Living donor liver transplantation in adults in the MELD era in Germany--a multi-center retrospective analysis.
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Living donor liver transplantation in adults in the MELD era in Germany--a multi-center retrospective analysis. / Settmacher, Utz; Götz, Max; Rahmel, Axel; Bärthel, Erik; Schlitt, Hans; Puhl, Gero; Broering, Dieter; Lehner, Frank; Fischer, Lutz; Paul, Andreas; Schmidt, Jan; Nadalin, Silvio; Obed, Aiman; Heise, Michael.
In: TRANSPL INT, Vol. 24, No. 9, 9, 2011, p. 904-911.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Living donor liver transplantation in adults in the MELD era in Germany--a multi-center retrospective analysis.
AU - Settmacher, Utz
AU - Götz, Max
AU - Rahmel, Axel
AU - Bärthel, Erik
AU - Schlitt, Hans
AU - Puhl, Gero
AU - Broering, Dieter
AU - Lehner, Frank
AU - Fischer, Lutz
AU - Paul, Andreas
AU - Schmidt, Jan
AU - Nadalin, Silvio
AU - Obed, Aiman
AU - Heise, Michael
PY - 2011
Y1 - 2011
N2 - The aim of this analysis was to provide an update on the current trend in living donor liver transplantation (LDLT) for adult recipients in the model of end stage liver disease (MELD) era in Germany and to encourage a wider implementation of LDLT. We descriptively analysed the data of LDLTs in Germany from 15 December 2006 to 31 December 2009 using a multi-center retrospective analysis via a questionnaire and data provided by Eurotransplant. Ten German centers performed LDLTs in adults. Eighty four transplantations in 50 male recipients and 34 female recipients were performed during the review period, ranging from 1 to 16 LDLTs per center. Hepatocellular carcinoma in cirrhosis (15/84) was the most common transplantation indication. The recipient mean lab-MELD score was 15 (±8). Six re-transplantations were necessary after initial LDLTs. The 1-year patient survival was 81%. We obtained data of 79/84 donors. The incidence of complications was 30.4% (n?=?24). There were no grade 5 complications according to the Clavien classification. LDLT is an established treatment option that may reduce the waiting time, provides high quality split liver grafts and should be advocated in the MELD era to reduce organ shortage and 'death on the waiting list'.
AB - The aim of this analysis was to provide an update on the current trend in living donor liver transplantation (LDLT) for adult recipients in the model of end stage liver disease (MELD) era in Germany and to encourage a wider implementation of LDLT. We descriptively analysed the data of LDLTs in Germany from 15 December 2006 to 31 December 2009 using a multi-center retrospective analysis via a questionnaire and data provided by Eurotransplant. Ten German centers performed LDLTs in adults. Eighty four transplantations in 50 male recipients and 34 female recipients were performed during the review period, ranging from 1 to 16 LDLTs per center. Hepatocellular carcinoma in cirrhosis (15/84) was the most common transplantation indication. The recipient mean lab-MELD score was 15 (±8). Six re-transplantations were necessary after initial LDLTs. The 1-year patient survival was 81%. We obtained data of 79/84 donors. The incidence of complications was 30.4% (n?=?24). There were no grade 5 complications according to the Clavien classification. LDLT is an established treatment option that may reduce the waiting time, provides high quality split liver grafts and should be advocated in the MELD era to reduce organ shortage and 'death on the waiting list'.
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Middle Aged
KW - Retrospective Studies
KW - Carcinoma, Hepatocellular/surgery
KW - End Stage Liver Disease/surgery
KW - Liver Cirrhosis/surgery
KW - Liver Neoplasms/surgery
KW - Liver Transplantation/adverse effects/mortality/statistics & numerical data
KW - Living Donors/statistics & numerical data
KW - Waiting Lists/mortality
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Middle Aged
KW - Retrospective Studies
KW - Carcinoma, Hepatocellular/surgery
KW - End Stage Liver Disease/surgery
KW - Liver Cirrhosis/surgery
KW - Liver Neoplasms/surgery
KW - Liver Transplantation/adverse effects/mortality/statistics & numerical data
KW - Living Donors/statistics & numerical data
KW - Waiting Lists/mortality
M3 - SCORING: Journal article
VL - 24
SP - 904
EP - 911
JO - TRANSPL INT
JF - TRANSPL INT
SN - 0934-0874
IS - 9
M1 - 9
ER -
