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Left atrial active contractile function parameters assessed by cardiac MR are sensitive to myocardial iron

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Left atrial active contractile function parameters assessed by cardiac MR are sensitive to myocardial iron. / Wehbe, Mahmoud; Yamamura, Jin; Fischer, Roland; Grosse, Regine; Berliner, Christoph; Graessner, Joachim; Lund, Gunnar; Adam, Gerhard; Schoennagel, Bjoern P.

In: J MAGN RESON IMAGING, Vol. 45, No. 2, 02.2017, p. 535-541.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Wehbe, M, Yamamura, J, Fischer, R, Grosse, R, Berliner, C, Graessner, J, Lund, G, Adam, G & Schoennagel, BP 2017, 'Left atrial active contractile function parameters assessed by cardiac MR are sensitive to myocardial iron', J MAGN RESON IMAGING, vol. 45, no. 2, pp. 535-541. https://doi.org/10.1002/jmri.25396

APA

Wehbe, M., Yamamura, J., Fischer, R., Grosse, R., Berliner, C., Graessner, J., Lund, G., Adam, G., & Schoennagel, B. P. (2017). Left atrial active contractile function parameters assessed by cardiac MR are sensitive to myocardial iron. J MAGN RESON IMAGING, 45(2), 535-541. https://doi.org/10.1002/jmri.25396

Vancouver

Wehbe M, Yamamura J, Fischer R, Grosse R, Berliner C, Graessner J et al. Left atrial active contractile function parameters assessed by cardiac MR are sensitive to myocardial iron. J MAGN RESON IMAGING. 2017 Feb;45(2):535-541. https://doi.org/10.1002/jmri.25396

Bibtex

@article{63ab8067a94643fab420f7c3d13949cb,
title = "Left atrial active contractile function parameters assessed by cardiac MR are sensitive to myocardial iron",
abstract = "PURPOSE: To determine the impact of myocardial iron overload on left atrial (LA) volume and function using MR in patients with systemic iron overload.MATERIALS AND METHODS: Thirty-eight patients with systemic iron overload disease and 10 controls underwent 1.5 Tesla MR performing steady state free precession short-axis cine-series of the LA. Three-dimensional-volumetry was assessed to calculate LA volumes and function. Parameters were indexed (i) to body surface area. The myocardial transverse relaxation rate R2* was determined in the ventricular septum using a multi-echo GRE sequence (breathhold; electrocardiography triggered; 12 echoes; echo time = 1.3-25.7 ms).RESULTS: Significantly decreased active atrial emptying fraction (AAEF) (23% [95%-range, 7-34] versus 36% [95%-range, 14-49], P = 0.009), active atrial emptying volume (AAEVi) (5.5 mL/m(2) [95%-range, 2-11] versus 11.9 mL/m(2) [95%-range, 3-23], P = 0.008), and active peak emptying rate (APERi) (46 mL/s/m(2) [95%-range, 29-69] versus 75 mL/s/m(2) [95%-range, 45-178], P < 0.001) were found for patients with myocardial iron overload (R2* > 40 s(-1) ) compared with patients with normal myocardial iron levels (R2* < 40 s(-1) ). Receiver operating characteristics (ROC) analysis revealed higher potential to indicate myocardial iron overload for the AAEF (area under the ROC curve [AUC] = 0.84; P < 0.0001), APERi (AUC = 0.87; P < 0.0001), and AAEVi (AUC = 0.80; P < 0.0001) compared with LA ejection fraction (LAEF) (AUC = 0.68; P = 0.02) with equal sensitivities and specificities of 82% (AAEF), 79% (APERi), 73% (AAEVi), and 57% (LAEF).CONCLUSION: MR parameters of active LA contractile function were associated with myocardial iron overload. This cross-sectional study suggests impaired active LA contractile function to be sensitive to myocardial iron toxicity. J. Magn. Reson. Imaging 2016.",
author = "Mahmoud Wehbe and Jin Yamamura and Roland Fischer and Regine Grosse and Christoph Berliner and Joachim Graessner and Gunnar Lund and Gerhard Adam and Schoennagel, {Bjoern P}",
note = "{\textcopyright} 2016 International Society for Magnetic Resonance in Medicine.",
year = "2017",
month = feb,
doi = "10.1002/jmri.25396",
language = "English",
volume = "45",
pages = "535--541",
journal = "J MAGN RESON IMAGING",
issn = "1053-1807",
publisher = "John Wiley and Sons Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Left atrial active contractile function parameters assessed by cardiac MR are sensitive to myocardial iron

AU - Wehbe, Mahmoud

AU - Yamamura, Jin

AU - Fischer, Roland

AU - Grosse, Regine

AU - Berliner, Christoph

AU - Graessner, Joachim

AU - Lund, Gunnar

AU - Adam, Gerhard

AU - Schoennagel, Bjoern P

N1 - © 2016 International Society for Magnetic Resonance in Medicine.

PY - 2017/2

Y1 - 2017/2

N2 - PURPOSE: To determine the impact of myocardial iron overload on left atrial (LA) volume and function using MR in patients with systemic iron overload.MATERIALS AND METHODS: Thirty-eight patients with systemic iron overload disease and 10 controls underwent 1.5 Tesla MR performing steady state free precession short-axis cine-series of the LA. Three-dimensional-volumetry was assessed to calculate LA volumes and function. Parameters were indexed (i) to body surface area. The myocardial transverse relaxation rate R2* was determined in the ventricular septum using a multi-echo GRE sequence (breathhold; electrocardiography triggered; 12 echoes; echo time = 1.3-25.7 ms).RESULTS: Significantly decreased active atrial emptying fraction (AAEF) (23% [95%-range, 7-34] versus 36% [95%-range, 14-49], P = 0.009), active atrial emptying volume (AAEVi) (5.5 mL/m(2) [95%-range, 2-11] versus 11.9 mL/m(2) [95%-range, 3-23], P = 0.008), and active peak emptying rate (APERi) (46 mL/s/m(2) [95%-range, 29-69] versus 75 mL/s/m(2) [95%-range, 45-178], P < 0.001) were found for patients with myocardial iron overload (R2* > 40 s(-1) ) compared with patients with normal myocardial iron levels (R2* < 40 s(-1) ). Receiver operating characteristics (ROC) analysis revealed higher potential to indicate myocardial iron overload for the AAEF (area under the ROC curve [AUC] = 0.84; P < 0.0001), APERi (AUC = 0.87; P < 0.0001), and AAEVi (AUC = 0.80; P < 0.0001) compared with LA ejection fraction (LAEF) (AUC = 0.68; P = 0.02) with equal sensitivities and specificities of 82% (AAEF), 79% (APERi), 73% (AAEVi), and 57% (LAEF).CONCLUSION: MR parameters of active LA contractile function were associated with myocardial iron overload. This cross-sectional study suggests impaired active LA contractile function to be sensitive to myocardial iron toxicity. J. Magn. Reson. Imaging 2016.

AB - PURPOSE: To determine the impact of myocardial iron overload on left atrial (LA) volume and function using MR in patients with systemic iron overload.MATERIALS AND METHODS: Thirty-eight patients with systemic iron overload disease and 10 controls underwent 1.5 Tesla MR performing steady state free precession short-axis cine-series of the LA. Three-dimensional-volumetry was assessed to calculate LA volumes and function. Parameters were indexed (i) to body surface area. The myocardial transverse relaxation rate R2* was determined in the ventricular septum using a multi-echo GRE sequence (breathhold; electrocardiography triggered; 12 echoes; echo time = 1.3-25.7 ms).RESULTS: Significantly decreased active atrial emptying fraction (AAEF) (23% [95%-range, 7-34] versus 36% [95%-range, 14-49], P = 0.009), active atrial emptying volume (AAEVi) (5.5 mL/m(2) [95%-range, 2-11] versus 11.9 mL/m(2) [95%-range, 3-23], P = 0.008), and active peak emptying rate (APERi) (46 mL/s/m(2) [95%-range, 29-69] versus 75 mL/s/m(2) [95%-range, 45-178], P < 0.001) were found for patients with myocardial iron overload (R2* > 40 s(-1) ) compared with patients with normal myocardial iron levels (R2* < 40 s(-1) ). Receiver operating characteristics (ROC) analysis revealed higher potential to indicate myocardial iron overload for the AAEF (area under the ROC curve [AUC] = 0.84; P < 0.0001), APERi (AUC = 0.87; P < 0.0001), and AAEVi (AUC = 0.80; P < 0.0001) compared with LA ejection fraction (LAEF) (AUC = 0.68; P = 0.02) with equal sensitivities and specificities of 82% (AAEF), 79% (APERi), 73% (AAEVi), and 57% (LAEF).CONCLUSION: MR parameters of active LA contractile function were associated with myocardial iron overload. This cross-sectional study suggests impaired active LA contractile function to be sensitive to myocardial iron toxicity. J. Magn. Reson. Imaging 2016.

U2 - 10.1002/jmri.25396

DO - 10.1002/jmri.25396

M3 - SCORING: Journal article

C2 - 27459111

VL - 45

SP - 535

EP - 541

JO - J MAGN RESON IMAGING

JF - J MAGN RESON IMAGING

SN - 1053-1807

IS - 2

ER -