Limitations of Elastography Based Prostate Biopsy

Jonas Schiffmann; Mircea Grindei; Zhe Tian; Dany-Jan Yassin; Tobias Steinwender; Sami-Ramzi Leyh-Bannurah; Marco Randazzo; Maciej Kwiatkowski; Pierre I Karakiewicz; Peter Hammerer; Lukas Manka

doi:10.1016/j.juro.2015.12.086

Limitations of Elastography Based Prostate Biopsy

Standard

Limitations of Elastography Based Prostate Biopsy. / Schiffmann, Jonas; Grindei, Mircea; Tian, Zhe; Yassin, Dany-Jan; Steinwender, Tobias; Leyh-Bannurah, Sami-Ramzi; Randazzo, Marco; Kwiatkowski, Maciej; Karakiewicz, Pierre I; Hammerer, Peter; Manka, Lukas.

In: J UROLOGY, Vol. 195, No. 6, 06.2016, p. 1731-6.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Schiffmann, J, Grindei, M, Tian, Z, Yassin, D-J, Steinwender, T, Leyh-Bannurah, S-R, Randazzo, M, Kwiatkowski, M, Karakiewicz, PI, Hammerer, P & Manka, L 2016, 'Limitations of Elastography Based Prostate Biopsy', J UROLOGY, vol. 195, no. 6, pp. 1731-6. https://doi.org/10.1016/j.juro.2015.12.086

APA

Schiffmann, J., Grindei, M., Tian, Z., Yassin, D-J., Steinwender, T., Leyh-Bannurah, S-R., Randazzo, M., Kwiatkowski, M., Karakiewicz, P. I., Hammerer, P., & Manka, L. (2016). Limitations of Elastography Based Prostate Biopsy. J UROLOGY, 195(6), 1731-6. https://doi.org/10.1016/j.juro.2015.12.086

Vancouver

Schiffmann J, Grindei M, Tian Z, Yassin D-J, Steinwender T, Leyh-Bannurah S-R et al. Limitations of Elastography Based Prostate Biopsy. J UROLOGY. 2016 Jun;195(6):1731-6. https://doi.org/10.1016/j.juro.2015.12.086

Bibtex

@article{5a40686097c24ee79b1e46f787c8399b,

title = "Limitations of Elastography Based Prostate Biopsy",

abstract = "PURPOSE: The role of elastography in patients initially and at repeat prostate biopsy is still indeterminate. The existing literature is sparse and controversial.MATERIALS AND METHODS: We studied patients who underwent elastography based and systematic biopsy between October 2009 and February 2015 at Braunschweig Prostate Cancer Center. Patients were separated according to first vs repeat biopsy setting. Each prostate sextant was considered an individual case. The sensitivity, specificity, positive and negative predictive values, and accuracy of elastography to predict biopsy results were analyzed. The 95% CIs were determined by bootstrapping analysis of 2,000 samples.RESULTS: Overall 679 men and a total of 4,074 sextants were identified. Of the 679 men 160 (23.6%) underwent first biopsy and 519 (76.4%) underwent repeat biopsy. In the 160 men at first biopsy sensitivity was 18.0% (95% CI 14.5-21.3), specificity was 87.7% (95% CI 85.3-89.9), positive predictive value was 36.6% (95% CI 28.4-45.4), negative predictive value was 73.0% (95% CI 67.5-77.9) and accuracy was 67.9% (95% CI 63.4-72.2). Results in 519 men (76.4%) at repeat biopsy were 19.8% (95% CI 16.0-23.7), 90.9% (95% CI 89.9-91.9), 20.1% (95% CI 15.8-24.8), 90.7% (95% CI 89.0-92.3) and 83.5% (95% CI 81.6-85.2), respectively.CONCLUSIONS: We found limited reliability of elastography prediction at prostate biopsy in patients at first and repeat biopsies. Based on our analyses we cannot recommend a variation of well established systematic biopsy patterns or a decrease in biopsy cores based on elastography.",

keywords = "Aged, Biopsy, Elasticity Imaging Techniques, Humans, Male, Middle Aged, Predictive Value of Tests, Prostate, Prostatic Neoplasms, Reproducibility of Results, Sensitivity and Specificity, Journal Article",

author = "Jonas Schiffmann and Mircea Grindei and Zhe Tian and Dany-Jan Yassin and Tobias Steinwender and Sami-Ramzi Leyh-Bannurah and Marco Randazzo and Maciej Kwiatkowski and Karakiewicz, {Pierre I} and Peter Hammerer and Lukas Manka",

year = "2016",

month = jun,

doi = "10.1016/j.juro.2015.12.086",

language = "English",

volume = "195",

pages = "1731--6",

journal = "J UROLOGY",

issn = "0022-5347",

publisher = "Elsevier Inc.",

number = "6",

}

RIS

TY - JOUR

T1 - Limitations of Elastography Based Prostate Biopsy

AU - Schiffmann, Jonas

AU - Grindei, Mircea

AU - Tian, Zhe

AU - Yassin, Dany-Jan

AU - Steinwender, Tobias

AU - Leyh-Bannurah, Sami-Ramzi

AU - Randazzo, Marco

AU - Kwiatkowski, Maciej

AU - Karakiewicz, Pierre I

AU - Hammerer, Peter

AU - Manka, Lukas

PY - 2016/6

Y1 - 2016/6

N2 - PURPOSE: The role of elastography in patients initially and at repeat prostate biopsy is still indeterminate. The existing literature is sparse and controversial.MATERIALS AND METHODS: We studied patients who underwent elastography based and systematic biopsy between October 2009 and February 2015 at Braunschweig Prostate Cancer Center. Patients were separated according to first vs repeat biopsy setting. Each prostate sextant was considered an individual case. The sensitivity, specificity, positive and negative predictive values, and accuracy of elastography to predict biopsy results were analyzed. The 95% CIs were determined by bootstrapping analysis of 2,000 samples.RESULTS: Overall 679 men and a total of 4,074 sextants were identified. Of the 679 men 160 (23.6%) underwent first biopsy and 519 (76.4%) underwent repeat biopsy. In the 160 men at first biopsy sensitivity was 18.0% (95% CI 14.5-21.3), specificity was 87.7% (95% CI 85.3-89.9), positive predictive value was 36.6% (95% CI 28.4-45.4), negative predictive value was 73.0% (95% CI 67.5-77.9) and accuracy was 67.9% (95% CI 63.4-72.2). Results in 519 men (76.4%) at repeat biopsy were 19.8% (95% CI 16.0-23.7), 90.9% (95% CI 89.9-91.9), 20.1% (95% CI 15.8-24.8), 90.7% (95% CI 89.0-92.3) and 83.5% (95% CI 81.6-85.2), respectively.CONCLUSIONS: We found limited reliability of elastography prediction at prostate biopsy in patients at first and repeat biopsies. Based on our analyses we cannot recommend a variation of well established systematic biopsy patterns or a decrease in biopsy cores based on elastography.

AB - PURPOSE: The role of elastography in patients initially and at repeat prostate biopsy is still indeterminate. The existing literature is sparse and controversial.MATERIALS AND METHODS: We studied patients who underwent elastography based and systematic biopsy between October 2009 and February 2015 at Braunschweig Prostate Cancer Center. Patients were separated according to first vs repeat biopsy setting. Each prostate sextant was considered an individual case. The sensitivity, specificity, positive and negative predictive values, and accuracy of elastography to predict biopsy results were analyzed. The 95% CIs were determined by bootstrapping analysis of 2,000 samples.RESULTS: Overall 679 men and a total of 4,074 sextants were identified. Of the 679 men 160 (23.6%) underwent first biopsy and 519 (76.4%) underwent repeat biopsy. In the 160 men at first biopsy sensitivity was 18.0% (95% CI 14.5-21.3), specificity was 87.7% (95% CI 85.3-89.9), positive predictive value was 36.6% (95% CI 28.4-45.4), negative predictive value was 73.0% (95% CI 67.5-77.9) and accuracy was 67.9% (95% CI 63.4-72.2). Results in 519 men (76.4%) at repeat biopsy were 19.8% (95% CI 16.0-23.7), 90.9% (95% CI 89.9-91.9), 20.1% (95% CI 15.8-24.8), 90.7% (95% CI 89.0-92.3) and 83.5% (95% CI 81.6-85.2), respectively.CONCLUSIONS: We found limited reliability of elastography prediction at prostate biopsy in patients at first and repeat biopsies. Based on our analyses we cannot recommend a variation of well established systematic biopsy patterns or a decrease in biopsy cores based on elastography.

KW - Aged

KW - Biopsy

KW - Elasticity Imaging Techniques

KW - Humans

KW - Male

KW - Middle Aged

KW - Predictive Value of Tests

KW - Prostate

KW - Prostatic Neoplasms

KW - Reproducibility of Results

KW - Sensitivity and Specificity

KW - Journal Article

U2 - 10.1016/j.juro.2015.12.086

DO - 10.1016/j.juro.2015.12.086

M3 - SCORING: Journal article

C2 - 26767519

VL - 195

SP - 1731

EP - 1736

JO - J UROLOGY

JF - J UROLOGY

SN - 0022-5347

IS - 6

ER -