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Limits of and Complications after Embolization of the Hepatic Artery and Portal Vein to Induce Segmental Hypertrophy of the Liver: A Large Mini-Pig Study

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Limits of and Complications after Embolization of the Hepatic Artery and Portal Vein to Induce Segmental Hypertrophy of the Liver: A Large Mini-Pig Study. / Heits, Nils; Mueller, Lars; Koops, Andreas; Koops, Susan; Herrmann, Jochen; Hendricks, Alexander; Kabar, Iyad; Arlt, Alexander; Braun, Felix; Becker, Thomas; Wilms, Christian.

In: EUR SURG RES, Vol. 57, No. 3-4, 2016, p. 155-170.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Heits, N, Mueller, L, Koops, A, Koops, S, Herrmann, J, Hendricks, A, Kabar, I, Arlt, A, Braun, F, Becker, T & Wilms, C 2016, 'Limits of and Complications after Embolization of the Hepatic Artery and Portal Vein to Induce Segmental Hypertrophy of the Liver: A Large Mini-Pig Study', EUR SURG RES, vol. 57, no. 3-4, pp. 155-170. https://doi.org/10.1159/000447511

APA

Heits, N., Mueller, L., Koops, A., Koops, S., Herrmann, J., Hendricks, A., Kabar, I., Arlt, A., Braun, F., Becker, T., & Wilms, C. (2016). Limits of and Complications after Embolization of the Hepatic Artery and Portal Vein to Induce Segmental Hypertrophy of the Liver: A Large Mini-Pig Study. EUR SURG RES, 57(3-4), 155-170. https://doi.org/10.1159/000447511

Vancouver

Heits N, Mueller L, Koops A, Koops S, Herrmann J, Hendricks A et al. Limits of and Complications after Embolization of the Hepatic Artery and Portal Vein to Induce Segmental Hypertrophy of the Liver: A Large Mini-Pig Study. EUR SURG RES. 2016;57(3-4):155-170. https://doi.org/10.1159/000447511

Bibtex

@article{b084eaaff3a64ad28e77702664c23331,
title = "Limits of and Complications after Embolization of the Hepatic Artery and Portal Vein to Induce Segmental Hypertrophy of the Liver: A Large Mini-Pig Study",
abstract = "BACKGROUND: The aim of this study was to compare arterial embolization (AE) with portal vein embolization (PVE) for the induction of segmental hypertrophy regarding procedural efficacy, safety and outcome.METHODS: A total of 29 mini pigs were subjected to PVE, AE or assigned to the sham (SO) group. Correspondingly, 75% of the hepatic artery or portal vein branches were embolized. Growth and atrophy of the liver lobes, calculating the liver-to-body weight index (LBWI), laboratory data, arteriography, portography, Doppler ultrasound (US) and histopathology were analyzed.RESULTS: After PVE, 2 animals had to be excluded due to technical problems. After AE, 4 animals had to be excluded because of technical problems and early sacrifice. Postprocedural US demonstrated effective AE and PVE of the respective lobes. Four weeks after PVE, portography showed a slow refilling of the embolized lobe by collateral portal venous vessels. Four weeks after AE, arteriography revealed a slight revascularization of the embolized lobes by arterial neovascularization. Segmental AE led to extensive necrotic and inflammatory alterations in the liver and bile duct parenchyma. Significant hypertrophy of the non-embolized lobe was only noted in the PVE group (LBWI: 0.91 ± 0.28%; p = 0.001). There was no increase in the non-embolized lobe in the AE (LBWI: 0.45 ± 0.087%) and SO group (LBWI: 0.45 ± 0.13%).CONCLUSION: PVE is safe and effective to induce segmental hypertrophy. Portal reperfusion by collateral vessels may limit hypertrophy. AE did not increase the segmental hepatic volume but carries the risk of extensive necrotic inflammatory damage.",
keywords = "Journal Article",
author = "Nils Heits and Lars Mueller and Andreas Koops and Susan Koops and Jochen Herrmann and Alexander Hendricks and Iyad Kabar and Alexander Arlt and Felix Braun and Thomas Becker and Christian Wilms",
note = "{\textcopyright} 2016 S. Karger AG, Basel.",
year = "2016",
doi = "10.1159/000447511",
language = "English",
volume = "57",
pages = "155--170",
journal = "EUR SURG RES",
issn = "0014-312X",
publisher = "S. Karger AG",
number = "3-4",

}

RIS

TY - JOUR

T1 - Limits of and Complications after Embolization of the Hepatic Artery and Portal Vein to Induce Segmental Hypertrophy of the Liver: A Large Mini-Pig Study

AU - Heits, Nils

AU - Mueller, Lars

AU - Koops, Andreas

AU - Koops, Susan

AU - Herrmann, Jochen

AU - Hendricks, Alexander

AU - Kabar, Iyad

AU - Arlt, Alexander

AU - Braun, Felix

AU - Becker, Thomas

AU - Wilms, Christian

N1 - © 2016 S. Karger AG, Basel.

PY - 2016

Y1 - 2016

N2 - BACKGROUND: The aim of this study was to compare arterial embolization (AE) with portal vein embolization (PVE) for the induction of segmental hypertrophy regarding procedural efficacy, safety and outcome.METHODS: A total of 29 mini pigs were subjected to PVE, AE or assigned to the sham (SO) group. Correspondingly, 75% of the hepatic artery or portal vein branches were embolized. Growth and atrophy of the liver lobes, calculating the liver-to-body weight index (LBWI), laboratory data, arteriography, portography, Doppler ultrasound (US) and histopathology were analyzed.RESULTS: After PVE, 2 animals had to be excluded due to technical problems. After AE, 4 animals had to be excluded because of technical problems and early sacrifice. Postprocedural US demonstrated effective AE and PVE of the respective lobes. Four weeks after PVE, portography showed a slow refilling of the embolized lobe by collateral portal venous vessels. Four weeks after AE, arteriography revealed a slight revascularization of the embolized lobes by arterial neovascularization. Segmental AE led to extensive necrotic and inflammatory alterations in the liver and bile duct parenchyma. Significant hypertrophy of the non-embolized lobe was only noted in the PVE group (LBWI: 0.91 ± 0.28%; p = 0.001). There was no increase in the non-embolized lobe in the AE (LBWI: 0.45 ± 0.087%) and SO group (LBWI: 0.45 ± 0.13%).CONCLUSION: PVE is safe and effective to induce segmental hypertrophy. Portal reperfusion by collateral vessels may limit hypertrophy. AE did not increase the segmental hepatic volume but carries the risk of extensive necrotic inflammatory damage.

AB - BACKGROUND: The aim of this study was to compare arterial embolization (AE) with portal vein embolization (PVE) for the induction of segmental hypertrophy regarding procedural efficacy, safety and outcome.METHODS: A total of 29 mini pigs were subjected to PVE, AE or assigned to the sham (SO) group. Correspondingly, 75% of the hepatic artery or portal vein branches were embolized. Growth and atrophy of the liver lobes, calculating the liver-to-body weight index (LBWI), laboratory data, arteriography, portography, Doppler ultrasound (US) and histopathology were analyzed.RESULTS: After PVE, 2 animals had to be excluded due to technical problems. After AE, 4 animals had to be excluded because of technical problems and early sacrifice. Postprocedural US demonstrated effective AE and PVE of the respective lobes. Four weeks after PVE, portography showed a slow refilling of the embolized lobe by collateral portal venous vessels. Four weeks after AE, arteriography revealed a slight revascularization of the embolized lobes by arterial neovascularization. Segmental AE led to extensive necrotic and inflammatory alterations in the liver and bile duct parenchyma. Significant hypertrophy of the non-embolized lobe was only noted in the PVE group (LBWI: 0.91 ± 0.28%; p = 0.001). There was no increase in the non-embolized lobe in the AE (LBWI: 0.45 ± 0.087%) and SO group (LBWI: 0.45 ± 0.13%).CONCLUSION: PVE is safe and effective to induce segmental hypertrophy. Portal reperfusion by collateral vessels may limit hypertrophy. AE did not increase the segmental hepatic volume but carries the risk of extensive necrotic inflammatory damage.

KW - Journal Article

U2 - 10.1159/000447511

DO - 10.1159/000447511

M3 - SCORING: Journal article

C2 - 27434375

VL - 57

SP - 155

EP - 170

JO - EUR SURG RES

JF - EUR SURG RES

SN - 0014-312X

IS - 3-4

ER -