Research ExplorerPublicationsLong-term recurrence of neoplasia and Barrett's epithelium a...

Long-term recurrence of neoplasia and Barrett's epithelium after complete endoscopic resection

Standard

Long-term recurrence of neoplasia and Barrett's epithelium after complete endoscopic resection. / Anders, Mario; Bähr, Christina; El-Masry, Muhammad Abbas; Marx, Andreas H; Koch, Martin; Seewald, Stefan; Schachschal, Guido; Adler, Andreas; Soehendra, Nib; Izbicki, Jakob; Neuhaus, Peter; Pohl, Heiko; Rösch, Thomas.

In: GUT, Vol. 63, No. 10, 2014, p. 1535-1543.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Anders, M, Bähr, C, El-Masry, MA, Marx, AH, Koch, M, Seewald, S, Schachschal, G, Adler, A, Soehendra, N, Izbicki, J, Neuhaus, P, Pohl, H & Rösch, T 2014, 'Long-term recurrence of neoplasia and Barrett's epithelium after complete endoscopic resection', GUT, vol. 63, no. 10, pp. 1535-1543. https://doi.org/10.1136/gutjnl-2013-305538

APA

Anders, M., Bähr, C., El-Masry, M. A., Marx, A. H., Koch, M., Seewald, S., Schachschal, G., Adler, A., Soehendra, N., Izbicki, J., Neuhaus, P., Pohl, H., & Rösch, T. (2014). Long-term recurrence of neoplasia and Barrett's epithelium after complete endoscopic resection. GUT, 63(10), 1535-1543. https://doi.org/10.1136/gutjnl-2013-305538

Vancouver

Anders M, Bähr C, El-Masry MA, Marx AH, Koch M, Seewald S et al. Long-term recurrence of neoplasia and Barrett's epithelium after complete endoscopic resection. GUT. 2014;63(10):1535-1543. https://doi.org/10.1136/gutjnl-2013-305538

Bibtex

@article{b7883ed459924dfaadcdfd86455b66e0,
title = "Long-term recurrence of neoplasia and Barrett's epithelium after complete endoscopic resection",
abstract = "BACKGROUND: Current endoscopic therapy for neoplastic Barrett's oesophagus (BO) consists of complete resection/ablation of all Barrett's tissue including neoplastic lesions. Recurrence seems to be frequent after thermal therapy, such as radiofrequency ablation.OBJECTIVE: To analyse long-term recurrence of neoplasia and BO after successful widespread endoscopic mucosal resection (EMR).DESIGN: In a retrospective analysis, all patients undergoing widespread EMR of neoplastic BO between 2002 and 2007 at two referral centres were followed for at least 3 years after completion of endotherapy. Recurrence was diagnosed if neoplasia and/or BO were detected following previous successful complete removal, defined as at least two negative endoscopies and biopsies.RESULTS: Ninety patients undergoing widespread EMR were included (mean age 63 years; 82 male), 58% of whom underwent additional thermal ablation for minor residual disease. Complete eradication of neoplasia and Barrett's tissue was achieved in 90% of patients. On further follow-up (mean 64.8 months), recurrence of neoplastic and non-neoplastic BO was found in 6.2% and 39.5%, respectively. Recurring neoplasia (3 adenocarcinomas, 1 low-grade and 1 high-grade dysplasia) were found after a median of 44 months (range 38-85) and could be retreated endoscopically. In a multivariate analysis, Barrett's length was the only factor significantly associated with recurrence (OR 2.73).CONCLUSIONS: Even after seemingly complete endoscopic resection, recurrence of BO is frequent and independent of additional thermal therapy. Due to the possibility of neoplasia recurrence even after long disease-free intervals, follow-up should be extended beyond 5 years.",
author = "Mario Anders and Christina B{\"a}hr and El-Masry, {Muhammad Abbas} and Marx, {Andreas H} and Martin Koch and Stefan Seewald and Guido Schachschal and Andreas Adler and Nib Soehendra and Jakob Izbicki and Peter Neuhaus and Heiko Pohl and Thomas R{\"o}sch",
year = "2014",
doi = "10.1136/gutjnl-2013-305538",
language = "English",
volume = "63",
pages = "1535--1543",
journal = "GUT",
issn = "0017-5749",
publisher = "BMJ PUBLISHING GROUP",
number = "10",

}

RIS

TY - JOUR

T1 - Long-term recurrence of neoplasia and Barrett's epithelium after complete endoscopic resection

AU - Anders, Mario

AU - Bähr, Christina

AU - El-Masry, Muhammad Abbas

AU - Marx, Andreas H

AU - Koch, Martin

AU - Seewald, Stefan

AU - Schachschal, Guido

AU - Adler, Andreas

AU - Soehendra, Nib

AU - Izbicki, Jakob

AU - Neuhaus, Peter

AU - Pohl, Heiko

AU - Rösch, Thomas

PY - 2014

Y1 - 2014

N2 - BACKGROUND: Current endoscopic therapy for neoplastic Barrett's oesophagus (BO) consists of complete resection/ablation of all Barrett's tissue including neoplastic lesions. Recurrence seems to be frequent after thermal therapy, such as radiofrequency ablation.OBJECTIVE: To analyse long-term recurrence of neoplasia and BO after successful widespread endoscopic mucosal resection (EMR).DESIGN: In a retrospective analysis, all patients undergoing widespread EMR of neoplastic BO between 2002 and 2007 at two referral centres were followed for at least 3 years after completion of endotherapy. Recurrence was diagnosed if neoplasia and/or BO were detected following previous successful complete removal, defined as at least two negative endoscopies and biopsies.RESULTS: Ninety patients undergoing widespread EMR were included (mean age 63 years; 82 male), 58% of whom underwent additional thermal ablation for minor residual disease. Complete eradication of neoplasia and Barrett's tissue was achieved in 90% of patients. On further follow-up (mean 64.8 months), recurrence of neoplastic and non-neoplastic BO was found in 6.2% and 39.5%, respectively. Recurring neoplasia (3 adenocarcinomas, 1 low-grade and 1 high-grade dysplasia) were found after a median of 44 months (range 38-85) and could be retreated endoscopically. In a multivariate analysis, Barrett's length was the only factor significantly associated with recurrence (OR 2.73).CONCLUSIONS: Even after seemingly complete endoscopic resection, recurrence of BO is frequent and independent of additional thermal therapy. Due to the possibility of neoplasia recurrence even after long disease-free intervals, follow-up should be extended beyond 5 years.

AB - BACKGROUND: Current endoscopic therapy for neoplastic Barrett's oesophagus (BO) consists of complete resection/ablation of all Barrett's tissue including neoplastic lesions. Recurrence seems to be frequent after thermal therapy, such as radiofrequency ablation.OBJECTIVE: To analyse long-term recurrence of neoplasia and BO after successful widespread endoscopic mucosal resection (EMR).DESIGN: In a retrospective analysis, all patients undergoing widespread EMR of neoplastic BO between 2002 and 2007 at two referral centres were followed for at least 3 years after completion of endotherapy. Recurrence was diagnosed if neoplasia and/or BO were detected following previous successful complete removal, defined as at least two negative endoscopies and biopsies.RESULTS: Ninety patients undergoing widespread EMR were included (mean age 63 years; 82 male), 58% of whom underwent additional thermal ablation for minor residual disease. Complete eradication of neoplasia and Barrett's tissue was achieved in 90% of patients. On further follow-up (mean 64.8 months), recurrence of neoplastic and non-neoplastic BO was found in 6.2% and 39.5%, respectively. Recurring neoplasia (3 adenocarcinomas, 1 low-grade and 1 high-grade dysplasia) were found after a median of 44 months (range 38-85) and could be retreated endoscopically. In a multivariate analysis, Barrett's length was the only factor significantly associated with recurrence (OR 2.73).CONCLUSIONS: Even after seemingly complete endoscopic resection, recurrence of BO is frequent and independent of additional thermal therapy. Due to the possibility of neoplasia recurrence even after long disease-free intervals, follow-up should be extended beyond 5 years.

U2 - 10.1136/gutjnl-2013-305538

DO - 10.1136/gutjnl-2013-305538

M3 - SCORING: Journal article

C2 - 24389236

VL - 63

SP - 1535

EP - 1543

JO - GUT

JF - GUT

SN - 0017-5749

IS - 10

ER -