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Long-term outcome of liver transplantation for autoimmune hepatitis.

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Long-term outcome of liver transplantation for autoimmune hepatitis. / Vogel, Arndt; Heinrich, Eyk; Bahr, Matthias J; Rifai, Kinan; Flemming, Peer; Melter, Michael; Klempnauer, Juergen; Nashan, Björn; Manns, Michael P; Strassburg, Christian P.

In: CLIN TRANSPLANT, Vol. 18, No. 1, 1, 2004, p. 62-69.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Vogel, A, Heinrich, E, Bahr, MJ, Rifai, K, Flemming, P, Melter, M, Klempnauer, J, Nashan, B, Manns, MP & Strassburg, CP 2004, 'Long-term outcome of liver transplantation for autoimmune hepatitis.', CLIN TRANSPLANT, vol. 18, no. 1, 1, pp. 62-69. <http://www.ncbi.nlm.nih.gov/pubmed/15108772?dopt=Citation>

APA

Vogel, A., Heinrich, E., Bahr, M. J., Rifai, K., Flemming, P., Melter, M., Klempnauer, J., Nashan, B., Manns, M. P., & Strassburg, C. P. (2004). Long-term outcome of liver transplantation for autoimmune hepatitis. CLIN TRANSPLANT, 18(1), 62-69. [1]. http://www.ncbi.nlm.nih.gov/pubmed/15108772?dopt=Citation

Vancouver

Vogel A, Heinrich E, Bahr MJ, Rifai K, Flemming P, Melter M et al. Long-term outcome of liver transplantation for autoimmune hepatitis. CLIN TRANSPLANT. 2004;18(1):62-69. 1.

Bibtex

@article{7df13c7b1dea4438b09365c1523a92e0,
title = "Long-term outcome of liver transplantation for autoimmune hepatitis.",
abstract = "BACKGROUND: Liver transplantation is the final therapeutic option for about 10% of patients with autoimmune hepatitis (AIH) who do not respond to medical therapy. The aim of this study was to evaluate the long-term outcome in serologically defined subgroups of AIH after transplantation. METHODS: Pre- and post-transplantation data of 28 patients with AIH transplanted between 1987 and 1999 were retrospectively analyzed and compared with 24 patients, who underwent liver transplantation because of Wilson's disease and glycogen storage disease type 1. RESULTS: Serological analyses identified patients with AIH type 1 (n = 13), type 2 (n = 5), and type 3 (n = 10). The 5-yr patient survival rate after liver transplantation was 78.2%, which was not significantly different from the control group. Six AIH patients and four control patients required re-transplantation because of initial non-function, chronic rejection or AIH recurrence. Patients transplanted for AIH (88%) had more episodes of acute rejection when compared with patients transplanted for genetic liver diseases (50%). Clinical and histological features of chronic rejection were present in four patients, which did not differ significantly from the controls. Recurrence of AIH was diagnosed in nine patients (32%) based upon the presence of autoantibodies, increased gamma-globulins, steroid dependency, and histological evidence of chronic hepatitis. These combined features were not found in any of the controls. CONCLUSIONS: Our data do not suggest that AIH subtypes influence prognosis after liver transplantation. Despite a high frequency of acute cellular rejection episodes and disease recurrence, transplantation for AIH has a 5-yr survival rate, which does not differ from that observed in patients transplanted for genetic liver diseases.",
author = "Arndt Vogel and Eyk Heinrich and Bahr, {Matthias J} and Kinan Rifai and Peer Flemming and Michael Melter and Juergen Klempnauer and Bj{\"o}rn Nashan and Manns, {Michael P} and Strassburg, {Christian P}",
year = "2004",
language = "Deutsch",
volume = "18",
pages = "62--69",
journal = "CLIN TRANSPLANT",
issn = "0902-0063",
publisher = "Wiley-Blackwell",
number = "1",

}

RIS

TY - JOUR

T1 - Long-term outcome of liver transplantation for autoimmune hepatitis.

AU - Vogel, Arndt

AU - Heinrich, Eyk

AU - Bahr, Matthias J

AU - Rifai, Kinan

AU - Flemming, Peer

AU - Melter, Michael

AU - Klempnauer, Juergen

AU - Nashan, Björn

AU - Manns, Michael P

AU - Strassburg, Christian P

PY - 2004

Y1 - 2004

N2 - BACKGROUND: Liver transplantation is the final therapeutic option for about 10% of patients with autoimmune hepatitis (AIH) who do not respond to medical therapy. The aim of this study was to evaluate the long-term outcome in serologically defined subgroups of AIH after transplantation. METHODS: Pre- and post-transplantation data of 28 patients with AIH transplanted between 1987 and 1999 were retrospectively analyzed and compared with 24 patients, who underwent liver transplantation because of Wilson's disease and glycogen storage disease type 1. RESULTS: Serological analyses identified patients with AIH type 1 (n = 13), type 2 (n = 5), and type 3 (n = 10). The 5-yr patient survival rate after liver transplantation was 78.2%, which was not significantly different from the control group. Six AIH patients and four control patients required re-transplantation because of initial non-function, chronic rejection or AIH recurrence. Patients transplanted for AIH (88%) had more episodes of acute rejection when compared with patients transplanted for genetic liver diseases (50%). Clinical and histological features of chronic rejection were present in four patients, which did not differ significantly from the controls. Recurrence of AIH was diagnosed in nine patients (32%) based upon the presence of autoantibodies, increased gamma-globulins, steroid dependency, and histological evidence of chronic hepatitis. These combined features were not found in any of the controls. CONCLUSIONS: Our data do not suggest that AIH subtypes influence prognosis after liver transplantation. Despite a high frequency of acute cellular rejection episodes and disease recurrence, transplantation for AIH has a 5-yr survival rate, which does not differ from that observed in patients transplanted for genetic liver diseases.

AB - BACKGROUND: Liver transplantation is the final therapeutic option for about 10% of patients with autoimmune hepatitis (AIH) who do not respond to medical therapy. The aim of this study was to evaluate the long-term outcome in serologically defined subgroups of AIH after transplantation. METHODS: Pre- and post-transplantation data of 28 patients with AIH transplanted between 1987 and 1999 were retrospectively analyzed and compared with 24 patients, who underwent liver transplantation because of Wilson's disease and glycogen storage disease type 1. RESULTS: Serological analyses identified patients with AIH type 1 (n = 13), type 2 (n = 5), and type 3 (n = 10). The 5-yr patient survival rate after liver transplantation was 78.2%, which was not significantly different from the control group. Six AIH patients and four control patients required re-transplantation because of initial non-function, chronic rejection or AIH recurrence. Patients transplanted for AIH (88%) had more episodes of acute rejection when compared with patients transplanted for genetic liver diseases (50%). Clinical and histological features of chronic rejection were present in four patients, which did not differ significantly from the controls. Recurrence of AIH was diagnosed in nine patients (32%) based upon the presence of autoantibodies, increased gamma-globulins, steroid dependency, and histological evidence of chronic hepatitis. These combined features were not found in any of the controls. CONCLUSIONS: Our data do not suggest that AIH subtypes influence prognosis after liver transplantation. Despite a high frequency of acute cellular rejection episodes and disease recurrence, transplantation for AIH has a 5-yr survival rate, which does not differ from that observed in patients transplanted for genetic liver diseases.

M3 - SCORING: Zeitschriftenaufsatz

VL - 18

SP - 62

EP - 69

JO - CLIN TRANSPLANT

JF - CLIN TRANSPLANT

SN - 0902-0063

IS - 1

M1 - 1

ER -