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Long-term effects of enriched environment on neurofunctional outcome and CNS lesion volume after traumatic brain injury in rats

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Long-term effects of enriched environment on neurofunctional outcome and CNS lesion volume after traumatic brain injury in rats. / Maegele, M; Braun, M; Wafaisade, A; Schäfer, N; Lippert-Gruener, M; Kreipke, C; Rafols, J; Schäfer, U; Angelov, D N; Stuermer, E K.

In: PHYSIOL RES, Vol. 64, No. 1, 2015, p. 129-45.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Maegele, M, Braun, M, Wafaisade, A, Schäfer, N, Lippert-Gruener, M, Kreipke, C, Rafols, J, Schäfer, U, Angelov, DN & Stuermer, EK 2015, 'Long-term effects of enriched environment on neurofunctional outcome and CNS lesion volume after traumatic brain injury in rats', PHYSIOL RES, vol. 64, no. 1, pp. 129-45. https://doi.org/10.33549/physiolres.932664

APA

Maegele, M., Braun, M., Wafaisade, A., Schäfer, N., Lippert-Gruener, M., Kreipke, C., Rafols, J., Schäfer, U., Angelov, D. N., & Stuermer, E. K. (2015). Long-term effects of enriched environment on neurofunctional outcome and CNS lesion volume after traumatic brain injury in rats. PHYSIOL RES, 64(1), 129-45. https://doi.org/10.33549/physiolres.932664

Vancouver

Maegele M, Braun M, Wafaisade A, Schäfer N, Lippert-Gruener M, Kreipke C et al. Long-term effects of enriched environment on neurofunctional outcome and CNS lesion volume after traumatic brain injury in rats. PHYSIOL RES. 2015;64(1):129-45. https://doi.org/10.33549/physiolres.932664

Bibtex

@article{01a0ab06c3674265af5f4666e66eeb9e,
title = "Long-term effects of enriched environment on neurofunctional outcome and CNS lesion volume after traumatic brain injury in rats",
abstract = "To determine whether the exposure to long term enriched environment (EE) would result in a continuous improvement of neurological recovery and ameliorate the loss of brain tissue after traumatic brain injury (TBI) vs. standard housing (SH). Male Sprague-Dawley rats (300-350 g, n=28) underwent lateral fluid percussion brain injury or SHAM operation. One TBI group was held under complex EE for 90 days, the other under SH. Neuromotor and sensorimotor dysfunction and recovery were assessed after injury and at days 7, 15, and 90 via Composite Neuroscore (NS), RotaRod test, and Barnes Circular Maze (BCM). Cortical tissue loss was assessed using serial brain sections. After day 7 EE animals showed similar latencies and errors as SHAM in the BCM. SH animals performed notably worse with differences still significant on day 90 (p<0.001). RotaRod test and NS revealed superior results for EE animals after day 7. The mean cortical volume was significantly higher in EE vs. SH animals (p=0.003). In summary, EE animals after lateral fluid percussion (LFP) brain injury performed significantly better than SH animals after 90 days of recovery. The window of opportunity may be wide and also lends further credibility to the importance of long term interventions in patients suffering from TBI.",
keywords = "Animals, Behavior, Animal, Brain Injuries/pathology, Disease Models, Animal, Environment, Controlled, Housing, Animal, Male, Maze Learning, Motor Activity, Nerve Regeneration, Organ Size, Rats, Sprague-Dawley, Recovery of Function, Rotarod Performance Test, Sensorimotor Cortex/pathology, Spatial Behavior, Time Factors",
author = "M Maegele and M Braun and A Wafaisade and N Sch{\"a}fer and M Lippert-Gruener and C Kreipke and J Rafols and U Sch{\"a}fer and Angelov, {D N} and Stuermer, {E K}",
year = "2015",
doi = "10.33549/physiolres.932664",
language = "English",
volume = "64",
pages = "129--45",
journal = "PHYSIOL RES",
issn = "0862-8408",
publisher = "Czech Academy of Sciences",
number = "1",

}

RIS

TY - JOUR

T1 - Long-term effects of enriched environment on neurofunctional outcome and CNS lesion volume after traumatic brain injury in rats

AU - Maegele, M

AU - Braun, M

AU - Wafaisade, A

AU - Schäfer, N

AU - Lippert-Gruener, M

AU - Kreipke, C

AU - Rafols, J

AU - Schäfer, U

AU - Angelov, D N

AU - Stuermer, E K

PY - 2015

Y1 - 2015

N2 - To determine whether the exposure to long term enriched environment (EE) would result in a continuous improvement of neurological recovery and ameliorate the loss of brain tissue after traumatic brain injury (TBI) vs. standard housing (SH). Male Sprague-Dawley rats (300-350 g, n=28) underwent lateral fluid percussion brain injury or SHAM operation. One TBI group was held under complex EE for 90 days, the other under SH. Neuromotor and sensorimotor dysfunction and recovery were assessed after injury and at days 7, 15, and 90 via Composite Neuroscore (NS), RotaRod test, and Barnes Circular Maze (BCM). Cortical tissue loss was assessed using serial brain sections. After day 7 EE animals showed similar latencies and errors as SHAM in the BCM. SH animals performed notably worse with differences still significant on day 90 (p<0.001). RotaRod test and NS revealed superior results for EE animals after day 7. The mean cortical volume was significantly higher in EE vs. SH animals (p=0.003). In summary, EE animals after lateral fluid percussion (LFP) brain injury performed significantly better than SH animals after 90 days of recovery. The window of opportunity may be wide and also lends further credibility to the importance of long term interventions in patients suffering from TBI.

AB - To determine whether the exposure to long term enriched environment (EE) would result in a continuous improvement of neurological recovery and ameliorate the loss of brain tissue after traumatic brain injury (TBI) vs. standard housing (SH). Male Sprague-Dawley rats (300-350 g, n=28) underwent lateral fluid percussion brain injury or SHAM operation. One TBI group was held under complex EE for 90 days, the other under SH. Neuromotor and sensorimotor dysfunction and recovery were assessed after injury and at days 7, 15, and 90 via Composite Neuroscore (NS), RotaRod test, and Barnes Circular Maze (BCM). Cortical tissue loss was assessed using serial brain sections. After day 7 EE animals showed similar latencies and errors as SHAM in the BCM. SH animals performed notably worse with differences still significant on day 90 (p<0.001). RotaRod test and NS revealed superior results for EE animals after day 7. The mean cortical volume was significantly higher in EE vs. SH animals (p=0.003). In summary, EE animals after lateral fluid percussion (LFP) brain injury performed significantly better than SH animals after 90 days of recovery. The window of opportunity may be wide and also lends further credibility to the importance of long term interventions in patients suffering from TBI.

KW - Animals

KW - Behavior, Animal

KW - Brain Injuries/pathology

KW - Disease Models, Animal

KW - Environment, Controlled

KW - Housing, Animal

KW - Male

KW - Maze Learning

KW - Motor Activity

KW - Nerve Regeneration

KW - Organ Size

KW - Rats, Sprague-Dawley

KW - Recovery of Function

KW - Rotarod Performance Test

KW - Sensorimotor Cortex/pathology

KW - Spatial Behavior

KW - Time Factors

U2 - 10.33549/physiolres.932664

DO - 10.33549/physiolres.932664

M3 - SCORING: Journal article

C2 - 25194132

VL - 64

SP - 129

EP - 145

JO - PHYSIOL RES

JF - PHYSIOL RES

SN - 0862-8408

IS - 1

ER -