Liquid biopsy: blood-based analyses of circulating cell-free DNA in xenografts
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Liquid biopsy: blood-based analyses of circulating cell-free DNA in xenografts. / Heidrich, Isabel; Pantel, Klaus.
In: EMBO MOL MED, Vol. 14, No. 8, e16326, 08.08.2022.Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research
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TY - JOUR
T1 - Liquid biopsy: blood-based analyses of circulating cell-free DNA in xenografts
AU - Heidrich, Isabel
AU - Pantel, Klaus
N1 - © 2022 The Authors. Published under the terms of the CC BY 4.0 license.
PY - 2022/8/8
Y1 - 2022/8/8
N2 - The liquid biopsy concept has been introduced for circulating tumor cells more than 10 years ago (Pantel & Alix-Panabieres, 2010) and rapidly extended to cell-free DNA released from tumor cells (ctDNA; Lo et al, 2021) and other tumor-derived products such as circulating cell-free RNA (noncoding and messenger RNA), extracellular vesicles, or tumor-educated platelets (Alix-Panabières & Pantel, 2021). In this issue of EMBO Molecular Medicine, the report of Sauer et al (2022) demonstrates the feasibility of longitudinal monitoring of disease burden and response using ctDNA from dried blood spots in xenograft models.
AB - The liquid biopsy concept has been introduced for circulating tumor cells more than 10 years ago (Pantel & Alix-Panabieres, 2010) and rapidly extended to cell-free DNA released from tumor cells (ctDNA; Lo et al, 2021) and other tumor-derived products such as circulating cell-free RNA (noncoding and messenger RNA), extracellular vesicles, or tumor-educated platelets (Alix-Panabières & Pantel, 2021). In this issue of EMBO Molecular Medicine, the report of Sauer et al (2022) demonstrates the feasibility of longitudinal monitoring of disease burden and response using ctDNA from dried blood spots in xenograft models.
KW - Animals
KW - Biomarkers, Tumor
KW - Cell-Free Nucleic Acids
KW - Circulating Tumor DNA/genetics
KW - Heterografts
KW - Humans
KW - Liquid Biopsy
KW - Neoplastic Cells, Circulating
U2 - 10.15252/emmm.202216326
DO - 10.15252/emmm.202216326
M3 - Other (editorial matter etc.)
C2 - 35903952
VL - 14
JO - EMBO MOL MED
JF - EMBO MOL MED
SN - 1757-4676
IS - 8
M1 - e16326
ER -