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Lebensbedrohliche Komplikationen von Morbus Crohn und Colitis ulcerosa. Eine systematische Auswertung von Intensiv-Aufnahmen über 18 Jahre

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Lebensbedrohliche Komplikationen von Morbus Crohn und Colitis ulcerosa. Eine systematische Auswertung von Intensiv-Aufnahmen über 18 Jahre. / Huber, W; Herrmann, G; Schuster, T; Phillip, V; Saugel, B; Schultheiss, C; Hoellthaler, J; Gaa, J; Hartel, M; Schmid, R M; Reindl, W.

In: DEUT MED WOCHENSCHR, Vol. 135, No. 14, 01.04.2010, p. 668-74.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Huber, W, Herrmann, G, Schuster, T, Phillip, V, Saugel, B, Schultheiss, C, Hoellthaler, J, Gaa, J, Hartel, M, Schmid, RM & Reindl, W 2010, 'Lebensbedrohliche Komplikationen von Morbus Crohn und Colitis ulcerosa. Eine systematische Auswertung von Intensiv-Aufnahmen über 18 Jahre', DEUT MED WOCHENSCHR, vol. 135, no. 14, pp. 668-74. https://doi.org/10.1055/s-0030-1251915

APA

Huber, W., Herrmann, G., Schuster, T., Phillip, V., Saugel, B., Schultheiss, C., Hoellthaler, J., Gaa, J., Hartel, M., Schmid, R. M., & Reindl, W. (2010). Lebensbedrohliche Komplikationen von Morbus Crohn und Colitis ulcerosa. Eine systematische Auswertung von Intensiv-Aufnahmen über 18 Jahre. DEUT MED WOCHENSCHR, 135(14), 668-74. https://doi.org/10.1055/s-0030-1251915

Vancouver

Huber W, Herrmann G, Schuster T, Phillip V, Saugel B, Schultheiss C et al. Lebensbedrohliche Komplikationen von Morbus Crohn und Colitis ulcerosa. Eine systematische Auswertung von Intensiv-Aufnahmen über 18 Jahre. DEUT MED WOCHENSCHR. 2010 Apr 1;135(14):668-74. https://doi.org/10.1055/s-0030-1251915

Bibtex

@article{929e5d53602d411d84a342dfbbbcac6e,
title = "Lebensbedrohliche Komplikationen von Morbus Crohn und Colitis ulcerosa. Eine systematische Auswertung von Intensiv-Aufnahmen {\"u}ber 18 Jahre",
abstract = "BACKGROUND AND OBJECTIVE: Despite numerous publications on the epidemiology of inflammatory bowel diseases (IBD) there is a lack of systematic investigations on live-threatening complications of IBD and their causes. This study evaluates risk factors, course and outcome in intensive-care patients which were related to complications of IBD.PATIENTS AND METHODS: Among 6071 admissions to the intensive-care unit (ICU) of a gastroenterological department (university hospital with IBD-outpatient unit) between 1.1.1991 and 31.1.2008 36 ICU admissions of 28 patients with IBD were documented and prospectively analysed from 1996 onwards, using a structured questionnaire on causes for ICU admission as well as risk factors regarding death, organ failure and length of ICU stay.RESULTS: ICU admissions of IBD patients mainly resulted from three causes: complications specific to IBD (44 %), including acute flare-up, perforation and electrolyte imbalance, septic complications (22 %) and thromboembolic complications (17 %). Five patients died, all from septic complications related to immunosuppression including candida sepsis, varicella pneumonia during treatment with infliximab, and pneumocystis pneumonia related to treatment with azathioprine. The most important risk factors according to uni- and multivariate analyses were old age on ICU-admission and first diagnosis of IBD, previous surgery related to IBD and Crohn's disease.CONCLUSIONS: Complications of both IBD and immunosuppressive therapy may be live-threatening in patients with IBD. Better characterization of patients with a high probability of improved outcome by immunosuppressive and/or antibody-therapy seems to be preferable to noncritical early use of these drugs.",
keywords = "Adult, Aged, Cause of Death, Colitis, Ulcerative, Crohn Disease, Female, Germany, Hospital Mortality, Hospitals, University, Humans, Intensive Care Units, Length of Stay, Male, Middle Aged, Prognosis, Recurrence, Retrospective Studies, Risk Factors, Treatment Outcome, Young Adult",
author = "W Huber and G Herrmann and T Schuster and V Phillip and B Saugel and C Schultheiss and J Hoellthaler and J Gaa and M Hartel and Schmid, {R M} and W Reindl",
note = "Georg Thieme Verlag KG Stuttgart, New York.",
year = "2010",
month = apr,
day = "1",
doi = "10.1055/s-0030-1251915",
language = "Deutsch",
volume = "135",
pages = "668--74",
journal = "DEUT MED WOCHENSCHR",
issn = "0012-0472",
publisher = "Georg Thieme Verlag KG",
number = "14",

}

RIS

TY - JOUR

T1 - Lebensbedrohliche Komplikationen von Morbus Crohn und Colitis ulcerosa. Eine systematische Auswertung von Intensiv-Aufnahmen über 18 Jahre

AU - Huber, W

AU - Herrmann, G

AU - Schuster, T

AU - Phillip, V

AU - Saugel, B

AU - Schultheiss, C

AU - Hoellthaler, J

AU - Gaa, J

AU - Hartel, M

AU - Schmid, R M

AU - Reindl, W

N1 - Georg Thieme Verlag KG Stuttgart, New York.

PY - 2010/4/1

Y1 - 2010/4/1

N2 - BACKGROUND AND OBJECTIVE: Despite numerous publications on the epidemiology of inflammatory bowel diseases (IBD) there is a lack of systematic investigations on live-threatening complications of IBD and their causes. This study evaluates risk factors, course and outcome in intensive-care patients which were related to complications of IBD.PATIENTS AND METHODS: Among 6071 admissions to the intensive-care unit (ICU) of a gastroenterological department (university hospital with IBD-outpatient unit) between 1.1.1991 and 31.1.2008 36 ICU admissions of 28 patients with IBD were documented and prospectively analysed from 1996 onwards, using a structured questionnaire on causes for ICU admission as well as risk factors regarding death, organ failure and length of ICU stay.RESULTS: ICU admissions of IBD patients mainly resulted from three causes: complications specific to IBD (44 %), including acute flare-up, perforation and electrolyte imbalance, septic complications (22 %) and thromboembolic complications (17 %). Five patients died, all from septic complications related to immunosuppression including candida sepsis, varicella pneumonia during treatment with infliximab, and pneumocystis pneumonia related to treatment with azathioprine. The most important risk factors according to uni- and multivariate analyses were old age on ICU-admission and first diagnosis of IBD, previous surgery related to IBD and Crohn's disease.CONCLUSIONS: Complications of both IBD and immunosuppressive therapy may be live-threatening in patients with IBD. Better characterization of patients with a high probability of improved outcome by immunosuppressive and/or antibody-therapy seems to be preferable to noncritical early use of these drugs.

AB - BACKGROUND AND OBJECTIVE: Despite numerous publications on the epidemiology of inflammatory bowel diseases (IBD) there is a lack of systematic investigations on live-threatening complications of IBD and their causes. This study evaluates risk factors, course and outcome in intensive-care patients which were related to complications of IBD.PATIENTS AND METHODS: Among 6071 admissions to the intensive-care unit (ICU) of a gastroenterological department (university hospital with IBD-outpatient unit) between 1.1.1991 and 31.1.2008 36 ICU admissions of 28 patients with IBD were documented and prospectively analysed from 1996 onwards, using a structured questionnaire on causes for ICU admission as well as risk factors regarding death, organ failure and length of ICU stay.RESULTS: ICU admissions of IBD patients mainly resulted from three causes: complications specific to IBD (44 %), including acute flare-up, perforation and electrolyte imbalance, septic complications (22 %) and thromboembolic complications (17 %). Five patients died, all from septic complications related to immunosuppression including candida sepsis, varicella pneumonia during treatment with infliximab, and pneumocystis pneumonia related to treatment with azathioprine. The most important risk factors according to uni- and multivariate analyses were old age on ICU-admission and first diagnosis of IBD, previous surgery related to IBD and Crohn's disease.CONCLUSIONS: Complications of both IBD and immunosuppressive therapy may be live-threatening in patients with IBD. Better characterization of patients with a high probability of improved outcome by immunosuppressive and/or antibody-therapy seems to be preferable to noncritical early use of these drugs.

KW - Adult

KW - Aged

KW - Cause of Death

KW - Colitis, Ulcerative

KW - Crohn Disease

KW - Female

KW - Germany

KW - Hospital Mortality

KW - Hospitals, University

KW - Humans

KW - Intensive Care Units

KW - Length of Stay

KW - Male

KW - Middle Aged

KW - Prognosis

KW - Recurrence

KW - Retrospective Studies

KW - Risk Factors

KW - Treatment Outcome

KW - Young Adult

U2 - 10.1055/s-0030-1251915

DO - 10.1055/s-0030-1251915

M3 - SCORING: Zeitschriftenaufsatz

C2 - 20358493

VL - 135

SP - 668

EP - 674

JO - DEUT MED WOCHENSCHR

JF - DEUT MED WOCHENSCHR

SN - 0012-0472

IS - 14

ER -