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Longitudinal monitoring of laboratory markers characterizes hospitalized and ambulatory COVID-19 patients

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Longitudinal monitoring of laboratory markers characterizes hospitalized and ambulatory COVID-19 patients. / Velavan, Thirumalaisamy P; Kuk, Salih; Linh, Le Thi Kieu; Lamsfus Calle, Carlos; Lalremruata, Albert; Pallerla, Srinivas Reddy; Kreidenweiss, Andrea; Held, Jana; Esen, Meral; Gabor, Julian; Neurohr, Eva Maria; Shamsrizi, Parichehr; Fathi, Anahita; Biecker, Erwin; Berg, Christoph P; Ramharter, Michael; Addo, Marylyn Martina; Kreuels, Benno; Kremsner, Peter G.

In: SCI REP-UK, Vol. 11, No. 1, 14471, 14.07.2021.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Velavan, TP, Kuk, S, Linh, LTK, Lamsfus Calle, C, Lalremruata, A, Pallerla, SR, Kreidenweiss, A, Held, J, Esen, M, Gabor, J, Neurohr, EM, Shamsrizi, P, Fathi, A, Biecker, E, Berg, CP, Ramharter, M, Addo, MM, Kreuels, B & Kremsner, PG 2021, 'Longitudinal monitoring of laboratory markers characterizes hospitalized and ambulatory COVID-19 patients', SCI REP-UK, vol. 11, no. 1, 14471. https://doi.org/10.1038/s41598-021-93950-x

APA

Velavan, T. P., Kuk, S., Linh, L. T. K., Lamsfus Calle, C., Lalremruata, A., Pallerla, S. R., Kreidenweiss, A., Held, J., Esen, M., Gabor, J., Neurohr, E. M., Shamsrizi, P., Fathi, A., Biecker, E., Berg, C. P., Ramharter, M., Addo, M. M., Kreuels, B., & Kremsner, P. G. (2021). Longitudinal monitoring of laboratory markers characterizes hospitalized and ambulatory COVID-19 patients. SCI REP-UK, 11(1), [14471]. https://doi.org/10.1038/s41598-021-93950-x

Vancouver

Velavan TP, Kuk S, Linh LTK, Lamsfus Calle C, Lalremruata A, Pallerla SR et al. Longitudinal monitoring of laboratory markers characterizes hospitalized and ambulatory COVID-19 patients. SCI REP-UK. 2021 Jul 14;11(1). 14471. https://doi.org/10.1038/s41598-021-93950-x

Bibtex

@article{9622dc2fe1e74fe192dc6d57d1c0aa3e,
title = "Longitudinal monitoring of laboratory markers characterizes hospitalized and ambulatory COVID-19 patients",
abstract = "Early detection of severe forms of COVID-19 is absolutely essential for timely triage of patients. We longitudinally followed-up two well-characterized patient groups, hospitalized moderate to severe (n = 26), and ambulatory mild COVID-19 patients (n = 16) at home quarantine. Human D-dimer, C-reactive protein (CRP), ferritin, cardiac troponin I, interleukin-6 (IL-6) levels were measured on day 1, day 7, day 14 and day 28. All hospitalized patients were SARS-CoV-2 positive on admission, while all ambulatory patients were SARS-CoV-2 positive at recruitment. Hospitalized patients had higher D-dimer, CRP and ferritin, cardiac troponin I and IL-6 levels than ambulatory patients (p < 0.001, p < 0.001, p = 0.016, p = 0.035, p = 0.002 respectively). Hospitalized patients experienced significant decreases in CRP, ferritin and IL-6 levels from admission to recovery (p < 0.001, p = 0.025, and p = 0.001 respectively). Cardiac troponin I levels were high during the acute phase in both hospitalized and ambulatory patients, indicating a potential myocardial injury. In summary, D-dimer, CRP, ferritin, cardiac troponin I, IL-6 are predictive laboratory markers and can largely determine the clinical course of COVID-19, in particular the prognosis of critically ill COVID-19 patients.",
keywords = "Ambulatory Care, Biomarkers/blood, C-Reactive Protein/analysis, COVID-19/blood, Early Diagnosis, Ferritins/blood, Fibrin Fibrinogen Degradation Products/analysis, Follow-Up Studies, Hospitalization, Humans, Interleukin-6/blood, Longitudinal Studies, Pneumonia, Viral/blood, Precision Medicine, Prognosis, Quarantine, SARS-CoV-2, Severity of Illness Index, Troponin I/blood",
author = "Velavan, {Thirumalaisamy P} and Salih Kuk and Linh, {Le Thi Kieu} and {Lamsfus Calle}, Carlos and Albert Lalremruata and Pallerla, {Srinivas Reddy} and Andrea Kreidenweiss and Jana Held and Meral Esen and Julian Gabor and Neurohr, {Eva Maria} and Parichehr Shamsrizi and Anahita Fathi and Erwin Biecker and Berg, {Christoph P} and Michael Ramharter and Addo, {Marylyn Martina} and Benno Kreuels and Kremsner, {Peter G}",
note = "{\textcopyright} 2021. The Author(s).",
year = "2021",
month = jul,
day = "14",
doi = "10.1038/s41598-021-93950-x",
language = "English",
volume = "11",
journal = "SCI REP-UK",
issn = "2045-2322",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - Longitudinal monitoring of laboratory markers characterizes hospitalized and ambulatory COVID-19 patients

AU - Velavan, Thirumalaisamy P

AU - Kuk, Salih

AU - Linh, Le Thi Kieu

AU - Lamsfus Calle, Carlos

AU - Lalremruata, Albert

AU - Pallerla, Srinivas Reddy

AU - Kreidenweiss, Andrea

AU - Held, Jana

AU - Esen, Meral

AU - Gabor, Julian

AU - Neurohr, Eva Maria

AU - Shamsrizi, Parichehr

AU - Fathi, Anahita

AU - Biecker, Erwin

AU - Berg, Christoph P

AU - Ramharter, Michael

AU - Addo, Marylyn Martina

AU - Kreuels, Benno

AU - Kremsner, Peter G

N1 - © 2021. The Author(s).

PY - 2021/7/14

Y1 - 2021/7/14

N2 - Early detection of severe forms of COVID-19 is absolutely essential for timely triage of patients. We longitudinally followed-up two well-characterized patient groups, hospitalized moderate to severe (n = 26), and ambulatory mild COVID-19 patients (n = 16) at home quarantine. Human D-dimer, C-reactive protein (CRP), ferritin, cardiac troponin I, interleukin-6 (IL-6) levels were measured on day 1, day 7, day 14 and day 28. All hospitalized patients were SARS-CoV-2 positive on admission, while all ambulatory patients were SARS-CoV-2 positive at recruitment. Hospitalized patients had higher D-dimer, CRP and ferritin, cardiac troponin I and IL-6 levels than ambulatory patients (p < 0.001, p < 0.001, p = 0.016, p = 0.035, p = 0.002 respectively). Hospitalized patients experienced significant decreases in CRP, ferritin and IL-6 levels from admission to recovery (p < 0.001, p = 0.025, and p = 0.001 respectively). Cardiac troponin I levels were high during the acute phase in both hospitalized and ambulatory patients, indicating a potential myocardial injury. In summary, D-dimer, CRP, ferritin, cardiac troponin I, IL-6 are predictive laboratory markers and can largely determine the clinical course of COVID-19, in particular the prognosis of critically ill COVID-19 patients.

AB - Early detection of severe forms of COVID-19 is absolutely essential for timely triage of patients. We longitudinally followed-up two well-characterized patient groups, hospitalized moderate to severe (n = 26), and ambulatory mild COVID-19 patients (n = 16) at home quarantine. Human D-dimer, C-reactive protein (CRP), ferritin, cardiac troponin I, interleukin-6 (IL-6) levels were measured on day 1, day 7, day 14 and day 28. All hospitalized patients were SARS-CoV-2 positive on admission, while all ambulatory patients were SARS-CoV-2 positive at recruitment. Hospitalized patients had higher D-dimer, CRP and ferritin, cardiac troponin I and IL-6 levels than ambulatory patients (p < 0.001, p < 0.001, p = 0.016, p = 0.035, p = 0.002 respectively). Hospitalized patients experienced significant decreases in CRP, ferritin and IL-6 levels from admission to recovery (p < 0.001, p = 0.025, and p = 0.001 respectively). Cardiac troponin I levels were high during the acute phase in both hospitalized and ambulatory patients, indicating a potential myocardial injury. In summary, D-dimer, CRP, ferritin, cardiac troponin I, IL-6 are predictive laboratory markers and can largely determine the clinical course of COVID-19, in particular the prognosis of critically ill COVID-19 patients.

KW - Ambulatory Care

KW - Biomarkers/blood

KW - C-Reactive Protein/analysis

KW - COVID-19/blood

KW - Early Diagnosis

KW - Ferritins/blood

KW - Fibrin Fibrinogen Degradation Products/analysis

KW - Follow-Up Studies

KW - Hospitalization

KW - Humans

KW - Interleukin-6/blood

KW - Longitudinal Studies

KW - Pneumonia, Viral/blood

KW - Precision Medicine

KW - Prognosis

KW - Quarantine

KW - SARS-CoV-2

KW - Severity of Illness Index

KW - Troponin I/blood

U2 - 10.1038/s41598-021-93950-x

DO - 10.1038/s41598-021-93950-x

M3 - SCORING: Journal article

C2 - 34262116

VL - 11

JO - SCI REP-UK

JF - SCI REP-UK

SN - 2045-2322

IS - 1

M1 - 14471

ER -