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Long-term insulin-secretory function of islets of Langerhans encapsulated with a layer of confluent chondrocytes for immunoisolation.

Standard

Long-term insulin-secretory function of islets of Langerhans encapsulated with a layer of confluent chondrocytes for immunoisolation. / Pollok, Jörg-Matthias; Begemann, J F; Kaufmann, P M; Kluth, D; Broelsch, C E; Izbicki, J R; Rogiers, X.

In: PEDIATR SURG INT, Vol. 15, No. 3-4, 3-4, 1999, p. 164-167.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Pollok, J-M, Begemann, JF, Kaufmann, PM, Kluth, D, Broelsch, CE, Izbicki, JR & Rogiers, X 1999, 'Long-term insulin-secretory function of islets of Langerhans encapsulated with a layer of confluent chondrocytes for immunoisolation.', PEDIATR SURG INT, vol. 15, no. 3-4, 3-4, pp. 164-167. <http://www.ncbi.nlm.nih.gov/pubmed/10370014?dopt=Citation>

APA

Pollok, J-M., Begemann, J. F., Kaufmann, P. M., Kluth, D., Broelsch, C. E., Izbicki, J. R., & Rogiers, X. (1999). Long-term insulin-secretory function of islets of Langerhans encapsulated with a layer of confluent chondrocytes for immunoisolation. PEDIATR SURG INT, 15(3-4), 164-167. [3-4]. http://www.ncbi.nlm.nih.gov/pubmed/10370014?dopt=Citation

Vancouver

Pollok J-M, Begemann JF, Kaufmann PM, Kluth D, Broelsch CE, Izbicki JR et al. Long-term insulin-secretory function of islets of Langerhans encapsulated with a layer of confluent chondrocytes for immunoisolation. PEDIATR SURG INT. 1999;15(3-4):164-167. 3-4.

Bibtex

@article{1a3febe0145c4e93ae65fe9e75f3e362,
title = "Long-term insulin-secretory function of islets of Langerhans encapsulated with a layer of confluent chondrocytes for immunoisolation.",
abstract = "Islet transplantation is a potential cure for diabetes mellitus. The major problem for broad clinical application remains the prevention of transplant rejection without major side effects. Immunoisolation is an experimental strategy to prevent rejection by separating the transplanted cells from the host immune system using a barrier device. Current methods use artificial, not completely inert materials as barrier devices and induce an unwanted foreign-body (FB) reaction. Using the recipients of own cells for encapsulation, the FB reaction could be prevented. This study describes a new method of encapsulation of islets of Langerhans within a capsule of chondrocytes, which may serve as an immunoisolation barrier utilizing the immunoprivileged properties of the chrondrocyte matrix, and demonstrates the functional survival of the encapsulated islets in vitro.",
author = "J{\"o}rg-Matthias Pollok and Begemann, {J F} and Kaufmann, {P M} and D Kluth and Broelsch, {C E} and Izbicki, {J R} and X Rogiers",
year = "1999",
language = "Deutsch",
volume = "15",
pages = "164--167",
journal = "PEDIATR SURG INT",
issn = "0179-0358",
publisher = "Springer",
number = "3-4",

}

RIS

TY - JOUR

T1 - Long-term insulin-secretory function of islets of Langerhans encapsulated with a layer of confluent chondrocytes for immunoisolation.

AU - Pollok, Jörg-Matthias

AU - Begemann, J F

AU - Kaufmann, P M

AU - Kluth, D

AU - Broelsch, C E

AU - Izbicki, J R

AU - Rogiers, X

PY - 1999

Y1 - 1999

N2 - Islet transplantation is a potential cure for diabetes mellitus. The major problem for broad clinical application remains the prevention of transplant rejection without major side effects. Immunoisolation is an experimental strategy to prevent rejection by separating the transplanted cells from the host immune system using a barrier device. Current methods use artificial, not completely inert materials as barrier devices and induce an unwanted foreign-body (FB) reaction. Using the recipients of own cells for encapsulation, the FB reaction could be prevented. This study describes a new method of encapsulation of islets of Langerhans within a capsule of chondrocytes, which may serve as an immunoisolation barrier utilizing the immunoprivileged properties of the chrondrocyte matrix, and demonstrates the functional survival of the encapsulated islets in vitro.

AB - Islet transplantation is a potential cure for diabetes mellitus. The major problem for broad clinical application remains the prevention of transplant rejection without major side effects. Immunoisolation is an experimental strategy to prevent rejection by separating the transplanted cells from the host immune system using a barrier device. Current methods use artificial, not completely inert materials as barrier devices and induce an unwanted foreign-body (FB) reaction. Using the recipients of own cells for encapsulation, the FB reaction could be prevented. This study describes a new method of encapsulation of islets of Langerhans within a capsule of chondrocytes, which may serve as an immunoisolation barrier utilizing the immunoprivileged properties of the chrondrocyte matrix, and demonstrates the functional survival of the encapsulated islets in vitro.

M3 - SCORING: Zeitschriftenaufsatz

VL - 15

SP - 164

EP - 167

JO - PEDIATR SURG INT

JF - PEDIATR SURG INT

SN - 0179-0358

IS - 3-4

M1 - 3-4

ER -