Research ExplorerPublicationsLarge-scale association analysis identifies new risk loci fo...

Large-scale association analysis identifies new risk loci for coronary artery disease

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Large-scale association analysis identifies new risk loci for coronary artery disease. / Deloukas, Panos; Kanoni, Stavroula; Willenborg, Christina; Farrall, Martin; Assimes, Themistocles L; Thompson, John R; Ingelsson, Erik; Saleheen, Danish; Erdmann, Jeanette; Goldstein, Benjamin A; Stirrups, Kathleen; König, Inke R; Cazier, Jean-Baptiste; Johansson, Asa; Hall, Alistair S; Lee, Jong-Young; Willer, Cristen J; Chambers, John C; Esko, Tõnu; Folkersen, Lasse; Goel, Anuj; Grundberg, Elin; Havulinna, Aki S; Ho, Weang K; Hopewell, Jemma C; Eriksson, Niclas; Kleber, Marcus E; Kristiansson, Kati; Lundmark, Per; Lyytikäinen, Leo-Pekka; Rafelt, Suzanne; Shungin, Dmitry; Strawbridge, Rona J; Thorleifsson, Gudmar; Tikkanen, Emmi; Van Zuydam, Natalie; Voight, Benjamin F; Waite, Lindsay L; Zhang, Weihua; Ziegler, Andreas; Absher, Devin; Altshuler, David; Balmforth, Anthony J; Barroso, Inês; Braund, Peter S; Burgdorf, Christof; Claudi-Boehm, Simone; Cox, David; Dimitriou, Maria; Do, Ron; Doney, Alex S F; El Mokhtari, NourEddine; Eriksson, Per; Fischer, Krista; Fontanillas, Pierre; Franco-Cereceda, Anders; Gigante, Bruna; Groop, Leif; Gustafsson, Stefan; Hager, Jörg; Hallmans, Göran; Han, Bok-Ghee; Hunt, Sarah E; Kang, Hyun M; Illig, Thomas; Kessler, Thorsten; Knowles, Joshua W; Kolovou, Genovefa; Kuusisto, Johanna; Langenberg, Claudia; Langford, Cordelia; Leander, Karin; Lokki, Marja-Liisa; Lundmark, Anders; McCarthy, Mark I; Meisinger, Christa; Melander, Olle; Mihailov, Evelin; Maouche, Seraya; Morris, Andrew D; Müller-Nurasyid, Martina; Nikus, Kjell; Peden, John F; Rayner, N William; Rasheed, Asif; Rosinger, Silke; Rubin, Diana; Rumpf, Moritz P; Schäfer, Arne; Sivananthan, Mohan; Song, Ci; Stewart, Alexandre F R; Tan, Sian-Tsung; Thorgeirsson, Gudmundur; van der Schoot, C Ellen; Wagner, Peter J; Wells, George A; Wild, Philipp S; Yang, Tsun-Po; Amouyel, Philippe; Arveiler, Dominique; Basart, Hanneke; Boehnke, Michael; Boerwinkle, Eric; Brambilla, Paolo; Cambien, Francois; Cupples, Adrienne L; de Faire, Ulf; Dehghan, Abbas; Diemert, Patrick; Epstein, Stephen E; Evans, Alun; Ferrario, Marco M; Ferrières, Jean; Gauguier, Dominique; Go, Alan S; Goodall, Alison H; Gudnason, Villi; Hazen, Stanley L; Holm, Hilma; Iribarren, Carlos; Jang, Yangsoo; Kähönen, Mika; Kee, Frank; Kim, Hyo-Soo; Klopp, Norman; Koenig, Wolfgang; Kratzer, Wolfgang; Kuulasmaa, Kari; Laakso, Markku; Laaksonen, Reijo; Lee, Ji-Young; Lind, Lars; Ouwehand, Willem H; Parish, Sarah; Park, Jeong E; Pedersen, Nancy L; Peters, Annette; Quertermous, Thomas; Rader, Daniel J; Salomaa, Veikko; Schadt, Eric; Shah, Svati H; Sinisalo, Juha; Stark, Klaus; Stefansson, Kari; Trégouët, David-Alexandre; Virtamo, Jarmo; Wallentin, Lars; Wareham, Nicholas; Zimmermann, Martina E; Nieminen, Markku S; Hengstenberg, Christian; Sandhu, Manjinder S; Pastinen, Tomi; Syvänen, Ann-Christine; Hovingh, G Kees; Dedoussis, George; Franks, Paul W; Lehtimäki, Terho; Metspalu, Andres; Zalloua, Pierre A; Siegbahn, Agneta; Schreiber, Stefan; Ripatti, Samuli; Blankenberg, Stefan S; Perola, Markus; Clarke, Robert; Boehm, Bernhard O; O'Donnell, Christopher; Reilly, Muredach P; März, Winfried; Collins, Rory; Kathiresan, Sekar; Hamsten, Anders; Kooner, Jaspal S; Thorsteinsdottir, Unnur; Danesh, John; Palmer, Colin N A; Roberts, Robert; Watkins, Hugh; Schunkert, Heribert; Samani, Nilesh J; CARDIoGRAMplusC4D Consortium.

In: NAT GENET, Vol. 45, No. 1, 01.2013, p. 25-33.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Deloukas, P, Kanoni, S, Willenborg, C, Farrall, M, Assimes, TL, Thompson, JR, Ingelsson, E, Saleheen, D, Erdmann, J, Goldstein, BA, Stirrups, K, König, IR, Cazier, J-B, Johansson, A, Hall, AS, Lee, J-Y, Willer, CJ, Chambers, JC, Esko, T, Folkersen, L, Goel, A, Grundberg, E, Havulinna, AS, Ho, WK, Hopewell, JC, Eriksson, N, Kleber, ME, Kristiansson, K, Lundmark, P, Lyytikäinen, L-P, Rafelt, S, Shungin, D, Strawbridge, RJ, Thorleifsson, G, Tikkanen, E, Van Zuydam, N, Voight, BF, Waite, LL, Zhang, W, Ziegler, A, Absher, D, Altshuler, D, Balmforth, AJ, Barroso, I, Braund, PS, Burgdorf, C, Claudi-Boehm, S, Cox, D, Dimitriou, M, Do, R, Doney, ASF, El Mokhtari, N, Eriksson, P, Fischer, K, Fontanillas, P, Franco-Cereceda, A, Gigante, B, Groop, L, Gustafsson, S, Hager, J, Hallmans, G, Han, B-G, Hunt, SE, Kang, HM, Illig, T, Kessler, T, Knowles, JW, Kolovou, G, Kuusisto, J, Langenberg, C, Langford, C, Leander, K, Lokki, M-L, Lundmark, A, McCarthy, MI, Meisinger, C, Melander, O, Mihailov, E, Maouche, S, Morris, AD, Müller-Nurasyid, M, Nikus, K, Peden, JF, Rayner, NW, Rasheed, A, Rosinger, S, Rubin, D, Rumpf, MP, Schäfer, A, Sivananthan, M, Song, C, Stewart, AFR, Tan, S-T, Thorgeirsson, G, van der Schoot, CE, Wagner, PJ, Wells, GA, Wild, PS, Yang, T-P, Amouyel, P, Arveiler, D, Basart, H, Boehnke, M, Boerwinkle, E, Brambilla, P, Cambien, F, Cupples, AL, de Faire, U, Dehghan, A, Diemert, P, Epstein, SE, Evans, A, Ferrario, MM, Ferrières, J, Gauguier, D, Go, AS, Goodall, AH, Gudnason, V, Hazen, SL, Holm, H, Iribarren, C, Jang, Y, Kähönen, M, Kee, F, Kim, H-S, Klopp, N, Koenig, W, Kratzer, W, Kuulasmaa, K, Laakso, M, Laaksonen, R, Lee, J-Y, Lind, L, Ouwehand, WH, Parish, S, Park, JE, Pedersen, NL, Peters, A, Quertermous, T, Rader, DJ, Salomaa, V, Schadt, E, Shah, SH, Sinisalo, J, Stark, K, Stefansson, K, Trégouët, D-A, Virtamo, J, Wallentin, L, Wareham, N, Zimmermann, ME, Nieminen, MS, Hengstenberg, C, Sandhu, MS, Pastinen, T, Syvänen, A-C, Hovingh, GK, Dedoussis, G, Franks, PW, Lehtimäki, T, Metspalu, A, Zalloua, PA, Siegbahn, A, Schreiber, S, Ripatti, S, Blankenberg, SS, Perola, M, Clarke, R, Boehm, BO, O'Donnell, C, Reilly, MP, März, W, Collins, R, Kathiresan, S, Hamsten, A, Kooner, JS, Thorsteinsdottir, U, Danesh, J, Palmer, CNA, Roberts, R, Watkins, H, Schunkert, H, Samani, NJ & CARDIoGRAMplusC4D Consortium 2013, 'Large-scale association analysis identifies new risk loci for coronary artery disease', NAT GENET, vol. 45, no. 1, pp. 25-33. https://doi.org/10.1038/ng.2480

APA

Deloukas, P., Kanoni, S., Willenborg, C., Farrall, M., Assimes, T. L., Thompson, J. R., Ingelsson, E., Saleheen, D., Erdmann, J., Goldstein, B. A., Stirrups, K., König, I. R., Cazier, J-B., Johansson, A., Hall, A. S., Lee, J-Y., Willer, C. J., Chambers, J. C., Esko, T., ... CARDIoGRAMplusC4D Consortium (2013). Large-scale association analysis identifies new risk loci for coronary artery disease. NAT GENET, 45(1), 25-33. https://doi.org/10.1038/ng.2480

Vancouver

Deloukas P, Kanoni S, Willenborg C, Farrall M, Assimes TL, Thompson JR et al. Large-scale association analysis identifies new risk loci for coronary artery disease. NAT GENET. 2013 Jan;45(1):25-33. https://doi.org/10.1038/ng.2480

Bibtex

@article{5db942872ed04fa79c053c792fcdb485,
title = "Large-scale association analysis identifies new risk loci for coronary artery disease",
abstract = "Coronary artery disease (CAD) is the commonest cause of death. Here, we report an association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching genome-wide significance, taking the number of susceptibility loci for CAD to 46, and a further 104 independent variants (r(2) < 0.2) strongly associated with CAD at a 5% false discovery rate (FDR). Together, these variants explain approximately 10.6% of CAD heritability. Of the 46 genome-wide significant lead SNPs, 12 show a significant association with a lipid trait, and 5 show a significant association with blood pressure, but none is significantly associated with diabetes. Network analysis with 233 candidate genes (loci at 10% FDR) generated 5 interaction networks comprising 85% of these putative genes involved in CAD. The four most significant pathways mapping to these networks are linked to lipid metabolism and inflammation, underscoring the causal role of these activities in the genetic etiology of CAD. Our study provides insights into the genetic basis of CAD and identifies key biological pathways.",
keywords = "Adult, Aged, Asian Continental Ancestry Group, Cell Line, Coronary Artery Disease/genetics, European Continental Ancestry Group/genetics, Female, Gene Regulatory Networks, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Risk Factors",
author = "Panos Deloukas and Stavroula Kanoni and Christina Willenborg and Martin Farrall and Assimes, {Themistocles L} and Thompson, {John R} and Erik Ingelsson and Danish Saleheen and Jeanette Erdmann and Goldstein, {Benjamin A} and Kathleen Stirrups and K{\"o}nig, {Inke R} and Jean-Baptiste Cazier and Asa Johansson and Hall, {Alistair S} and Jong-Young Lee and Willer, {Cristen J} and Chambers, {John C} and T{\~o}nu Esko and Lasse Folkersen and Anuj Goel and Elin Grundberg and Havulinna, {Aki S} and Ho, {Weang K} and Hopewell, {Jemma C} and Niclas Eriksson and Kleber, {Marcus E} and Kati Kristiansson and Per Lundmark and Leo-Pekka Lyytik{\"a}inen and Suzanne Rafelt and Dmitry Shungin and Strawbridge, {Rona J} and Gudmar Thorleifsson and Emmi Tikkanen and {Van Zuydam}, Natalie and Voight, {Benjamin F} and Waite, {Lindsay L} and Weihua Zhang and Andreas Ziegler and Devin Absher and David Altshuler and Balmforth, {Anthony J} and In{\^e}s Barroso and Braund, {Peter S} and Christof Burgdorf and Simone Claudi-Boehm and David Cox and Maria Dimitriou and Ron Do and Doney, {Alex S F} and {El Mokhtari}, NourEddine and Per Eriksson and Krista Fischer and Pierre Fontanillas and Anders Franco-Cereceda and Bruna Gigante and Leif Groop and Stefan Gustafsson and J{\"o}rg Hager and G{\"o}ran Hallmans and Bok-Ghee Han and Hunt, {Sarah E} and Kang, {Hyun M} and Thomas Illig and Thorsten Kessler and Knowles, {Joshua W} and Genovefa Kolovou and Johanna Kuusisto and Claudia Langenberg and Cordelia Langford and Karin Leander and Marja-Liisa Lokki and Anders Lundmark and McCarthy, {Mark I} and Christa Meisinger and Olle Melander and Evelin Mihailov and Seraya Maouche and Morris, {Andrew D} and Martina M{\"u}ller-Nurasyid and Kjell Nikus and Peden, {John F} and Rayner, {N William} and Asif Rasheed and Silke Rosinger and Diana Rubin and Rumpf, {Moritz P} and Arne Sch{\"a}fer and Mohan Sivananthan and Ci Song and Stewart, {Alexandre F R} and Sian-Tsung Tan and Gudmundur Thorgeirsson and {van der Schoot}, {C Ellen} and Wagner, {Peter J} and Wells, {George A} and Wild, {Philipp S} and Tsun-Po Yang and Philippe Amouyel and Dominique Arveiler and Hanneke Basart and Michael Boehnke and Eric Boerwinkle and Paolo Brambilla and Francois Cambien and Cupples, {Adrienne L} and {de Faire}, Ulf and Abbas Dehghan and Patrick Diemert and Epstein, {Stephen E} and Alun Evans and Ferrario, {Marco M} and Jean Ferri{\`e}res and Dominique Gauguier and Go, {Alan S} and Goodall, {Alison H} and Villi Gudnason and Hazen, {Stanley L} and Hilma Holm and Carlos Iribarren and Yangsoo Jang and Mika K{\"a}h{\"o}nen and Frank Kee and Hyo-Soo Kim and Norman Klopp and Wolfgang Koenig and Wolfgang Kratzer and Kari Kuulasmaa and Markku Laakso and Reijo Laaksonen and Ji-Young Lee and Lars Lind and Ouwehand, {Willem H} and Sarah Parish and Park, {Jeong E} and Pedersen, {Nancy L} and Annette Peters and Thomas Quertermous and Rader, {Daniel J} and Veikko Salomaa and Eric Schadt and Shah, {Svati H} and Juha Sinisalo and Klaus Stark and Kari Stefansson and David-Alexandre Tr{\'e}gou{\"e}t and Jarmo Virtamo and Lars Wallentin and Nicholas Wareham and Zimmermann, {Martina E} and Nieminen, {Markku S} and Christian Hengstenberg and Sandhu, {Manjinder S} and Tomi Pastinen and Ann-Christine Syv{\"a}nen and Hovingh, {G Kees} and George Dedoussis and Franks, {Paul W} and Terho Lehtim{\"a}ki and Andres Metspalu and Zalloua, {Pierre A} and Agneta Siegbahn and Stefan Schreiber and Samuli Ripatti and Blankenberg, {Stefan S} and Markus Perola and Robert Clarke and Boehm, {Bernhard O} and Christopher O'Donnell and Reilly, {Muredach P} and Winfried M{\"a}rz and Rory Collins and Sekar Kathiresan and Anders Hamsten and Kooner, {Jaspal S} and Unnur Thorsteinsdottir and John Danesh and Palmer, {Colin N A} and Robert Roberts and Hugh Watkins and Heribert Schunkert and Samani, {Nilesh J} and {CARDIoGRAMplusC4D Consortium}",
year = "2013",
month = jan,
doi = "10.1038/ng.2480",
language = "English",
volume = "45",
pages = "25--33",
journal = "NAT GENET",
issn = "1061-4036",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - Large-scale association analysis identifies new risk loci for coronary artery disease

AU - Deloukas, Panos

AU - Kanoni, Stavroula

AU - Willenborg, Christina

AU - Farrall, Martin

AU - Assimes, Themistocles L

AU - Thompson, John R

AU - Ingelsson, Erik

AU - Saleheen, Danish

AU - Erdmann, Jeanette

AU - Goldstein, Benjamin A

AU - Stirrups, Kathleen

AU - König, Inke R

AU - Cazier, Jean-Baptiste

AU - Johansson, Asa

AU - Hall, Alistair S

AU - Lee, Jong-Young

AU - Willer, Cristen J

AU - Chambers, John C

AU - Esko, Tõnu

AU - Folkersen, Lasse

AU - Goel, Anuj

AU - Grundberg, Elin

AU - Havulinna, Aki S

AU - Ho, Weang K

AU - Hopewell, Jemma C

AU - Eriksson, Niclas

AU - Kleber, Marcus E

AU - Kristiansson, Kati

AU - Lundmark, Per

AU - Lyytikäinen, Leo-Pekka

AU - Rafelt, Suzanne

AU - Shungin, Dmitry

AU - Strawbridge, Rona J

AU - Thorleifsson, Gudmar

AU - Tikkanen, Emmi

AU - Van Zuydam, Natalie

AU - Voight, Benjamin F

AU - Waite, Lindsay L

AU - Zhang, Weihua

AU - Ziegler, Andreas

AU - Absher, Devin

AU - Altshuler, David

AU - Balmforth, Anthony J

AU - Barroso, Inês

AU - Braund, Peter S

AU - Burgdorf, Christof

AU - Claudi-Boehm, Simone

AU - Cox, David

AU - Dimitriou, Maria

AU - Do, Ron

AU - Doney, Alex S F

AU - El Mokhtari, NourEddine

AU - Eriksson, Per

AU - Fischer, Krista

AU - Fontanillas, Pierre

AU - Franco-Cereceda, Anders

AU - Gigante, Bruna

AU - Groop, Leif

AU - Gustafsson, Stefan

AU - Hager, Jörg

AU - Hallmans, Göran

AU - Han, Bok-Ghee

AU - Hunt, Sarah E

AU - Kang, Hyun M

AU - Illig, Thomas

AU - Kessler, Thorsten

AU - Knowles, Joshua W

AU - Kolovou, Genovefa

AU - Kuusisto, Johanna

AU - Langenberg, Claudia

AU - Langford, Cordelia

AU - Leander, Karin

AU - Lokki, Marja-Liisa

AU - Lundmark, Anders

AU - McCarthy, Mark I

AU - Meisinger, Christa

AU - Melander, Olle

AU - Mihailov, Evelin

AU - Maouche, Seraya

AU - Morris, Andrew D

AU - Müller-Nurasyid, Martina

AU - Nikus, Kjell

AU - Peden, John F

AU - Rayner, N William

AU - Rasheed, Asif

AU - Rosinger, Silke

AU - Rubin, Diana

AU - Rumpf, Moritz P

AU - Schäfer, Arne

AU - Sivananthan, Mohan

AU - Song, Ci

AU - Stewart, Alexandre F R

AU - Tan, Sian-Tsung

AU - Thorgeirsson, Gudmundur

AU - van der Schoot, C Ellen

AU - Wagner, Peter J

AU - Wells, George A

AU - Wild, Philipp S

AU - Yang, Tsun-Po

AU - Amouyel, Philippe

AU - Arveiler, Dominique

AU - Basart, Hanneke

AU - Boehnke, Michael

AU - Boerwinkle, Eric

AU - Brambilla, Paolo

AU - Cambien, Francois

AU - Cupples, Adrienne L

AU - de Faire, Ulf

AU - Dehghan, Abbas

AU - Diemert, Patrick

AU - Epstein, Stephen E

AU - Evans, Alun

AU - Ferrario, Marco M

AU - Ferrières, Jean

AU - Gauguier, Dominique

AU - Go, Alan S

AU - Goodall, Alison H

AU - Gudnason, Villi

AU - Hazen, Stanley L

AU - Holm, Hilma

AU - Iribarren, Carlos

AU - Jang, Yangsoo

AU - Kähönen, Mika

AU - Kee, Frank

AU - Kim, Hyo-Soo

AU - Klopp, Norman

AU - Koenig, Wolfgang

AU - Kratzer, Wolfgang

AU - Kuulasmaa, Kari

AU - Laakso, Markku

AU - Laaksonen, Reijo

AU - Lee, Ji-Young

AU - Lind, Lars

AU - Ouwehand, Willem H

AU - Parish, Sarah

AU - Park, Jeong E

AU - Pedersen, Nancy L

AU - Peters, Annette

AU - Quertermous, Thomas

AU - Rader, Daniel J

AU - Salomaa, Veikko

AU - Schadt, Eric

AU - Shah, Svati H

AU - Sinisalo, Juha

AU - Stark, Klaus

AU - Stefansson, Kari

AU - Trégouët, David-Alexandre

AU - Virtamo, Jarmo

AU - Wallentin, Lars

AU - Wareham, Nicholas

AU - Zimmermann, Martina E

AU - Nieminen, Markku S

AU - Hengstenberg, Christian

AU - Sandhu, Manjinder S

AU - Pastinen, Tomi

AU - Syvänen, Ann-Christine

AU - Hovingh, G Kees

AU - Dedoussis, George

AU - Franks, Paul W

AU - Lehtimäki, Terho

AU - Metspalu, Andres

AU - Zalloua, Pierre A

AU - Siegbahn, Agneta

AU - Schreiber, Stefan

AU - Ripatti, Samuli

AU - Blankenberg, Stefan S

AU - Perola, Markus

AU - Clarke, Robert

AU - Boehm, Bernhard O

AU - O'Donnell, Christopher

AU - Reilly, Muredach P

AU - März, Winfried

AU - Collins, Rory

AU - Kathiresan, Sekar

AU - Hamsten, Anders

AU - Kooner, Jaspal S

AU - Thorsteinsdottir, Unnur

AU - Danesh, John

AU - Palmer, Colin N A

AU - Roberts, Robert

AU - Watkins, Hugh

AU - Schunkert, Heribert

AU - Samani, Nilesh J

AU - CARDIoGRAMplusC4D Consortium

PY - 2013/1

Y1 - 2013/1

N2 - Coronary artery disease (CAD) is the commonest cause of death. Here, we report an association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching genome-wide significance, taking the number of susceptibility loci for CAD to 46, and a further 104 independent variants (r(2) < 0.2) strongly associated with CAD at a 5% false discovery rate (FDR). Together, these variants explain approximately 10.6% of CAD heritability. Of the 46 genome-wide significant lead SNPs, 12 show a significant association with a lipid trait, and 5 show a significant association with blood pressure, but none is significantly associated with diabetes. Network analysis with 233 candidate genes (loci at 10% FDR) generated 5 interaction networks comprising 85% of these putative genes involved in CAD. The four most significant pathways mapping to these networks are linked to lipid metabolism and inflammation, underscoring the causal role of these activities in the genetic etiology of CAD. Our study provides insights into the genetic basis of CAD and identifies key biological pathways.

AB - Coronary artery disease (CAD) is the commonest cause of death. Here, we report an association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching genome-wide significance, taking the number of susceptibility loci for CAD to 46, and a further 104 independent variants (r(2) < 0.2) strongly associated with CAD at a 5% false discovery rate (FDR). Together, these variants explain approximately 10.6% of CAD heritability. Of the 46 genome-wide significant lead SNPs, 12 show a significant association with a lipid trait, and 5 show a significant association with blood pressure, but none is significantly associated with diabetes. Network analysis with 233 candidate genes (loci at 10% FDR) generated 5 interaction networks comprising 85% of these putative genes involved in CAD. The four most significant pathways mapping to these networks are linked to lipid metabolism and inflammation, underscoring the causal role of these activities in the genetic etiology of CAD. Our study provides insights into the genetic basis of CAD and identifies key biological pathways.

KW - Adult

KW - Aged

KW - Asian Continental Ancestry Group

KW - Cell Line

KW - Coronary Artery Disease/genetics

KW - European Continental Ancestry Group/genetics

KW - Female

KW - Gene Regulatory Networks

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Humans

KW - Male

KW - Middle Aged

KW - Polymorphism, Single Nucleotide

KW - Quantitative Trait Loci

KW - Risk Factors

U2 - 10.1038/ng.2480

DO - 10.1038/ng.2480

M3 - SCORING: Journal article

C2 - 23202125

VL - 45

SP - 25

EP - 33

JO - NAT GENET

JF - NAT GENET

SN - 1061-4036

IS - 1

ER -