janni, Wolfgang; Rack, Brigitte; Pantel, Klaus.
In: CLIN CANCER RES, Vol. 18, No. 20, 20, 2012, p. 5719-5730.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Loss of heterozygosity at tumor suppressor genes detectable on fractionated circulating cell-free tumor DNA as indicator of breast cancer progression.
AU - Schwarzenbach, Heidi
AU - Eichelser, Corinna
AU - Kropidlowski, Jolanthe
AU - Janni, Wolfgang
AU - Rack, Brigitte
AU - Pantel, Klaus
PY - 2012
Y1 - 2012
N2 - LOH on circulating DNA may provide tumor-specific information on breast cancer. As identification of LOH on cell-free DNA is impeded by the prevalence of wild type DNA in blood of cancer patients, we fractionated plasma DNA, and determined the diagnostic and prognostic value of both fractions.
AB - LOH on circulating DNA may provide tumor-specific information on breast cancer. As identification of LOH on cell-free DNA is impeded by the prevalence of wild type DNA in blood of cancer patients, we fractionated plasma DNA, and determined the diagnostic and prognostic value of both fractions.
KW - Adult
KW - Humans
KW - Aged
KW - Female
KW - Middle Aged
KW - Survival Analysis
KW - Disease Progression
KW - Clinical Trials as Topic
KW - Neoplasm Staging
KW - Kaplan-Meier Estimate
KW - Microsatellite Repeats/genetics
KW - Neoplastic Cells, Circulating
KW - Breast Neoplasms/blood/genetics/pathology
KW - DNA, Neoplasm/blood/genetics
KW - Loss of Heterozygosity/genetics
KW - Lymphatic Metastasis/genetics/pathology
KW - Prognosis
KW - Adult
KW - Humans
KW - Aged
KW - Female
KW - Middle Aged
KW - Survival Analysis
KW - Disease Progression
KW - Clinical Trials as Topic
KW - Neoplasm Staging
KW - Kaplan-Meier Estimate
KW - Microsatellite Repeats/genetics
KW - Neoplastic Cells, Circulating
KW - Breast Neoplasms/blood/genetics/pathology
KW - DNA, Neoplasm/blood/genetics
KW - Loss of Heterozygosity/genetics
KW - Lymphatic Metastasis/genetics/pathology
KW - Prognosis
M3 - SCORING: Journal article
VL - 18
SP - 5719
EP - 5730
JO - CLIN CANCER RES
JF - CLIN CANCER RES
SN - 1078-0432
IS - 20
M1 - 20
ER -