Research ExplorerPublicationsL-Arginine Derivatives Are Associated with the Hyperthyroid ...

L-Arginine Derivatives Are Associated with the Hyperthyroid State in the General Population

Standard

L-Arginine Derivatives Are Associated with the Hyperthyroid State in the General Population. / Ittermann, Till; Bahls, Martin; Atzler, Dorothee; Friedrich, Nele; Schwedhelm, Edzard; Böger, Rainer H; Felix, Stephan B; Völzke, Henry; Dörr, Marcus.

In: THYROID, Vol. 26, No. 2, 02.2016, p. 212-8.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Ittermann, T, Bahls, M, Atzler, D, Friedrich, N, Schwedhelm, E, Böger, RH, Felix, SB, Völzke, H & Dörr, M 2016, 'L-Arginine Derivatives Are Associated with the Hyperthyroid State in the General Population', THYROID, vol. 26, no. 2, pp. 212-8. https://doi.org/10.1089/thy.2015.0385

APA

Ittermann, T., Bahls, M., Atzler, D., Friedrich, N., Schwedhelm, E., Böger, R. H., Felix, S. B., Völzke, H., & Dörr, M. (2016). L-Arginine Derivatives Are Associated with the Hyperthyroid State in the General Population. THYROID, 26(2), 212-8. https://doi.org/10.1089/thy.2015.0385

Vancouver

Ittermann T, Bahls M, Atzler D, Friedrich N, Schwedhelm E, Böger RH et al. L-Arginine Derivatives Are Associated with the Hyperthyroid State in the General Population. THYROID. 2016 Feb;26(2):212-8. https://doi.org/10.1089/thy.2015.0385

Bibtex

@article{bec2df94824e4311bdc9663d06f5df03,
title = "L-Arginine Derivatives Are Associated with the Hyperthyroid State in the General Population",
abstract = "BACKGROUND: Arginine (ARG) derivatives and thyroid function independently influence atherosclerotic processes. Since thyroid hormones may mediate the association between ARG derivatives and atherosclerosis, this study investigated whether asymmetric and symmetric dimethylarginines (ADMA and SDMA, respectively) as well as homoarginine (hARG) are associated with parameters of thyroid function in the general population.METHODS: Cross-sectional data from 3689 individuals aged 20-81 years from the population-based Study of Health in Pomerania (SHIP-0) were analyzed. Thyroid function was defined according to serum concentrations of thyrotropin (TSH), free triiodothyronine (fT3), and free thyroxine (fT4). Low and high serum TSH were defined by the cutoffs 0.3 mIU/L and 3 mIU/L, respectively. Serum concentrations of ARG, ADMA, SDMA, and hARG were measured using liquid chromatography-tandem mass spectrometry. ARG, ADMA, SDMA, and hARG were associated with serum concentrations of TSH, fT3, and fT4 by median regression and with categorized TSH values by multinomial logistic regression adjusted for age, sex, smoking status, physical activity, body mass index, and estimated glomerular filtration rate.RESULTS: Levels of ADMA (relative risk [RR] = 5.40 [confidence interval (CI) 1.96-14.86]) and SDMA (RR = 3.55 [CI 1.01-12.70]) were associated with low TSH. In addition, ADMA (β = 0.38 [CI 0.23-0.45]) was positively associated with fT3, while both ADMA (β = 0.98 [CI 0.43-1.54]) and SDMA (β = 1.19 [CI 0.50-1.88]) were positively associated with fT4. No consistent associations of ARG and hARG with thyroid function were detected.CONCLUSIONS: The positive associations of ADMA and SDMA with low TSH, fT3, and fT4 argue for a relationship of arginine derivatives with increased thyroid function. This suggests that the atherogenic properties of ADMA and SDMA may be partially mediated by thyroid function.",
author = "Till Ittermann and Martin Bahls and Dorothee Atzler and Nele Friedrich and Edzard Schwedhelm and B{\"o}ger, {Rainer H} and Felix, {Stephan B} and Henry V{\"o}lzke and Marcus D{\"o}rr",
year = "2016",
month = feb,
doi = "10.1089/thy.2015.0385",
language = "English",
volume = "26",
pages = "212--8",
journal = "THYROID",
issn = "1050-7256",
publisher = "Mary Ann Liebert Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - L-Arginine Derivatives Are Associated with the Hyperthyroid State in the General Population

AU - Ittermann, Till

AU - Bahls, Martin

AU - Atzler, Dorothee

AU - Friedrich, Nele

AU - Schwedhelm, Edzard

AU - Böger, Rainer H

AU - Felix, Stephan B

AU - Völzke, Henry

AU - Dörr, Marcus

PY - 2016/2

Y1 - 2016/2

N2 - BACKGROUND: Arginine (ARG) derivatives and thyroid function independently influence atherosclerotic processes. Since thyroid hormones may mediate the association between ARG derivatives and atherosclerosis, this study investigated whether asymmetric and symmetric dimethylarginines (ADMA and SDMA, respectively) as well as homoarginine (hARG) are associated with parameters of thyroid function in the general population.METHODS: Cross-sectional data from 3689 individuals aged 20-81 years from the population-based Study of Health in Pomerania (SHIP-0) were analyzed. Thyroid function was defined according to serum concentrations of thyrotropin (TSH), free triiodothyronine (fT3), and free thyroxine (fT4). Low and high serum TSH were defined by the cutoffs 0.3 mIU/L and 3 mIU/L, respectively. Serum concentrations of ARG, ADMA, SDMA, and hARG were measured using liquid chromatography-tandem mass spectrometry. ARG, ADMA, SDMA, and hARG were associated with serum concentrations of TSH, fT3, and fT4 by median regression and with categorized TSH values by multinomial logistic regression adjusted for age, sex, smoking status, physical activity, body mass index, and estimated glomerular filtration rate.RESULTS: Levels of ADMA (relative risk [RR] = 5.40 [confidence interval (CI) 1.96-14.86]) and SDMA (RR = 3.55 [CI 1.01-12.70]) were associated with low TSH. In addition, ADMA (β = 0.38 [CI 0.23-0.45]) was positively associated with fT3, while both ADMA (β = 0.98 [CI 0.43-1.54]) and SDMA (β = 1.19 [CI 0.50-1.88]) were positively associated with fT4. No consistent associations of ARG and hARG with thyroid function were detected.CONCLUSIONS: The positive associations of ADMA and SDMA with low TSH, fT3, and fT4 argue for a relationship of arginine derivatives with increased thyroid function. This suggests that the atherogenic properties of ADMA and SDMA may be partially mediated by thyroid function.

AB - BACKGROUND: Arginine (ARG) derivatives and thyroid function independently influence atherosclerotic processes. Since thyroid hormones may mediate the association between ARG derivatives and atherosclerosis, this study investigated whether asymmetric and symmetric dimethylarginines (ADMA and SDMA, respectively) as well as homoarginine (hARG) are associated with parameters of thyroid function in the general population.METHODS: Cross-sectional data from 3689 individuals aged 20-81 years from the population-based Study of Health in Pomerania (SHIP-0) were analyzed. Thyroid function was defined according to serum concentrations of thyrotropin (TSH), free triiodothyronine (fT3), and free thyroxine (fT4). Low and high serum TSH were defined by the cutoffs 0.3 mIU/L and 3 mIU/L, respectively. Serum concentrations of ARG, ADMA, SDMA, and hARG were measured using liquid chromatography-tandem mass spectrometry. ARG, ADMA, SDMA, and hARG were associated with serum concentrations of TSH, fT3, and fT4 by median regression and with categorized TSH values by multinomial logistic regression adjusted for age, sex, smoking status, physical activity, body mass index, and estimated glomerular filtration rate.RESULTS: Levels of ADMA (relative risk [RR] = 5.40 [confidence interval (CI) 1.96-14.86]) and SDMA (RR = 3.55 [CI 1.01-12.70]) were associated with low TSH. In addition, ADMA (β = 0.38 [CI 0.23-0.45]) was positively associated with fT3, while both ADMA (β = 0.98 [CI 0.43-1.54]) and SDMA (β = 1.19 [CI 0.50-1.88]) were positively associated with fT4. No consistent associations of ARG and hARG with thyroid function were detected.CONCLUSIONS: The positive associations of ADMA and SDMA with low TSH, fT3, and fT4 argue for a relationship of arginine derivatives with increased thyroid function. This suggests that the atherogenic properties of ADMA and SDMA may be partially mediated by thyroid function.

U2 - 10.1089/thy.2015.0385

DO - 10.1089/thy.2015.0385

M3 - SCORING: Journal article

C2 - 26650143

VL - 26

SP - 212

EP - 218

JO - THYROID

JF - THYROID

SN - 1050-7256

IS - 2

ER -