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Leda-1/Pianp is targeted to the basolateral plasma membrane by a distinct intracellular juxtamembrane region and modulates barrier properties and E-Cadherin processing

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Leda-1/Pianp is targeted to the basolateral plasma membrane by a distinct intracellular juxtamembrane region and modulates barrier properties and E-Cadherin processing. / Evdokimov, Konstantin; Biswas, Siladitta; Schledzewski, Kai; Winkler, Manuel; Gorzelanny, Christian; Schneider, Stefan W; Goerdt, Sergij; Géraud, Cyrill.

In: BIOCHEM BIOPH RES CO, Vol. 475, No. 4, 08.07.2016, p. 342-9.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Evdokimov, K, Biswas, S, Schledzewski, K, Winkler, M, Gorzelanny, C, Schneider, SW, Goerdt, S & Géraud, C 2016, 'Leda-1/Pianp is targeted to the basolateral plasma membrane by a distinct intracellular juxtamembrane region and modulates barrier properties and E-Cadherin processing', BIOCHEM BIOPH RES CO, vol. 475, no. 4, pp. 342-9. https://doi.org/10.1016/j.bbrc.2016.05.092

APA

Evdokimov, K., Biswas, S., Schledzewski, K., Winkler, M., Gorzelanny, C., Schneider, S. W., Goerdt, S., & Géraud, C. (2016). Leda-1/Pianp is targeted to the basolateral plasma membrane by a distinct intracellular juxtamembrane region and modulates barrier properties and E-Cadherin processing. BIOCHEM BIOPH RES CO, 475(4), 342-9. https://doi.org/10.1016/j.bbrc.2016.05.092

Vancouver

Evdokimov K, Biswas S, Schledzewski K, Winkler M, Gorzelanny C, Schneider SW et al. Leda-1/Pianp is targeted to the basolateral plasma membrane by a distinct intracellular juxtamembrane region and modulates barrier properties and E-Cadherin processing. BIOCHEM BIOPH RES CO. 2016 Jul 8;475(4):342-9. https://doi.org/10.1016/j.bbrc.2016.05.092

Bibtex

@article{cc48a22903214d1bbaa46a2cb70c4247,
title = "Leda-1/Pianp is targeted to the basolateral plasma membrane by a distinct intracellular juxtamembrane region and modulates barrier properties and E-Cadherin processing",
abstract = "Leda-1/Pianp is a type-I transmembrane protein which is sorted to the basolateral membrane domain of polarized epithelial cells. Here, we investigated trafficking mechanisms and functions of Leda-1/Pianp in MDCK and MCF-7 cells. Basolateral sorting and posttranslational modifications depended on the intracellular juxtamembrane region. Functionally, Leda-1/Pianp increased the transepithelial electrical resistance generated by a polarized cell sheet. Furthermore, resistance to junctional destabilization by tumor cells was enhanced by Leda-1/Pianp indicating increased stability and tightness of intercellular junctions. While Claudin 1 and 4 expression and activities of small GTPases were not affected, γ-Secretase-mediated cleavage of E-Cadherin was attenuated by Leda-1/Pianp. Regulation of proteolytic processing is thus a molecular mechanism by which Leda-1/Pianp can affect junctional integrity and function.",
keywords = "Journal Article",
author = "Konstantin Evdokimov and Siladitta Biswas and Kai Schledzewski and Manuel Winkler and Christian Gorzelanny and Schneider, {Stefan W} and Sergij Goerdt and Cyrill G{\'e}raud",
note = "Copyright {\textcopyright} 2016 Elsevier Inc. All rights reserved.",
year = "2016",
month = jul,
day = "8",
doi = "10.1016/j.bbrc.2016.05.092",
language = "English",
volume = "475",
pages = "342--9",
journal = "BIOCHEM BIOPH RES CO",
issn = "0006-291X",
publisher = "Academic Press Inc.",
number = "4",

}

RIS

TY - JOUR

T1 - Leda-1/Pianp is targeted to the basolateral plasma membrane by a distinct intracellular juxtamembrane region and modulates barrier properties and E-Cadherin processing

AU - Evdokimov, Konstantin

AU - Biswas, Siladitta

AU - Schledzewski, Kai

AU - Winkler, Manuel

AU - Gorzelanny, Christian

AU - Schneider, Stefan W

AU - Goerdt, Sergij

AU - Géraud, Cyrill

N1 - Copyright © 2016 Elsevier Inc. All rights reserved.

PY - 2016/7/8

Y1 - 2016/7/8

N2 - Leda-1/Pianp is a type-I transmembrane protein which is sorted to the basolateral membrane domain of polarized epithelial cells. Here, we investigated trafficking mechanisms and functions of Leda-1/Pianp in MDCK and MCF-7 cells. Basolateral sorting and posttranslational modifications depended on the intracellular juxtamembrane region. Functionally, Leda-1/Pianp increased the transepithelial electrical resistance generated by a polarized cell sheet. Furthermore, resistance to junctional destabilization by tumor cells was enhanced by Leda-1/Pianp indicating increased stability and tightness of intercellular junctions. While Claudin 1 and 4 expression and activities of small GTPases were not affected, γ-Secretase-mediated cleavage of E-Cadherin was attenuated by Leda-1/Pianp. Regulation of proteolytic processing is thus a molecular mechanism by which Leda-1/Pianp can affect junctional integrity and function.

AB - Leda-1/Pianp is a type-I transmembrane protein which is sorted to the basolateral membrane domain of polarized epithelial cells. Here, we investigated trafficking mechanisms and functions of Leda-1/Pianp in MDCK and MCF-7 cells. Basolateral sorting and posttranslational modifications depended on the intracellular juxtamembrane region. Functionally, Leda-1/Pianp increased the transepithelial electrical resistance generated by a polarized cell sheet. Furthermore, resistance to junctional destabilization by tumor cells was enhanced by Leda-1/Pianp indicating increased stability and tightness of intercellular junctions. While Claudin 1 and 4 expression and activities of small GTPases were not affected, γ-Secretase-mediated cleavage of E-Cadherin was attenuated by Leda-1/Pianp. Regulation of proteolytic processing is thus a molecular mechanism by which Leda-1/Pianp can affect junctional integrity and function.

KW - Journal Article

U2 - 10.1016/j.bbrc.2016.05.092

DO - 10.1016/j.bbrc.2016.05.092

M3 - SCORING: Journal article

C2 - 27216462

VL - 475

SP - 342

EP - 349

JO - BIOCHEM BIOPH RES CO

JF - BIOCHEM BIOPH RES CO

SN - 0006-291X

IS - 4

ER -