Liver surgery-specific complications are an independent factor influencing long-term survival following major hepatectomy
Standard
Liver surgery-specific complications are an independent factor influencing long-term survival following major hepatectomy. / Kemper, Marius; Heumann, Asmus; Bibiza-Freiwald, Eric; Stüben, Björn-Ole; Izbicki, Jakob; Li, Jun.
In: HPB, Vol. 23, No. 10, 30.03.2021, p. 1496-1505.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Liver surgery-specific complications are an independent factor influencing long-term survival following major hepatectomy
AU - Kemper, Marius
AU - Heumann, Asmus
AU - Bibiza-Freiwald, Eric
AU - Stüben, Björn-Ole
AU - Izbicki, Jakob
AU - Li, Jun
PY - 2021/3/30
Y1 - 2021/3/30
N2 - BackgroundA severity grading system for liver surgery-specific complications, given the acronym FABIB, has been standardized to increase the feasibility and comparability of academic reports in liver surgery. Whether the FABIB score is associated with long-term survival following major hepatectomy has not been previously investigated.Methods297 consecutive patients who had undergone major hepatectomy between 2012 and 2019 were recruited. The postoperative complications were documented according to the FABIB system and, for comparison purposes, Clavien-Dindo classification. Their influence on 90-day mortality and long-term survival was analyzed retrospectively.ResultsTaking the relevant confounders into account, the FABIB score was a robust factor associated with long-term survival after major hepatectomy: patients with high FABIB scores (≥6) had a 2.415-fold higher risk of death compared to patients with low FABIB scores (≤2) (P = 0.002). In contrast to that, the Clavien-Dindo Classification (grade III + IV vs. grade I + II) was not associated with survival in our cohort (P = 0.873).ConclusionLiver surgery-specific complications, measured by the FABIB system, impact long-term survival after major hepatectomy independent of relevant confounders. We propose the FABIB score as a composite endpoint for randomized controlled trials and a quality assessment tool in liver surgery.
AB - BackgroundA severity grading system for liver surgery-specific complications, given the acronym FABIB, has been standardized to increase the feasibility and comparability of academic reports in liver surgery. Whether the FABIB score is associated with long-term survival following major hepatectomy has not been previously investigated.Methods297 consecutive patients who had undergone major hepatectomy between 2012 and 2019 were recruited. The postoperative complications were documented according to the FABIB system and, for comparison purposes, Clavien-Dindo classification. Their influence on 90-day mortality and long-term survival was analyzed retrospectively.ResultsTaking the relevant confounders into account, the FABIB score was a robust factor associated with long-term survival after major hepatectomy: patients with high FABIB scores (≥6) had a 2.415-fold higher risk of death compared to patients with low FABIB scores (≤2) (P = 0.002). In contrast to that, the Clavien-Dindo Classification (grade III + IV vs. grade I + II) was not associated with survival in our cohort (P = 0.873).ConclusionLiver surgery-specific complications, measured by the FABIB system, impact long-term survival after major hepatectomy independent of relevant confounders. We propose the FABIB score as a composite endpoint for randomized controlled trials and a quality assessment tool in liver surgery.
U2 - https://doi.org/10.1016/j.hpb.2021.02.013
DO - https://doi.org/10.1016/j.hpb.2021.02.013
M3 - SCORING: Journal article
VL - 23
SP - 1496
EP - 1505
JO - HPB
JF - HPB
SN - 1365-182X
IS - 10
ER -
