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Limited Prognostic Value of Tumor Necrosis in Patients With Renal Cell Carcinoma.

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Limited Prognostic Value of Tumor Necrosis in Patients With Renal Cell Carcinoma. / Isbarn, Hendrik; Patard, Jean-Jacques; Lughezzani, Gi Ovanni; Rioux-Leclercq, Nathalie; Crépel, Maxime; Cindolo, Luca; de La Taille, Alexandre; Zini, Laurent; Villers, Arnauld; Shariat, Shahrokh F; Bertini, Roberto; Karakiewicz, Pierre I.

In: UROLOGY, 2009.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Isbarn, H, Patard, J-J, Lughezzani, GO, Rioux-Leclercq, N, Crépel, M, Cindolo, L, de La Taille, A, Zini, L, Villers, A, Shariat, SF, Bertini, R & Karakiewicz, PI 2009, 'Limited Prognostic Value of Tumor Necrosis in Patients With Renal Cell Carcinoma.', UROLOGY. <http://www.ncbi.nlm.nih.gov/pubmed/19781745?dopt=Citation>

APA

Isbarn, H., Patard, J-J., Lughezzani, G. O., Rioux-Leclercq, N., Crépel, M., Cindolo, L., de La Taille, A., Zini, L., Villers, A., Shariat, S. F., Bertini, R., & Karakiewicz, P. I. (2009). Limited Prognostic Value of Tumor Necrosis in Patients With Renal Cell Carcinoma. UROLOGY. http://www.ncbi.nlm.nih.gov/pubmed/19781745?dopt=Citation

Vancouver

Isbarn H, Patard J-J, Lughezzani GO, Rioux-Leclercq N, Crépel M, Cindolo L et al. Limited Prognostic Value of Tumor Necrosis in Patients With Renal Cell Carcinoma. UROLOGY. 2009.

Bibtex

@article{37dc0d2a84c94cb780aaa32ba136e031,
title = "Limited Prognostic Value of Tumor Necrosis in Patients With Renal Cell Carcinoma.",
abstract = "OBJECTIVES: To test whether tumor necrosis (TN) could improve the prognostic ability of the predictors of 2 established prognostic renal cell carcinoma (RCC) models. Presence of TN within the nephrectomy specimen is considered an important prognostic marker in patients with RCC. However, its added prognostic value along with established cancer-specific mortality (CSM) predictors has never been formally tested. METHODS: We retrospectively analyzed data of 1526 patients with all stages of RCC, who were treated with radical or partial nephrectomy at 6 institutions between 1988 and 2004. Univariate and multivariate Cox-regression models tested the statistical significance of TN in CSM predictions. Covariates consisted of TNM stage, Fuhrman grade, tumor size, and symptom classification. The analyses first addressed the entire patient population (n = 1526) and then repeated in patients with exclusive clear-cell histology (n = 1320). RESULTS: TN was present in 476 patients (31.2%). TN was a statistically significant predictor of CSM (hazard ratio: 2.73; P",
author = "Hendrik Isbarn and Jean-Jacques Patard and Lughezzani, {Gi Ovanni} and Nathalie Rioux-Leclercq and Maxime Cr{\'e}pel and Luca Cindolo and {de La Taille}, Alexandre and Laurent Zini and Arnauld Villers and Shariat, {Shahrokh F} and Roberto Bertini and Karakiewicz, {Pierre I}",
year = "2009",
language = "Deutsch",
journal = "UROLOGY",
issn = "0090-4295",
publisher = "Elsevier Inc.",

}

RIS

TY - JOUR

T1 - Limited Prognostic Value of Tumor Necrosis in Patients With Renal Cell Carcinoma.

AU - Isbarn, Hendrik

AU - Patard, Jean-Jacques

AU - Lughezzani, Gi Ovanni

AU - Rioux-Leclercq, Nathalie

AU - Crépel, Maxime

AU - Cindolo, Luca

AU - de La Taille, Alexandre

AU - Zini, Laurent

AU - Villers, Arnauld

AU - Shariat, Shahrokh F

AU - Bertini, Roberto

AU - Karakiewicz, Pierre I

PY - 2009

Y1 - 2009

N2 - OBJECTIVES: To test whether tumor necrosis (TN) could improve the prognostic ability of the predictors of 2 established prognostic renal cell carcinoma (RCC) models. Presence of TN within the nephrectomy specimen is considered an important prognostic marker in patients with RCC. However, its added prognostic value along with established cancer-specific mortality (CSM) predictors has never been formally tested. METHODS: We retrospectively analyzed data of 1526 patients with all stages of RCC, who were treated with radical or partial nephrectomy at 6 institutions between 1988 and 2004. Univariate and multivariate Cox-regression models tested the statistical significance of TN in CSM predictions. Covariates consisted of TNM stage, Fuhrman grade, tumor size, and symptom classification. The analyses first addressed the entire patient population (n = 1526) and then repeated in patients with exclusive clear-cell histology (n = 1320). RESULTS: TN was present in 476 patients (31.2%). TN was a statistically significant predictor of CSM (hazard ratio: 2.73; P

AB - OBJECTIVES: To test whether tumor necrosis (TN) could improve the prognostic ability of the predictors of 2 established prognostic renal cell carcinoma (RCC) models. Presence of TN within the nephrectomy specimen is considered an important prognostic marker in patients with RCC. However, its added prognostic value along with established cancer-specific mortality (CSM) predictors has never been formally tested. METHODS: We retrospectively analyzed data of 1526 patients with all stages of RCC, who were treated with radical or partial nephrectomy at 6 institutions between 1988 and 2004. Univariate and multivariate Cox-regression models tested the statistical significance of TN in CSM predictions. Covariates consisted of TNM stage, Fuhrman grade, tumor size, and symptom classification. The analyses first addressed the entire patient population (n = 1526) and then repeated in patients with exclusive clear-cell histology (n = 1320). RESULTS: TN was present in 476 patients (31.2%). TN was a statistically significant predictor of CSM (hazard ratio: 2.73; P

M3 - SCORING: Zeitschriftenaufsatz

JO - UROLOGY

JF - UROLOGY

SN - 0090-4295

ER -