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Leptin: a modulator of alcohol craving?

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Leptin: a modulator of alcohol craving? / Kiefer, F; Jahn, Holger; Jaschinski, M; Holzbach, R; Wolf, K; Naber, Dieter; Wiedemann, Klaus.

In: BIOL PSYCHIAT, Vol. 49, No. 9, 9, 2001, p. 782-787.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kiefer, F, Jahn, H, Jaschinski, M, Holzbach, R, Wolf, K, Naber, D & Wiedemann, K 2001, 'Leptin: a modulator of alcohol craving?', BIOL PSYCHIAT, vol. 49, no. 9, 9, pp. 782-787. <http://www.ncbi.nlm.nih.gov/pubmed/11331086?dopt=Citation>

APA

Kiefer, F., Jahn, H., Jaschinski, M., Holzbach, R., Wolf, K., Naber, D., & Wiedemann, K. (2001). Leptin: a modulator of alcohol craving? BIOL PSYCHIAT, 49(9), 782-787. [9]. http://www.ncbi.nlm.nih.gov/pubmed/11331086?dopt=Citation

Vancouver

Kiefer F, Jahn H, Jaschinski M, Holzbach R, Wolf K, Naber D et al. Leptin: a modulator of alcohol craving? BIOL PSYCHIAT. 2001;49(9):782-787. 9.

Bibtex

@article{c6c8315f265343aba73e3db73d24731b,
title = "Leptin: a modulator of alcohol craving?",
abstract = "BACKGROUND: Leptin has been shown to regulate food intake and energy expenditure. Because leptin acts via regulation of appetite, we studied the hypothesis that suggests leptin modulates craving for alcohol as well. METHODS: We studied leptin plasma concentrations (RIA) both in alcoholic subjects during inpatient detoxification (day 1: n = 78, day 14: n = 60) and in healthy control subjects (n = 30). To rule out interference with the activation of the HPA axis during alcohol withdrawal, we also evaluated cortisol plasma levels (RIA). RESULTS: We found plasma leptin and cortisol elevated at onset of withdrawal, decreasing significantly up to day 14. Leptin (and the body-mass corrected ratio leptin/BMI) was highly correlated with self-rated craving. No correlations of craving with cortisol and BMI were observed. CONCLUSIONS: We suggest that leptin may modulate withdrawal-induced craving in alcoholic subjects.",
author = "F Kiefer and Holger Jahn and M Jaschinski and R Holzbach and K Wolf and Dieter Naber and Klaus Wiedemann",
year = "2001",
language = "Deutsch",
volume = "49",
pages = "782--787",
journal = "BIOL PSYCHIAT",
issn = "0006-3223",
publisher = "Elsevier USA",
number = "9",

}

RIS

TY - JOUR

T1 - Leptin: a modulator of alcohol craving?

AU - Kiefer, F

AU - Jahn, Holger

AU - Jaschinski, M

AU - Holzbach, R

AU - Wolf, K

AU - Naber, Dieter

AU - Wiedemann, Klaus

PY - 2001

Y1 - 2001

N2 - BACKGROUND: Leptin has been shown to regulate food intake and energy expenditure. Because leptin acts via regulation of appetite, we studied the hypothesis that suggests leptin modulates craving for alcohol as well. METHODS: We studied leptin plasma concentrations (RIA) both in alcoholic subjects during inpatient detoxification (day 1: n = 78, day 14: n = 60) and in healthy control subjects (n = 30). To rule out interference with the activation of the HPA axis during alcohol withdrawal, we also evaluated cortisol plasma levels (RIA). RESULTS: We found plasma leptin and cortisol elevated at onset of withdrawal, decreasing significantly up to day 14. Leptin (and the body-mass corrected ratio leptin/BMI) was highly correlated with self-rated craving. No correlations of craving with cortisol and BMI were observed. CONCLUSIONS: We suggest that leptin may modulate withdrawal-induced craving in alcoholic subjects.

AB - BACKGROUND: Leptin has been shown to regulate food intake and energy expenditure. Because leptin acts via regulation of appetite, we studied the hypothesis that suggests leptin modulates craving for alcohol as well. METHODS: We studied leptin plasma concentrations (RIA) both in alcoholic subjects during inpatient detoxification (day 1: n = 78, day 14: n = 60) and in healthy control subjects (n = 30). To rule out interference with the activation of the HPA axis during alcohol withdrawal, we also evaluated cortisol plasma levels (RIA). RESULTS: We found plasma leptin and cortisol elevated at onset of withdrawal, decreasing significantly up to day 14. Leptin (and the body-mass corrected ratio leptin/BMI) was highly correlated with self-rated craving. No correlations of craving with cortisol and BMI were observed. CONCLUSIONS: We suggest that leptin may modulate withdrawal-induced craving in alcoholic subjects.

M3 - SCORING: Zeitschriftenaufsatz

VL - 49

SP - 782

EP - 787

JO - BIOL PSYCHIAT

JF - BIOL PSYCHIAT

SN - 0006-3223

IS - 9

M1 - 9

ER -