Research ExplorerPublicationsLiberation of vessel-adherent myeloperoxidase reflects plaqu...

Liberation of vessel-adherent myeloperoxidase reflects plaque burden in patients with stable coronary artery disease

Standard

Liberation of vessel-adherent myeloperoxidase reflects plaque burden in patients with stable coronary artery disease. / Rudolph, Tanja K; Schaper, Neele; Klinke, Anna; Demir, Cagri; Goldmann, Britta; Lau, Denise; Köster, Ralf; Hellmich, Martin; Meinertz, Thomas; Baldus, Stephan; Rudolph, Volker.

In: ATHEROSCLEROSIS, Vol. 231, No. 2, 12.2013, p. 354-358.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research

Harvard

Rudolph, TK, Schaper, N, Klinke, A, Demir, C, Goldmann, B, Lau, D, Köster, R, Hellmich, M, Meinertz, T, Baldus, S & Rudolph, V 2013, 'Liberation of vessel-adherent myeloperoxidase reflects plaque burden in patients with stable coronary artery disease', ATHEROSCLEROSIS, vol. 231, no. 2, pp. 354-358. https://doi.org/10.1016/j.atherosclerosis.2013.09.016

APA

Rudolph, T. K., Schaper, N., Klinke, A., Demir, C., Goldmann, B., Lau, D., Köster, R., Hellmich, M., Meinertz, T., Baldus, S., & Rudolph, V. (2013). Liberation of vessel-adherent myeloperoxidase reflects plaque burden in patients with stable coronary artery disease. ATHEROSCLEROSIS, 231(2), 354-358. https://doi.org/10.1016/j.atherosclerosis.2013.09.016

Vancouver

Rudolph TK, Schaper N, Klinke A, Demir C, Goldmann B, Lau D et al. Liberation of vessel-adherent myeloperoxidase reflects plaque burden in patients with stable coronary artery disease. ATHEROSCLEROSIS. 2013 Dec;231(2):354-358. https://doi.org/10.1016/j.atherosclerosis.2013.09.016

Bibtex

@article{be9e177026aa4e109b116b6944710320,
title = "Liberation of vessel-adherent myeloperoxidase reflects plaque burden in patients with stable coronary artery disease",
abstract = "OBJECTIVE: Myeloperoxidase (MPO) has emerged as an important pathophysiological determinant of inflammatory vascular artery disease. It is appreciated that vessel immobilized, rather than circulating, MPO is critical for the progression of atherosclerotic lesions. The objective of this study was to investigate whether vessel-immobilized MPO is associated with the extent of coronary plaque burden.METHODS: MPO plasma levels were determined by ELISA before and after heparin-release of vessel-bound MPO, to study the relation between vascular MPO deposition and densitometrically assessed coronary plaque burden in 77 patients with stable coronary artery disease.RESULTS: Patients with a low increase in MPO plasma levels upon heparinization had a significantly smaller total plaque area and volume (12.1[IR:6.2-19.4]mm(2) vs. 19.8[IR:11.3-31.5]mm(2), p < 0.01; 27.8[IR:12.3-44.8]mm(3) vs. 55.2[IR:24.2-87.5]mm(3), p < 0.05). Multivariable linear regression revealed that ΔMPO was independently associated with plaque area, and that ΔMPO increased with the number of affected vessels. Selective sampling confirmed the predominant role of coronary MPO deposition.CONCLUSION: Our data demonstrate that heparin-induced mobilization of vessel-bound MPO is closely linked to coronary plaque burden and thus further corroborate the evidence for the intimate involvement of this enzyme in vascular pathophysiology, as well as the importance of inflammation in atherosclerosis.",
keywords = "Aged, Atherosclerosis, Coronary Artery Disease/blood, Coronary Vessels/pathology, Densitometry, Female, Heparin/chemistry, Humans, Inflammation, Male, Middle Aged, Peroxidase/blood, Plaque, Atherosclerotic/blood, Regression Analysis",
author = "Rudolph, {Tanja K} and Neele Schaper and Anna Klinke and Cagri Demir and Britta Goldmann and Denise Lau and Ralf K{\"o}ster and Martin Hellmich and Thomas Meinertz and Stephan Baldus and Volker Rudolph",
note = "Copyright {\textcopyright} 2013 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.",
year = "2013",
month = dec,
doi = "10.1016/j.atherosclerosis.2013.09.016",
language = "English",
volume = "231",
pages = "354--358",
journal = "ATHEROSCLEROSIS",
issn = "0021-9150",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - Liberation of vessel-adherent myeloperoxidase reflects plaque burden in patients with stable coronary artery disease

AU - Rudolph, Tanja K

AU - Schaper, Neele

AU - Klinke, Anna

AU - Demir, Cagri

AU - Goldmann, Britta

AU - Lau, Denise

AU - Köster, Ralf

AU - Hellmich, Martin

AU - Meinertz, Thomas

AU - Baldus, Stephan

AU - Rudolph, Volker

N1 - Copyright © 2013 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.

PY - 2013/12

Y1 - 2013/12

N2 - OBJECTIVE: Myeloperoxidase (MPO) has emerged as an important pathophysiological determinant of inflammatory vascular artery disease. It is appreciated that vessel immobilized, rather than circulating, MPO is critical for the progression of atherosclerotic lesions. The objective of this study was to investigate whether vessel-immobilized MPO is associated with the extent of coronary plaque burden.METHODS: MPO plasma levels were determined by ELISA before and after heparin-release of vessel-bound MPO, to study the relation between vascular MPO deposition and densitometrically assessed coronary plaque burden in 77 patients with stable coronary artery disease.RESULTS: Patients with a low increase in MPO plasma levels upon heparinization had a significantly smaller total plaque area and volume (12.1[IR:6.2-19.4]mm(2) vs. 19.8[IR:11.3-31.5]mm(2), p < 0.01; 27.8[IR:12.3-44.8]mm(3) vs. 55.2[IR:24.2-87.5]mm(3), p < 0.05). Multivariable linear regression revealed that ΔMPO was independently associated with plaque area, and that ΔMPO increased with the number of affected vessels. Selective sampling confirmed the predominant role of coronary MPO deposition.CONCLUSION: Our data demonstrate that heparin-induced mobilization of vessel-bound MPO is closely linked to coronary plaque burden and thus further corroborate the evidence for the intimate involvement of this enzyme in vascular pathophysiology, as well as the importance of inflammation in atherosclerosis.

AB - OBJECTIVE: Myeloperoxidase (MPO) has emerged as an important pathophysiological determinant of inflammatory vascular artery disease. It is appreciated that vessel immobilized, rather than circulating, MPO is critical for the progression of atherosclerotic lesions. The objective of this study was to investigate whether vessel-immobilized MPO is associated with the extent of coronary plaque burden.METHODS: MPO plasma levels were determined by ELISA before and after heparin-release of vessel-bound MPO, to study the relation between vascular MPO deposition and densitometrically assessed coronary plaque burden in 77 patients with stable coronary artery disease.RESULTS: Patients with a low increase in MPO plasma levels upon heparinization had a significantly smaller total plaque area and volume (12.1[IR:6.2-19.4]mm(2) vs. 19.8[IR:11.3-31.5]mm(2), p < 0.01; 27.8[IR:12.3-44.8]mm(3) vs. 55.2[IR:24.2-87.5]mm(3), p < 0.05). Multivariable linear regression revealed that ΔMPO was independently associated with plaque area, and that ΔMPO increased with the number of affected vessels. Selective sampling confirmed the predominant role of coronary MPO deposition.CONCLUSION: Our data demonstrate that heparin-induced mobilization of vessel-bound MPO is closely linked to coronary plaque burden and thus further corroborate the evidence for the intimate involvement of this enzyme in vascular pathophysiology, as well as the importance of inflammation in atherosclerosis.

KW - Aged

KW - Atherosclerosis

KW - Coronary Artery Disease/blood

KW - Coronary Vessels/pathology

KW - Densitometry

KW - Female

KW - Heparin/chemistry

KW - Humans

KW - Inflammation

KW - Male

KW - Middle Aged

KW - Peroxidase/blood

KW - Plaque, Atherosclerotic/blood

KW - Regression Analysis

U2 - 10.1016/j.atherosclerosis.2013.09.016

DO - 10.1016/j.atherosclerosis.2013.09.016

M3 - SCORING: Journal article

C2 - 24267251

VL - 231

SP - 354

EP - 358

JO - ATHEROSCLEROSIS

JF - ATHEROSCLEROSIS

SN - 0021-9150

IS - 2

ER -