Local Therapies Can Improve Intracerebral Control in Patients with Cerebral Metastasis from Gynecological Cancers
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Local Therapies Can Improve Intracerebral Control in Patients with Cerebral Metastasis from Gynecological Cancers. / Dziggel, Liesa; Janssen, Stefan; Bajrovic, Amira; Veninga, Theo; Trang, Ngo Thuy; Khoa, Mai Trong; Schild, Steven E; Rades, Dirk.
In: ANTICANCER RES, Vol. 36, No. 9, 09.2016, p. 4777-80.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Local Therapies Can Improve Intracerebral Control in Patients with Cerebral Metastasis from Gynecological Cancers
AU - Dziggel, Liesa
AU - Janssen, Stefan
AU - Bajrovic, Amira
AU - Veninga, Theo
AU - Trang, Ngo Thuy
AU - Khoa, Mai Trong
AU - Schild, Steven E
AU - Rades, Dirk
N1 - Copyright© 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.
PY - 2016/9
Y1 - 2016/9
N2 - BACKGROUND/AIM: Patients with gynecological malignancies account for 2% of patients with cerebral metastases. Many patients receive whole-brain irradiation (WBI) alone. Local therapies (resection, stereotactic radiosurgery (SRS)) are becoming more popular. This study compared intracerebral control after local therapy to WBI alone in patients with gynecological malignancies.PATIENTS AND METHODS: Of 56 patients, 45 received WBI alone, 6 SRS alone and 5 resection plus WBI. Treatment type, age, performance score, cancer site, number of cerebral lesions, metastases outside the brain, recursive partitioning analysis (RPA) class and period from gynecological cancer diagnosis to brain metastasis treatment were evaluated.RESULTS: On univariate analyses, local therapy (p=0.003), single cerebral lesion (p<0.001) and RPA class 1/2 (p=0.027) were positively related to intracerebral control. On Cox regression analysis, local therapy (p=0.013) and RPA class 1/2 (p=0.014) were significant.CONCLUSION: Local therapies led to better intracerebral control than WBI alone and should be considered for brain metastasis from gynecological malignancies whenever reasonable.
AB - BACKGROUND/AIM: Patients with gynecological malignancies account for 2% of patients with cerebral metastases. Many patients receive whole-brain irradiation (WBI) alone. Local therapies (resection, stereotactic radiosurgery (SRS)) are becoming more popular. This study compared intracerebral control after local therapy to WBI alone in patients with gynecological malignancies.PATIENTS AND METHODS: Of 56 patients, 45 received WBI alone, 6 SRS alone and 5 resection plus WBI. Treatment type, age, performance score, cancer site, number of cerebral lesions, metastases outside the brain, recursive partitioning analysis (RPA) class and period from gynecological cancer diagnosis to brain metastasis treatment were evaluated.RESULTS: On univariate analyses, local therapy (p=0.003), single cerebral lesion (p<0.001) and RPA class 1/2 (p=0.027) were positively related to intracerebral control. On Cox regression analysis, local therapy (p=0.013) and RPA class 1/2 (p=0.014) were significant.CONCLUSION: Local therapies led to better intracerebral control than WBI alone and should be considered for brain metastasis from gynecological malignancies whenever reasonable.
KW - Aged
KW - Brain
KW - Brain Neoplasms
KW - Cerebral Cortex
KW - Combined Modality Therapy
KW - Cranial Irradiation
KW - Female
KW - Genital Neoplasms, Female
KW - Humans
KW - Middle Aged
KW - Neoplasm Staging
KW - Proportional Hazards Models
KW - Radiosurgery
KW - Treatment Outcome
KW - Journal Article
U2 - 10.21873/anticanres.11035
DO - 10.21873/anticanres.11035
M3 - SCORING: Journal article
C2 - 27630327
VL - 36
SP - 4777
EP - 4780
JO - ANTICANCER RES
JF - ANTICANCER RES
SN - 0250-7005
IS - 9
ER -
