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Leptin and the Skin: a new frontier

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Leptin and the Skin: a new frontier. / Poeggeler, Burkhard; Schulz, Carla; Pappolla, Miguel A; Bodó, Eniko; Tiede, Stephan; Lehnert, Hendrik; Paus, Ralf.

In: EXP DERMATOL, Vol. 19, No. 1, 01.2010, p. 12-8.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Poeggeler, B, Schulz, C, Pappolla, MA, Bodó, E, Tiede, S, Lehnert, H & Paus, R 2010, 'Leptin and the Skin: a new frontier', EXP DERMATOL, vol. 19, no. 1, pp. 12-8. https://doi.org/10.1111/j.1600-0625.2009.00930.x

APA

Poeggeler, B., Schulz, C., Pappolla, M. A., Bodó, E., Tiede, S., Lehnert, H., & Paus, R. (2010). Leptin and the Skin: a new frontier. EXP DERMATOL, 19(1), 12-8. https://doi.org/10.1111/j.1600-0625.2009.00930.x

Vancouver

Poeggeler B, Schulz C, Pappolla MA, Bodó E, Tiede S, Lehnert H et al. Leptin and the Skin: a new frontier. EXP DERMATOL. 2010 Jan;19(1):12-8. https://doi.org/10.1111/j.1600-0625.2009.00930.x

Bibtex

@article{8c45e2c27ca748a9839c3638536278cd,
title = "Leptin and the Skin: a new frontier",
abstract = "Here, we examine the currently available information which supports that the adipokine, leptin, is a major player in the biology and pathology of mammalian skin and its appendages. Specifically, the potent metabolic effects of leptin and its mimetics may be utilized to improve, preserve and restore skin regeneration and hair cycle progression, and may halt or even partially reverse some aspects of skin ageing. Since leptin can enhance mitochondrial activity and biogenesis, this may contribute to the wound healing-promoting and hair growth-modulatory effects of leptin. Leptin dependent intracellular signalling by the Janus kinase 2 dependent signal transducer and activator of transcription 3, adenosine monophosphate kinase, and peroxisome proliferator-activated receptor (PPAR) gamma coactivator/PPAR converges to mediate mitochondrial metabolic activation and enhanced cell proliferation which may orchestrate the potent developmental, trophic and protective effects of leptin. Since leptin and leptin mimetics have already been clinically tested, investigative dermatology is well-advised to place greater emphasis on the systematic exploration of the cutaneous dimensions and dermatological potential of this pleiotropic hormone.",
keywords = "Animals, Hair, Humans, Leptin, Signal Transduction, Skin, Skin Neoplasms, Wound Healing, Journal Article, Research Support, Non-U.S. Gov't, Review",
author = "Burkhard Poeggeler and Carla Schulz and Pappolla, {Miguel A} and Eniko Bod{\'o} and Stephan Tiede and Hendrik Lehnert and Ralf Paus",
year = "2010",
month = jan,
doi = "10.1111/j.1600-0625.2009.00930.x",
language = "English",
volume = "19",
pages = "12--8",
journal = "EXP DERMATOL",
issn = "0906-6705",
publisher = "Wiley-Blackwell",
number = "1",

}

RIS

TY - JOUR

T1 - Leptin and the Skin: a new frontier

AU - Poeggeler, Burkhard

AU - Schulz, Carla

AU - Pappolla, Miguel A

AU - Bodó, Eniko

AU - Tiede, Stephan

AU - Lehnert, Hendrik

AU - Paus, Ralf

PY - 2010/1

Y1 - 2010/1

N2 - Here, we examine the currently available information which supports that the adipokine, leptin, is a major player in the biology and pathology of mammalian skin and its appendages. Specifically, the potent metabolic effects of leptin and its mimetics may be utilized to improve, preserve and restore skin regeneration and hair cycle progression, and may halt or even partially reverse some aspects of skin ageing. Since leptin can enhance mitochondrial activity and biogenesis, this may contribute to the wound healing-promoting and hair growth-modulatory effects of leptin. Leptin dependent intracellular signalling by the Janus kinase 2 dependent signal transducer and activator of transcription 3, adenosine monophosphate kinase, and peroxisome proliferator-activated receptor (PPAR) gamma coactivator/PPAR converges to mediate mitochondrial metabolic activation and enhanced cell proliferation which may orchestrate the potent developmental, trophic and protective effects of leptin. Since leptin and leptin mimetics have already been clinically tested, investigative dermatology is well-advised to place greater emphasis on the systematic exploration of the cutaneous dimensions and dermatological potential of this pleiotropic hormone.

AB - Here, we examine the currently available information which supports that the adipokine, leptin, is a major player in the biology and pathology of mammalian skin and its appendages. Specifically, the potent metabolic effects of leptin and its mimetics may be utilized to improve, preserve and restore skin regeneration and hair cycle progression, and may halt or even partially reverse some aspects of skin ageing. Since leptin can enhance mitochondrial activity and biogenesis, this may contribute to the wound healing-promoting and hair growth-modulatory effects of leptin. Leptin dependent intracellular signalling by the Janus kinase 2 dependent signal transducer and activator of transcription 3, adenosine monophosphate kinase, and peroxisome proliferator-activated receptor (PPAR) gamma coactivator/PPAR converges to mediate mitochondrial metabolic activation and enhanced cell proliferation which may orchestrate the potent developmental, trophic and protective effects of leptin. Since leptin and leptin mimetics have already been clinically tested, investigative dermatology is well-advised to place greater emphasis on the systematic exploration of the cutaneous dimensions and dermatological potential of this pleiotropic hormone.

KW - Animals

KW - Hair

KW - Humans

KW - Leptin

KW - Signal Transduction

KW - Skin

KW - Skin Neoplasms

KW - Wound Healing

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Review

U2 - 10.1111/j.1600-0625.2009.00930.x

DO - 10.1111/j.1600-0625.2009.00930.x

M3 - SCORING: Review article

C2 - 19601981

VL - 19

SP - 12

EP - 18

JO - EXP DERMATOL

JF - EXP DERMATOL

SN - 0906-6705

IS - 1

ER -