Livedoid vasculopathy - A diagnostic and therapeutic challenge
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Livedoid vasculopathy - A diagnostic and therapeutic challenge. / Burg, Maria Rosa; Mitschang, Carolin; Goerge, Tobias; Schneider, Stefan Werner.
In: FRONT MED-LAUSANNE, Vol. 9, 1012178, 03.10.2022.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - Livedoid vasculopathy - A diagnostic and therapeutic challenge
AU - Burg, Maria Rosa
AU - Mitschang, Carolin
AU - Goerge, Tobias
AU - Schneider, Stefan Werner
N1 - Copyright © 2022 Burg, Mitschang, Goerge and Schneider.
PY - 2022/10/3
Y1 - 2022/10/3
N2 - Livedoid vasculopathy is a rare, chronic-recurrent occlusive disorder in the microcirculation of dermal vessels. The clinical appearance is characterized by Livedo racemosa, painful ulceration, located in the distal parts of the lower extremities, followed by healing as porcelain-white, atrophic scars, the so-called Atrophie blanche. Different conditions that can promote a hypercoagulable state, such as inherited and acquired thrombophilias, autoimmune connective-tissue diseases and neoplasms, can be associated with livedoid vasculopathy. Therefore, livedoid vasculopathy is currently considered to be a coagulation disorder, clearly distinguished from inflammatory vasculitis. Although there are hints to hypercoaguability and secondary inflammation, pathophysiology is not completely understood. Diagnosis is made by synopsis of history, clinical and histopathological findings. Early and adequate therapy is essential to maintain life quality and avoid irreversible complications. Better understanding of molecular mechanisms is required to establish appropriate therapy regimens. This article presents the current state of knowledge about livedoid vasculopathy and proposes an algorithmic approach for diagnosis and therapy.
AB - Livedoid vasculopathy is a rare, chronic-recurrent occlusive disorder in the microcirculation of dermal vessels. The clinical appearance is characterized by Livedo racemosa, painful ulceration, located in the distal parts of the lower extremities, followed by healing as porcelain-white, atrophic scars, the so-called Atrophie blanche. Different conditions that can promote a hypercoagulable state, such as inherited and acquired thrombophilias, autoimmune connective-tissue diseases and neoplasms, can be associated with livedoid vasculopathy. Therefore, livedoid vasculopathy is currently considered to be a coagulation disorder, clearly distinguished from inflammatory vasculitis. Although there are hints to hypercoaguability and secondary inflammation, pathophysiology is not completely understood. Diagnosis is made by synopsis of history, clinical and histopathological findings. Early and adequate therapy is essential to maintain life quality and avoid irreversible complications. Better understanding of molecular mechanisms is required to establish appropriate therapy regimens. This article presents the current state of knowledge about livedoid vasculopathy and proposes an algorithmic approach for diagnosis and therapy.
U2 - 10.3389/fmed.2022.1012178
DO - 10.3389/fmed.2022.1012178
M3 - SCORING: Review article
C2 - 36262273
VL - 9
JO - FRONT MED-LAUSANNE
JF - FRONT MED-LAUSANNE
SN - 2296-858X
M1 - 1012178
ER -
