Localization of HCN1 channels to presynaptic compartments: novel plasticity that may contribute to hippocampal maturation.
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Localization of HCN1 channels to presynaptic compartments: novel plasticity that may contribute to hippocampal maturation. / Bender, Roland; Kirschstein, Timo; Kretz, Oliver; Brewster, Amy L; Richichi, Cristina; Rüschenschmidt, Christiane; Shigemoto, Ryuichi; Beck, Heinz; Frotscher, Michael; Baram, Tallie Z.
In: J NEUROSCI, Vol. 27, No. 17, 17, 2007, p. 4697-4706.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Localization of HCN1 channels to presynaptic compartments: novel plasticity that may contribute to hippocampal maturation.
AU - Bender, Roland
AU - Kirschstein, Timo
AU - Kretz, Oliver
AU - Brewster, Amy L
AU - Richichi, Cristina
AU - Rüschenschmidt, Christiane
AU - Shigemoto, Ryuichi
AU - Beck, Heinz
AU - Frotscher, Michael
AU - Baram, Tallie Z
PY - 2007
Y1 - 2007
N2 - Increasing evidence supports roles for the current mediated by hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, I(h), in hippocampal maturation and specifically in the evolving changes of intrinsic properties as well as network responses of hippocampal neurons. Here, we describe a novel developmental plasticity of HCN channel expression in axonal and presynaptic compartments: HCN1 channels were localized to axon terminals of the perforant path (the major hippocampal afferent pathway) of immature rats, where they modulated synaptic efficacy. However, presynaptic expression and functions of the channels disappeared with maturation. This was a result of altered channel transport to the axons, because HCN1 mRNA and protein levels in entorhinal cortex neurons, where the perforant path axons originate, were stable through adulthood. Blocking action potential firing in vitro increased presynaptic expression of HCN1 channels in the perforant path, suggesting that network activity contributed to regulating this expression. These findings support a novel developmentally regulated axonal transport of functional ion channels and suggest a role for HCN1 channel-mediated presynaptic I(h) in hippocampal maturation.
AB - Increasing evidence supports roles for the current mediated by hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, I(h), in hippocampal maturation and specifically in the evolving changes of intrinsic properties as well as network responses of hippocampal neurons. Here, we describe a novel developmental plasticity of HCN channel expression in axonal and presynaptic compartments: HCN1 channels were localized to axon terminals of the perforant path (the major hippocampal afferent pathway) of immature rats, where they modulated synaptic efficacy. However, presynaptic expression and functions of the channels disappeared with maturation. This was a result of altered channel transport to the axons, because HCN1 mRNA and protein levels in entorhinal cortex neurons, where the perforant path axons originate, were stable through adulthood. Blocking action potential firing in vitro increased presynaptic expression of HCN1 channels in the perforant path, suggesting that network activity contributed to regulating this expression. These findings support a novel developmentally regulated axonal transport of functional ion channels and suggest a role for HCN1 channel-mediated presynaptic I(h) in hippocampal maturation.
M3 - SCORING: Zeitschriftenaufsatz
VL - 27
SP - 4697
EP - 4706
JO - J NEUROSCI
JF - J NEUROSCI
SN - 0270-6474
IS - 17
M1 - 17
ER -
