Ligand-Receptor Interactions of Galectin-9 and VISTA Suppress Human T Lymphocyte Cytotoxic Activity
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Ligand-Receptor Interactions of Galectin-9 and VISTA Suppress Human T Lymphocyte Cytotoxic Activity. / Yasinska, Inna M; Meyer, N Helge; Schlichtner, Stephanie; Hussain, Rohanah; Siligardi, Giuliano; Casely-Hayford, Maxwell; Fiedler, Walter; Wellbrock, Jasmin; Desmet, Cloe; Calzolai, Luigi; Varani, Luca; Berger, Steffen M; Raap, Ulrike; Gibbs, Bernhard F; Fasler-Kan, Elizaveta; Sumbayev, Vadim V.
In: FRONT IMMUNOL, Vol. 11, 20.11.2020, p. 580557.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Ligand-Receptor Interactions of Galectin-9 and VISTA Suppress Human T Lymphocyte Cytotoxic Activity
AU - Yasinska, Inna M
AU - Meyer, N Helge
AU - Schlichtner, Stephanie
AU - Hussain, Rohanah
AU - Siligardi, Giuliano
AU - Casely-Hayford, Maxwell
AU - Fiedler, Walter
AU - Wellbrock, Jasmin
AU - Desmet, Cloe
AU - Calzolai, Luigi
AU - Varani, Luca
AU - Berger, Steffen M
AU - Raap, Ulrike
AU - Gibbs, Bernhard F
AU - Fasler-Kan, Elizaveta
AU - Sumbayev, Vadim V
N1 - Copyright © 2020 Yasinska, Meyer, Schlichtner, Hussain, Siligardi, Casely-Hayford, Fiedler, Wellbrock, Desmet, Calzolai, Varani, Berger, Raap, Gibbs, Fasler-Kan and Sumbayev.
PY - 2020/11/20
Y1 - 2020/11/20
N2 - Acute myeloid leukemia (AML), a blood/bone marrow cancer, is a severe and often fatal malignancy. AML cells are capable of impairing the anti-cancer activities of cytotoxic lymphoid cells. This includes the inactivation of natural killer (NK) cells and killing of T lymphocytes. Here we report for the first time that V-domain Ig-containing suppressor of T cell activation (VISTA), a protein expressed by T cells, recognizes galectin-9 secreted by AML cells as a ligand. Importantly, we found that soluble VISTA released by AML cells enhances the effect of galectin-9, most likely by forming multiprotein complexes on the surface of T cells and possibly creating a molecular barrier. These events cause changes in the plasma membrane potential of T cells leading to activation of granzyme B inside cytotoxic T cells, resulting in apoptosis.
AB - Acute myeloid leukemia (AML), a blood/bone marrow cancer, is a severe and often fatal malignancy. AML cells are capable of impairing the anti-cancer activities of cytotoxic lymphoid cells. This includes the inactivation of natural killer (NK) cells and killing of T lymphocytes. Here we report for the first time that V-domain Ig-containing suppressor of T cell activation (VISTA), a protein expressed by T cells, recognizes galectin-9 secreted by AML cells as a ligand. Importantly, we found that soluble VISTA released by AML cells enhances the effect of galectin-9, most likely by forming multiprotein complexes on the surface of T cells and possibly creating a molecular barrier. These events cause changes in the plasma membrane potential of T cells leading to activation of granzyme B inside cytotoxic T cells, resulting in apoptosis.
U2 - 10.3389/fimmu.2020.580557
DO - 10.3389/fimmu.2020.580557
M3 - SCORING: Journal article
C2 - 33329552
VL - 11
SP - 580557
JO - FRONT IMMUNOL
JF - FRONT IMMUNOL
SN - 1664-3224
ER -