Long-term follow-up of gastric MALT lymphoma after H. pylori eradication
Standard
Long-term follow-up of gastric MALT lymphoma after H. pylori eradication. / Morgner, A; Thiede, C; Bayerdörffer, E; Alpen, B; Wündisch, T; Neubauer, A; Stolte, M.
In: Curr Gastroenterol Rep, Vol. 3, No. 6, 12.2001, p. 516-22.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Long-term follow-up of gastric MALT lymphoma after H. pylori eradication
AU - Morgner, A
AU - Thiede, C
AU - Bayerdörffer, E
AU - Alpen, B
AU - Wündisch, T
AU - Neubauer, A
AU - Stolte, M
PY - 2001/12
Y1 - 2001/12
N2 - For almost 10 years, we have been familiar with the concept of mucosa-associated lymphoid tissue (MALT)-type lymphoma of the stomach caused by chronic Helicobacter pylori infection. Many epidemiologic, biologic, and molecular genetic studies have implicated H. pylori for its role in lymphoma genesis. Since the first reports on complete remission of gastric MALT lymphomas after cure of bacterial infection, many clinical studies have investigated the effect of eradicating H. pylori on the course of MALT lymphoma, and indeed were able to confirm remission of the lymphoma. To date, more than 650 patients worldwide have been treated for gastric MALT lymphoma with antibiotics, and we have gained many new insights concerning the biologic behavior of this disease, especially from the deepened knowledge of cytogenetics. Furthermore, factors relevant for the prediction of treatment outcome have been identified, which has helped to stratify patients into risk groups.
AB - For almost 10 years, we have been familiar with the concept of mucosa-associated lymphoid tissue (MALT)-type lymphoma of the stomach caused by chronic Helicobacter pylori infection. Many epidemiologic, biologic, and molecular genetic studies have implicated H. pylori for its role in lymphoma genesis. Since the first reports on complete remission of gastric MALT lymphomas after cure of bacterial infection, many clinical studies have investigated the effect of eradicating H. pylori on the course of MALT lymphoma, and indeed were able to confirm remission of the lymphoma. To date, more than 650 patients worldwide have been treated for gastric MALT lymphoma with antibiotics, and we have gained many new insights concerning the biologic behavior of this disease, especially from the deepened knowledge of cytogenetics. Furthermore, factors relevant for the prediction of treatment outcome have been identified, which has helped to stratify patients into risk groups.
KW - Follow-Up Studies
KW - Helicobacter Infections
KW - Helicobacter pylori
KW - Humans
KW - Lymphoma, B-Cell, Marginal Zone
KW - Stomach Neoplasms
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
KW - Review
M3 - SCORING: Journal article
C2 - 11696290
VL - 3
SP - 516
EP - 522
JO - Curr Gastroenterol Rep
JF - Curr Gastroenterol Rep
SN - 1522-8037
IS - 6
ER -