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Liver transplantation for hepatocellular carcinoma in patients beyond the Milan but within the UCSF criteria

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Liver transplantation for hepatocellular carcinoma in patients beyond the Milan but within the UCSF criteria. / Sotiropoulos, Georgios C; Molmenti, E P; Omar, O S; Bockhorn, M; Brokalaki, E I; Lang, H; Frilling, A; Broelsch, C E; Malagó, M.

In: EUR J MED RES, Vol. 11, No. 11, 30.11.2006, p. 467-70.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Sotiropoulos, GC, Molmenti, EP, Omar, OS, Bockhorn, M, Brokalaki, EI, Lang, H, Frilling, A, Broelsch, CE & Malagó, M 2006, 'Liver transplantation for hepatocellular carcinoma in patients beyond the Milan but within the UCSF criteria', EUR J MED RES, vol. 11, no. 11, pp. 467-70.

APA

Sotiropoulos, G. C., Molmenti, E. P., Omar, O. S., Bockhorn, M., Brokalaki, E. I., Lang, H., Frilling, A., Broelsch, C. E., & Malagó, M. (2006). Liver transplantation for hepatocellular carcinoma in patients beyond the Milan but within the UCSF criteria. EUR J MED RES, 11(11), 467-70.

Vancouver

Sotiropoulos GC, Molmenti EP, Omar OS, Bockhorn M, Brokalaki EI, Lang H et al. Liver transplantation for hepatocellular carcinoma in patients beyond the Milan but within the UCSF criteria. EUR J MED RES. 2006 Nov 30;11(11):467-70.

Bibtex

@article{d651e6de6446407b86b3b8b677cb2559,
title = "Liver transplantation for hepatocellular carcinoma in patients beyond the Milan but within the UCSF criteria",
abstract = "AIM: Liver transplantation (LT) is the best therapy for early hepatocellular carcinoma (HCC) in cirrhosis. Whereas the Milan criteria are routinely applied, the University of California San Francisco (UCSF) criteria are occasionally considered in large-volume transplant centers. Poor information is available about the real {"}gain{"} in patients' outcome when extending the listing criteria from Milan to UCSF.PATIENTS AND METHODS: Out of 100 patients transplanted for HCC at our center, 4 patients exceeding the Milan but meeting the UCSF criteria were identified. Data of these patients were analysed for the purposes of this study.RESULTS: Three of them are currently alive after a median follow up of 57 months. One patient died 20 months post-transplant as a result of complications from hepatitis. Of the three who are alive, one underwent surgery for HCC recurrence 81 months post transplant. The remaining two have no evidence of tumor 56 and 57 months post transplant, respectively.CONCLUSION: Our results, as well as the reviewed literature, showed that only a small percentage of transplanted HCC patients can be classified as {"}beyond Milan-within UCSF{"}. These patients seem to have acceptable overall, as well as recurrence free survivals. Large-volume patients' series, intention- to-treat analysis based on the radiological findings and multi-center prospective studies are required, in order to further explore the outcome of patients {"}beyond Milan-within UCSF{"} criteria and in order to better define the risk/benefit ratio of a potential expansion of the current listing criteria.",
keywords = "Adult, Carcinoma, Hepatocellular, Humans, Italy, Liver Cirrhosis, Liver Neoplasms, Liver Transplantation, Middle Aged, Neoplasm Recurrence, Local, Practice Guidelines as Topic, Retrospective Studies, San Francisco, Survival Rate, Treatment Outcome",
author = "Sotiropoulos, {Georgios C} and Molmenti, {E P} and Omar, {O S} and M Bockhorn and Brokalaki, {E I} and H Lang and A Frilling and Broelsch, {C E} and M Malag{\'o}",
year = "2006",
month = nov,
day = "30",
language = "English",
volume = "11",
pages = "467--70",
journal = "EUR J MED RES",
issn = "0949-2321",
publisher = "BioMed Central Ltd.",
number = "11",

}

RIS

TY - JOUR

T1 - Liver transplantation for hepatocellular carcinoma in patients beyond the Milan but within the UCSF criteria

AU - Sotiropoulos, Georgios C

AU - Molmenti, E P

AU - Omar, O S

AU - Bockhorn, M

AU - Brokalaki, E I

AU - Lang, H

AU - Frilling, A

AU - Broelsch, C E

AU - Malagó, M

PY - 2006/11/30

Y1 - 2006/11/30

N2 - AIM: Liver transplantation (LT) is the best therapy for early hepatocellular carcinoma (HCC) in cirrhosis. Whereas the Milan criteria are routinely applied, the University of California San Francisco (UCSF) criteria are occasionally considered in large-volume transplant centers. Poor information is available about the real "gain" in patients' outcome when extending the listing criteria from Milan to UCSF.PATIENTS AND METHODS: Out of 100 patients transplanted for HCC at our center, 4 patients exceeding the Milan but meeting the UCSF criteria were identified. Data of these patients were analysed for the purposes of this study.RESULTS: Three of them are currently alive after a median follow up of 57 months. One patient died 20 months post-transplant as a result of complications from hepatitis. Of the three who are alive, one underwent surgery for HCC recurrence 81 months post transplant. The remaining two have no evidence of tumor 56 and 57 months post transplant, respectively.CONCLUSION: Our results, as well as the reviewed literature, showed that only a small percentage of transplanted HCC patients can be classified as "beyond Milan-within UCSF". These patients seem to have acceptable overall, as well as recurrence free survivals. Large-volume patients' series, intention- to-treat analysis based on the radiological findings and multi-center prospective studies are required, in order to further explore the outcome of patients "beyond Milan-within UCSF" criteria and in order to better define the risk/benefit ratio of a potential expansion of the current listing criteria.

AB - AIM: Liver transplantation (LT) is the best therapy for early hepatocellular carcinoma (HCC) in cirrhosis. Whereas the Milan criteria are routinely applied, the University of California San Francisco (UCSF) criteria are occasionally considered in large-volume transplant centers. Poor information is available about the real "gain" in patients' outcome when extending the listing criteria from Milan to UCSF.PATIENTS AND METHODS: Out of 100 patients transplanted for HCC at our center, 4 patients exceeding the Milan but meeting the UCSF criteria were identified. Data of these patients were analysed for the purposes of this study.RESULTS: Three of them are currently alive after a median follow up of 57 months. One patient died 20 months post-transplant as a result of complications from hepatitis. Of the three who are alive, one underwent surgery for HCC recurrence 81 months post transplant. The remaining two have no evidence of tumor 56 and 57 months post transplant, respectively.CONCLUSION: Our results, as well as the reviewed literature, showed that only a small percentage of transplanted HCC patients can be classified as "beyond Milan-within UCSF". These patients seem to have acceptable overall, as well as recurrence free survivals. Large-volume patients' series, intention- to-treat analysis based on the radiological findings and multi-center prospective studies are required, in order to further explore the outcome of patients "beyond Milan-within UCSF" criteria and in order to better define the risk/benefit ratio of a potential expansion of the current listing criteria.

KW - Adult

KW - Carcinoma, Hepatocellular

KW - Humans

KW - Italy

KW - Liver Cirrhosis

KW - Liver Neoplasms

KW - Liver Transplantation

KW - Middle Aged

KW - Neoplasm Recurrence, Local

KW - Practice Guidelines as Topic

KW - Retrospective Studies

KW - San Francisco

KW - Survival Rate

KW - Treatment Outcome

M3 - SCORING: Journal article

C2 - 17182358

VL - 11

SP - 467

EP - 470

JO - EUR J MED RES

JF - EUR J MED RES

SN - 0949-2321

IS - 11

ER -