Large-scale dynamics of perceptual decision information across human cortex
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Large-scale dynamics of perceptual decision information across human cortex. / Wilming, Niklas; Murphy, Peter R; Meyniel, Florent; Donner, Tobias H.
In: NAT COMMUN, Vol. 11, No. 1, 09.10.2020, p. 5109.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Large-scale dynamics of perceptual decision information across human cortex
AU - Wilming, Niklas
AU - Murphy, Peter R
AU - Meyniel, Florent
AU - Donner, Tobias H
PY - 2020/10/9
Y1 - 2020/10/9
N2 - Perceptual decisions entail the accumulation of sensory evidence for a particular choice towards an action plan. An influential framework holds that sensory cortical areas encode the instantaneous sensory evidence and downstream, action-related regions accumulate this evidence. The large-scale distribution of this computation across the cerebral cortex has remained largely elusive. Here, we develop a regionally-specific magnetoencephalography decoding approach to exhaustively map the dynamics of stimulus- and choice-specific signals across the human cortical surface during a visual decision. Comparison with the evidence accumulation dynamics inferred from behavior disentangles stimulus-dependent and endogenous components of choice-predictive activity across the visual cortical hierarchy. We find such an endogenous component in early visual cortex (including V1), which is expressed in a low (<20 Hz) frequency band and tracks, with delay, the build-up of choice-predictive activity in (pre-) motor regions. Our results are consistent with choice- and frequency-specific cortical feedback signaling during decision formation.
AB - Perceptual decisions entail the accumulation of sensory evidence for a particular choice towards an action plan. An influential framework holds that sensory cortical areas encode the instantaneous sensory evidence and downstream, action-related regions accumulate this evidence. The large-scale distribution of this computation across the cerebral cortex has remained largely elusive. Here, we develop a regionally-specific magnetoencephalography decoding approach to exhaustively map the dynamics of stimulus- and choice-specific signals across the human cortical surface during a visual decision. Comparison with the evidence accumulation dynamics inferred from behavior disentangles stimulus-dependent and endogenous components of choice-predictive activity across the visual cortical hierarchy. We find such an endogenous component in early visual cortex (including V1), which is expressed in a low (<20 Hz) frequency band and tracks, with delay, the build-up of choice-predictive activity in (pre-) motor regions. Our results are consistent with choice- and frequency-specific cortical feedback signaling during decision formation.
KW - Cerebral Cortex/physiology
KW - Choice Behavior
KW - Decision Making
KW - Female
KW - Humans
KW - Magnetoencephalography/methods
KW - Male
KW - Nontherapeutic Human Experimentation
KW - Signal Processing, Computer-Assisted
KW - Visual Cortex/physiology
KW - Visual Perception/physiology
U2 - 10.1038/s41467-020-18826-6
DO - 10.1038/s41467-020-18826-6
M3 - SCORING: Journal article
C2 - 33037209
VL - 11
SP - 5109
JO - NAT COMMUN
JF - NAT COMMUN
SN - 2041-1723
IS - 1
ER -