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"Let's see what happens:"-Women's experiences of open-label placebo treatment for menopausal hot flushes in a randomized controlled trial

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"Let's see what happens:"-Women's experiences of open-label placebo treatment for menopausal hot flushes in a randomized controlled trial. / Pan, Yiqi; Frank, Miriam L; Kaptchuk, Ted J; Nestoriuc, Yvonne.

In: PLOS ONE, Vol. 17, No. 11, e0276499, 2022.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Pan, Y, Frank, ML, Kaptchuk, TJ & Nestoriuc, Y 2022, '"Let's see what happens:"-Women's experiences of open-label placebo treatment for menopausal hot flushes in a randomized controlled trial', PLOS ONE, vol. 17, no. 11, e0276499. https://doi.org/10.1371/journal.pone.0276499

APA

Pan, Y., Frank, M. L., Kaptchuk, T. J., & Nestoriuc, Y. (2022). "Let's see what happens:"-Women's experiences of open-label placebo treatment for menopausal hot flushes in a randomized controlled trial. PLOS ONE, 17(11), [e0276499]. https://doi.org/10.1371/journal.pone.0276499

Vancouver

Pan Y, Frank ML, Kaptchuk TJ, Nestoriuc Y. "Let's see what happens:"-Women's experiences of open-label placebo treatment for menopausal hot flushes in a randomized controlled trial. PLOS ONE. 2022;17(11). e0276499. https://doi.org/10.1371/journal.pone.0276499

Bibtex

@article{fcc98057749344f0bc74e05ed85853e3,
title = "{"}Let's see what happens:{"}-Women's experiences of open-label placebo treatment for menopausal hot flushes in a randomized controlled trial",
abstract = "Open-label (honestly prescribed) placebos are an ethical way to evoke placebo effects in patients. As part of a mixed-methods study, we conducted in-depth interviews with eight menopausal women who underwent and benefitted from open-label placebo treatment in a randomized-controlled trial of hot flushes. Data were analyzed using Interpretative Phenomenological Analysis. We found that the women had low expectations about the placebo treatment yet endorsed what they referred to as {"}hope{"} and openness to {"}see what happens{"}. Recording hot flushes via the symptom diary was viewed as a valuable opportunity for self-examination and appraising outcomes. Receiving relief from the placebo treatment empowered women and enhanced their sense of control and agency. In summary, participants' initial openness towards placebos, their hopes to get better, monitoring symptoms closely, and taking the initiative to address symptoms were components of a positive open-label placebo experience.",
keywords = "Humans, Female, Hot Flashes/drug therapy, Menopause, Double-Blind Method",
author = "Yiqi Pan and Frank, {Miriam L} and Kaptchuk, {Ted J} and Yvonne Nestoriuc",
note = "Copyright: {\textcopyright} 2022 Pan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",
year = "2022",
doi = "10.1371/journal.pone.0276499",
language = "English",
volume = "17",
journal = "PLOS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "11",

}

RIS

TY - JOUR

T1 - "Let's see what happens:"-Women's experiences of open-label placebo treatment for menopausal hot flushes in a randomized controlled trial

AU - Pan, Yiqi

AU - Frank, Miriam L

AU - Kaptchuk, Ted J

AU - Nestoriuc, Yvonne

N1 - Copyright: © 2022 Pan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PY - 2022

Y1 - 2022

N2 - Open-label (honestly prescribed) placebos are an ethical way to evoke placebo effects in patients. As part of a mixed-methods study, we conducted in-depth interviews with eight menopausal women who underwent and benefitted from open-label placebo treatment in a randomized-controlled trial of hot flushes. Data were analyzed using Interpretative Phenomenological Analysis. We found that the women had low expectations about the placebo treatment yet endorsed what they referred to as "hope" and openness to "see what happens". Recording hot flushes via the symptom diary was viewed as a valuable opportunity for self-examination and appraising outcomes. Receiving relief from the placebo treatment empowered women and enhanced their sense of control and agency. In summary, participants' initial openness towards placebos, their hopes to get better, monitoring symptoms closely, and taking the initiative to address symptoms were components of a positive open-label placebo experience.

AB - Open-label (honestly prescribed) placebos are an ethical way to evoke placebo effects in patients. As part of a mixed-methods study, we conducted in-depth interviews with eight menopausal women who underwent and benefitted from open-label placebo treatment in a randomized-controlled trial of hot flushes. Data were analyzed using Interpretative Phenomenological Analysis. We found that the women had low expectations about the placebo treatment yet endorsed what they referred to as "hope" and openness to "see what happens". Recording hot flushes via the symptom diary was viewed as a valuable opportunity for self-examination and appraising outcomes. Receiving relief from the placebo treatment empowered women and enhanced their sense of control and agency. In summary, participants' initial openness towards placebos, their hopes to get better, monitoring symptoms closely, and taking the initiative to address symptoms were components of a positive open-label placebo experience.

KW - Humans

KW - Female

KW - Hot Flashes/drug therapy

KW - Menopause

KW - Double-Blind Method

U2 - 10.1371/journal.pone.0276499

DO - 10.1371/journal.pone.0276499

M3 - SCORING: Journal article

C2 - 36331921

VL - 17

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 11

M1 - e0276499

ER -