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Lectin Histochemistry Shows WGA, PHA-L and HPA Binding Increases During Progression of Human Colorectal Cancer

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Lectin Histochemistry Shows WGA, PHA-L and HPA Binding Increases During Progression of Human Colorectal Cancer. / Hägerbäumer, Pia; Vieth, Michael; Anders, Mario; Schumacher, Udo.

In: ANTICANCER RES, Vol. 35, No. 10, 10.2015, p. 5333-9.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Hägerbäumer, P, Vieth, M, Anders, M & Schumacher, U 2015, 'Lectin Histochemistry Shows WGA, PHA-L and HPA Binding Increases During Progression of Human Colorectal Cancer', ANTICANCER RES, vol. 35, no. 10, pp. 5333-9.

APA

Hägerbäumer, P., Vieth, M., Anders, M., & Schumacher, U. (2015). Lectin Histochemistry Shows WGA, PHA-L and HPA Binding Increases During Progression of Human Colorectal Cancer. ANTICANCER RES, 35(10), 5333-9.

Vancouver

Hägerbäumer P, Vieth M, Anders M, Schumacher U. Lectin Histochemistry Shows WGA, PHA-L and HPA Binding Increases During Progression of Human Colorectal Cancer. ANTICANCER RES. 2015 Oct;35(10):5333-9.

Bibtex

@article{4e7827026fd544ed9885e62905b22884,
title = "Lectin Histochemistry Shows WGA, PHA-L and HPA Binding Increases During Progression of Human Colorectal Cancer",
abstract = "BACKGROUND/AIM: Most colorectal carcinomas develop from an adenoma-carcinoma sequence to metastatic disease. The aim of the present study was to use lectins, carbohydrate-binding proteins, to detect changes in glycosylation during this malignant progression.MATERIALS AND METHODS: Sections from normal colorectal mucosa, high-grade intraepithelial neoplasia, submucosal colorectal carcinoma and metastases from patients who underwent colorectal surgery were stained by lectins with different sugar specificities namely agglutins from Wheatgerm (WGA), Helix pomatia (HPA), Phaseolus vulgaris (PHA-L), Ulex europaeus (UEA-I), Sambucus nigra (SNA-I), Canavalia ensiformis (Con A), Galanthus nivalis (GNA) and Dolichos biflorus (DBA).RESULTS: Binding patterns of all lectins except SNA-I, Con A and DBA changed during the adenoma-carcinoma sequence.CONCLUSION: The results indicate that lectins specific for mannose, N-acetylgalactosamine, N-acetylglucosamine, sialic acid, β-1,6-branched oligosaccharides and α-1-fucose may be associated with malignant progression.",
author = "Pia H{\"a}gerb{\"a}umer and Michael Vieth and Mario Anders and Udo Schumacher",
note = "Copyright{\textcopyright} 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.",
year = "2015",
month = oct,
language = "English",
volume = "35",
pages = "5333--9",
journal = "ANTICANCER RES",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "10",

}

RIS

TY - JOUR

T1 - Lectin Histochemistry Shows WGA, PHA-L and HPA Binding Increases During Progression of Human Colorectal Cancer

AU - Hägerbäumer, Pia

AU - Vieth, Michael

AU - Anders, Mario

AU - Schumacher, Udo

N1 - Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

PY - 2015/10

Y1 - 2015/10

N2 - BACKGROUND/AIM: Most colorectal carcinomas develop from an adenoma-carcinoma sequence to metastatic disease. The aim of the present study was to use lectins, carbohydrate-binding proteins, to detect changes in glycosylation during this malignant progression.MATERIALS AND METHODS: Sections from normal colorectal mucosa, high-grade intraepithelial neoplasia, submucosal colorectal carcinoma and metastases from patients who underwent colorectal surgery were stained by lectins with different sugar specificities namely agglutins from Wheatgerm (WGA), Helix pomatia (HPA), Phaseolus vulgaris (PHA-L), Ulex europaeus (UEA-I), Sambucus nigra (SNA-I), Canavalia ensiformis (Con A), Galanthus nivalis (GNA) and Dolichos biflorus (DBA).RESULTS: Binding patterns of all lectins except SNA-I, Con A and DBA changed during the adenoma-carcinoma sequence.CONCLUSION: The results indicate that lectins specific for mannose, N-acetylgalactosamine, N-acetylglucosamine, sialic acid, β-1,6-branched oligosaccharides and α-1-fucose may be associated with malignant progression.

AB - BACKGROUND/AIM: Most colorectal carcinomas develop from an adenoma-carcinoma sequence to metastatic disease. The aim of the present study was to use lectins, carbohydrate-binding proteins, to detect changes in glycosylation during this malignant progression.MATERIALS AND METHODS: Sections from normal colorectal mucosa, high-grade intraepithelial neoplasia, submucosal colorectal carcinoma and metastases from patients who underwent colorectal surgery were stained by lectins with different sugar specificities namely agglutins from Wheatgerm (WGA), Helix pomatia (HPA), Phaseolus vulgaris (PHA-L), Ulex europaeus (UEA-I), Sambucus nigra (SNA-I), Canavalia ensiformis (Con A), Galanthus nivalis (GNA) and Dolichos biflorus (DBA).RESULTS: Binding patterns of all lectins except SNA-I, Con A and DBA changed during the adenoma-carcinoma sequence.CONCLUSION: The results indicate that lectins specific for mannose, N-acetylgalactosamine, N-acetylglucosamine, sialic acid, β-1,6-branched oligosaccharides and α-1-fucose may be associated with malignant progression.

M3 - SCORING: Journal article

C2 - 26408694

VL - 35

SP - 5333

EP - 5339

JO - ANTICANCER RES

JF - ANTICANCER RES

SN - 0250-7005

IS - 10

ER -