Left Ventricular Diastolic Dysfunction Is Not Associated With Pulmonary Edema in Septic Patients. A Prospective Observational Cohort Study
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Left Ventricular Diastolic Dysfunction Is Not Associated With Pulmonary Edema in Septic Patients. A Prospective Observational Cohort Study. / Kahl, Ursula; Schirren, Leah; Yu, Yuanyuan; Lezius, Susanne; Fischer, Marlene; Menke, Maja; Sinning, Christoph; Nierhaus, Axel; Vens, Maren; Zöllner, Christian; Kluge, Stefan; Goepfert, Matthias S; Roeher, Katharina.
In: FRONT CARDIOVASC MED, Vol. 9, 900850, 2022.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Left Ventricular Diastolic Dysfunction Is Not Associated With Pulmonary Edema in Septic Patients. A Prospective Observational Cohort Study
AU - Kahl, Ursula
AU - Schirren, Leah
AU - Yu, Yuanyuan
AU - Lezius, Susanne
AU - Fischer, Marlene
AU - Menke, Maja
AU - Sinning, Christoph
AU - Nierhaus, Axel
AU - Vens, Maren
AU - Zöllner, Christian
AU - Kluge, Stefan
AU - Goepfert, Matthias S
AU - Roeher, Katharina
N1 - Copyright © 2022 Kahl, Schirren, Yu, Lezius, Fischer, Menke, Sinning, Nierhaus, Vens, Zöllner, Kluge, Goepfert and Roeher.
PY - 2022
Y1 - 2022
N2 - Purpose: We aimed to investigate whether left ventricular diastolic dysfunction (LVDD) is associated with pulmonary edema in septic patients.Methods: We conducted a prospective cohort study in adult septic patients between October 2018 and May 2019. We performed repeated echocardiography and lung ultrasound examinations within the first 7 days after diagnosis of sepsis. We defined LVDD according to the 2016 recommendations of the American Society of Echocardiography and-for sensitivity analysis-according to an algorithm which has been validated in septic patients. We quantified pulmonary edema using the lung ultrasound score (LUSS), counting B-lines in four intercostal spaces.Results: We included 54 patients. LVDD was present in 51 (42%) of 122 echocardiography examinations. The mean (±SD) LUSS was 11 ± 6. There was no clinically meaningful association of LVDD with LUSS (B = 0.55 [95%CI: -1.38; 2.47]; p = 0.571). Pneumonia was significantly associated with higher LUSS (B = 4.42 [95%CI: 0.38; 8.5]; p = 0.033).Conclusion: The lack of a clinically meaningful association of LVDD with LUSS suggests that LVDD is not a major contributor to pulmonary edema in septic patients.Trial Registration: NCT03768752, ClinicalTrials.gov, November 30th, 2018 - retrospectively registered.
AB - Purpose: We aimed to investigate whether left ventricular diastolic dysfunction (LVDD) is associated with pulmonary edema in septic patients.Methods: We conducted a prospective cohort study in adult septic patients between October 2018 and May 2019. We performed repeated echocardiography and lung ultrasound examinations within the first 7 days after diagnosis of sepsis. We defined LVDD according to the 2016 recommendations of the American Society of Echocardiography and-for sensitivity analysis-according to an algorithm which has been validated in septic patients. We quantified pulmonary edema using the lung ultrasound score (LUSS), counting B-lines in four intercostal spaces.Results: We included 54 patients. LVDD was present in 51 (42%) of 122 echocardiography examinations. The mean (±SD) LUSS was 11 ± 6. There was no clinically meaningful association of LVDD with LUSS (B = 0.55 [95%CI: -1.38; 2.47]; p = 0.571). Pneumonia was significantly associated with higher LUSS (B = 4.42 [95%CI: 0.38; 8.5]; p = 0.033).Conclusion: The lack of a clinically meaningful association of LVDD with LUSS suggests that LVDD is not a major contributor to pulmonary edema in septic patients.Trial Registration: NCT03768752, ClinicalTrials.gov, November 30th, 2018 - retrospectively registered.
U2 - 10.3389/fcvm.2022.900850
DO - 10.3389/fcvm.2022.900850
M3 - SCORING: Journal article
C2 - 35845063
VL - 9
JO - FRONT CARDIOVASC MED
JF - FRONT CARDIOVASC MED
SN - 2297-055X
M1 - 900850
ER -
