Linking NAADP to ion channel activity: a unifying hypothesis.
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Linking NAADP to ion channel activity: a unifying hypothesis. / Guse, Andreas H.; Andreas, H.
In: SCI SIGNAL, Vol. 5, No. 221, 221, 2012, p. 18.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Linking NAADP to ion channel activity: a unifying hypothesis.
AU - Guse, Andreas H.
AU - Andreas, H
PY - 2012
Y1 - 2012
N2 - Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent Ca(2+)-releasing second messenger that might regulate different ion channels, including the ryanodine receptor, two-pore channels, and TRP-ML1 (transient receptor potential channel, subtype mucolipin 1), a Ca(2+) channel localized to lysosomes. New evidence suggests that a 22- and 23-kilodalton pair of proteins could be the receptor for NAADP. Labeling of NAADP binding proteins was independent of overexpression or knockout of two-pore channels, indicating that two-pore channels, although regulated by NAADP, are not the NAADP receptors. I propose that NAADP binding proteins could bind to different ion channels and thus may explain how NAADP regulates diverse ion channels.
AB - Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent Ca(2+)-releasing second messenger that might regulate different ion channels, including the ryanodine receptor, two-pore channels, and TRP-ML1 (transient receptor potential channel, subtype mucolipin 1), a Ca(2+) channel localized to lysosomes. New evidence suggests that a 22- and 23-kilodalton pair of proteins could be the receptor for NAADP. Labeling of NAADP binding proteins was independent of overexpression or knockout of two-pore channels, indicating that two-pore channels, although regulated by NAADP, are not the NAADP receptors. I propose that NAADP binding proteins could bind to different ion channels and thus may explain how NAADP regulates diverse ion channels.
KW - Animals
KW - Humans
KW - Gene Knockdown Techniques
KW - Calcium/metabolism
KW - Lysosomes/genetics/metabolism
KW - NADP/analogs & derivatives/genetics/metabolism
KW - Second Messenger Systems/physiology
KW - Transient Receptor Potential Channels/genetics/metabolism
KW - Animals
KW - Humans
KW - Gene Knockdown Techniques
KW - Calcium/metabolism
KW - Lysosomes/genetics/metabolism
KW - NADP/analogs & derivatives/genetics/metabolism
KW - Second Messenger Systems/physiology
KW - Transient Receptor Potential Channels/genetics/metabolism
M3 - SCORING: Journal article
VL - 5
SP - 18
JO - SCI SIGNAL
JF - SCI SIGNAL
SN - 1945-0877
IS - 221
M1 - 221
ER -
