Lactobacillus Acidophilus/Bifidobacterium Infantis Probiotics Are Beneficial to Extremely Low Gestational Age Infants Fed Human Milk
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Lactobacillus Acidophilus/Bifidobacterium Infantis Probiotics Are Beneficial to Extremely Low Gestational Age Infants Fed Human Milk. / Fortmann, Ingmar; Marißen, Janina; Siller, Bastian; Spiegler, Juliane; Humberg, Alexander; Hanke, Kathrin; Faust, Kirstin; Pagel, Julia; Eyvazzadeh, Leila; Brenner, Kim; Roll, Claudia; Pirr, Sabine; Viemann, Dorothee; Stavropoulou, Dimitra; Henneke, Philipp; Tröger, Birte; Körner, Thorsten; Stein, Anja; Derouet, Christoph; Zemlin, Michael; Wieg, Christian; Rupp, Jan; Herting, Egbert; Göpel, Wolfgang; Härtel, Christoph.
In: NUTRIENTS, Vol. 12, No. 3, 22.03.2020.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Lactobacillus Acidophilus/Bifidobacterium Infantis Probiotics Are Beneficial to Extremely Low Gestational Age Infants Fed Human Milk
AU - Fortmann, Ingmar
AU - Marißen, Janina
AU - Siller, Bastian
AU - Spiegler, Juliane
AU - Humberg, Alexander
AU - Hanke, Kathrin
AU - Faust, Kirstin
AU - Pagel, Julia
AU - Eyvazzadeh, Leila
AU - Brenner, Kim
AU - Roll, Claudia
AU - Pirr, Sabine
AU - Viemann, Dorothee
AU - Stavropoulou, Dimitra
AU - Henneke, Philipp
AU - Tröger, Birte
AU - Körner, Thorsten
AU - Stein, Anja
AU - Derouet, Christoph
AU - Zemlin, Michael
AU - Wieg, Christian
AU - Rupp, Jan
AU - Herting, Egbert
AU - Göpel, Wolfgang
AU - Härtel, Christoph
PY - 2020/3/22
Y1 - 2020/3/22
N2 - UNLABELLED: Objective: To evaluate the nutrition-related effects of prophylactic Lactobacillus acidophilus/Bifidobacterium infantis probiotics on the outcomes of preterm infants <29 weeks of gestation that receive human milk and/or formula nutrition. We hypothesize that human-milk-fed infants benefit from probiotics in terms of sepsis prevention and growth.METHODS: We performed an observational study of the German Neonatal Network (GNN) over a period of six years, between 1 January, 2013 and 31 December, 2018. Prophylactic probiotic use of L. acidophilus/B. infantis was evaluated in preterm infants <29 weeks of gestation (n = 7516) in subgroups stratified to feeding type: (I) Exclusively human milk (HM) of own mother and/or donors (HM group, n = 1568), (II) HM of own mother and/or donor and formula (Mix group, n = 5221), and (III) exclusive exposure to formula (F group, n = 727). The effect of probiotics on general outcomes and growth was tested in univariate models and adjusted in linear/logistic regression models.RESULTS: 5954 (76.5%) infants received L. acidophilus/B. infantis prophylactically for the prevention of necrotizing enterocolitis (NEC). Probiotic use was associated with improved growth measures in the HM group (e.g., weight gain velocity in g/day: effect size B = 0.224; 95% CI: 2.82-4.35; p < 0.001) but not in the F group (effect size B = -0.06; 95% CI: -3.05-0.28; p = 0.103). The HM group had the lowest incidence of clinical sepsis (34.0%) as compared to the Mix group (35.5%) and the F group (40.0%). Only in the Mix group, probiotic supplementation proved to be protective against clinical sepsis (OR 0.69; 95% CI: 0.59-0.79; p < 0.001).CONCLUSION: Our observational data indicate that the exposure to L. acidophilus/B. infantis probiotics may promote growth in exclusively HM-fed infants as compared to formula-fed infants. To exert a sepsis-preventive effect, probiotics seem to require human milk.
AB - UNLABELLED: Objective: To evaluate the nutrition-related effects of prophylactic Lactobacillus acidophilus/Bifidobacterium infantis probiotics on the outcomes of preterm infants <29 weeks of gestation that receive human milk and/or formula nutrition. We hypothesize that human-milk-fed infants benefit from probiotics in terms of sepsis prevention and growth.METHODS: We performed an observational study of the German Neonatal Network (GNN) over a period of six years, between 1 January, 2013 and 31 December, 2018. Prophylactic probiotic use of L. acidophilus/B. infantis was evaluated in preterm infants <29 weeks of gestation (n = 7516) in subgroups stratified to feeding type: (I) Exclusively human milk (HM) of own mother and/or donors (HM group, n = 1568), (II) HM of own mother and/or donor and formula (Mix group, n = 5221), and (III) exclusive exposure to formula (F group, n = 727). The effect of probiotics on general outcomes and growth was tested in univariate models and adjusted in linear/logistic regression models.RESULTS: 5954 (76.5%) infants received L. acidophilus/B. infantis prophylactically for the prevention of necrotizing enterocolitis (NEC). Probiotic use was associated with improved growth measures in the HM group (e.g., weight gain velocity in g/day: effect size B = 0.224; 95% CI: 2.82-4.35; p < 0.001) but not in the F group (effect size B = -0.06; 95% CI: -3.05-0.28; p = 0.103). The HM group had the lowest incidence of clinical sepsis (34.0%) as compared to the Mix group (35.5%) and the F group (40.0%). Only in the Mix group, probiotic supplementation proved to be protective against clinical sepsis (OR 0.69; 95% CI: 0.59-0.79; p < 0.001).CONCLUSION: Our observational data indicate that the exposure to L. acidophilus/B. infantis probiotics may promote growth in exclusively HM-fed infants as compared to formula-fed infants. To exert a sepsis-preventive effect, probiotics seem to require human milk.
KW - Bifidobacterium longum subspecies infantis
KW - Dietary Supplements
KW - Enterocolitis, Necrotizing/prevention & control
KW - Female
KW - Gestational Age
KW - Humans
KW - Infant Formula
KW - Infant Nutritional Physiological Phenomena
KW - Infant, Newborn
KW - Infant, Premature/growth & development
KW - Lactobacillus acidophilus
KW - Male
KW - Milk, Human
KW - Pre-Exposure Prophylaxis
KW - Probiotics/administration & dosage
KW - Sepsis/prevention & control
U2 - 10.3390/nu12030850
DO - 10.3390/nu12030850
M3 - SCORING: Journal article
C2 - 32235769
VL - 12
JO - NUTRIENTS
JF - NUTRIENTS
SN - 2072-6643
IS - 3
ER -
