Lack of microbiota reduces innate responses and enhances adaptive immunity against Listeria monocytogenes infection

Hans-Willi Mittrücker; Daniel Seidel; Paul W Bland; Agnieszka Zarzycka; Stefan H E Kaufmann; Alexander Visekruna; Ulrich Steinhoff

doi:10.1002/eji.201343927

Lack of microbiota reduces innate responses and enhances adaptive immunity against Listeria monocytogenes infection

Standard

Lack of microbiota reduces innate responses and enhances adaptive immunity against Listeria monocytogenes infection. / Mittrücker, Hans-Willi; Seidel, Daniel; Bland, Paul W; Zarzycka, Agnieszka; Kaufmann, Stefan H E; Visekruna, Alexander; Steinhoff, Ulrich.

In: EUR J IMMUNOL, Vol. 44, No. 6, 01.06.2014, p. 1710-5.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Mittrücker, H-W, Seidel, D, Bland, PW, Zarzycka, A, Kaufmann, SHE, Visekruna, A & Steinhoff, U 2014, 'Lack of microbiota reduces innate responses and enhances adaptive immunity against Listeria monocytogenes infection', EUR J IMMUNOL, vol. 44, no. 6, pp. 1710-5. https://doi.org/10.1002/eji.201343927

APA

Mittrücker, H-W., Seidel, D., Bland, P. W., Zarzycka, A., Kaufmann, S. H. E., Visekruna, A., & Steinhoff, U. (2014). Lack of microbiota reduces innate responses and enhances adaptive immunity against Listeria monocytogenes infection. EUR J IMMUNOL, 44(6), 1710-5. https://doi.org/10.1002/eji.201343927

Vancouver

Mittrücker H-W, Seidel D, Bland PW, Zarzycka A, Kaufmann SHE, Visekruna A et al. Lack of microbiota reduces innate responses and enhances adaptive immunity against Listeria monocytogenes infection. EUR J IMMUNOL. 2014 Jun 1;44(6):1710-5. https://doi.org/10.1002/eji.201343927

Bibtex

@article{722b876637c94020aa3f725126f333e5,

title = "Lack of microbiota reduces innate responses and enhances adaptive immunity against Listeria monocytogenes infection",

abstract = "The intestinal microbiota influences not only metabolic processes, but also the mucosal and systemic immune systems. Here, we compare innate and adaptive immune responses against the intracellular pathogen Listeria monocytogenes in germfree (GF) and conventional mice. We show that animals without endogenous microbiota are highly susceptible to primary infection with impaired activation and accumulation of phagocytes to the site of infection. Unexpectedly, secondary infection with otherwise lethal dose resulted in survival of all GF animals which cleared bacteria more rapidly and developed a stronger antilisterial CD8(+) memory T-cell response compared to conventional mice. In summary, lack of the intestinal microbiota impairs early innate immunity, but enhances activation and expansion of memory T cells.",

author = "Hans-Willi Mittr{\"u}cker and Daniel Seidel and Bland, {Paul W} and Agnieszka Zarzycka and Kaufmann, {Stefan H E} and Alexander Visekruna and Ulrich Steinhoff",

note = "{\textcopyright} 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",

year = "2014",

month = jun,

day = "1",

doi = "10.1002/eji.201343927",

language = "English",

volume = "44",

pages = "1710--5",

journal = "EUR J IMMUNOL",

issn = "0014-2980",

publisher = "Wiley-VCH Verlag GmbH",

number = "6",

}

RIS

TY - JOUR

T1 - Lack of microbiota reduces innate responses and enhances adaptive immunity against Listeria monocytogenes infection

AU - Mittrücker, Hans-Willi

AU - Seidel, Daniel

AU - Bland, Paul W

AU - Zarzycka, Agnieszka

AU - Kaufmann, Stefan H E

AU - Visekruna, Alexander

AU - Steinhoff, Ulrich

PY - 2014/6/1

Y1 - 2014/6/1

N2 - The intestinal microbiota influences not only metabolic processes, but also the mucosal and systemic immune systems. Here, we compare innate and adaptive immune responses against the intracellular pathogen Listeria monocytogenes in germfree (GF) and conventional mice. We show that animals without endogenous microbiota are highly susceptible to primary infection with impaired activation and accumulation of phagocytes to the site of infection. Unexpectedly, secondary infection with otherwise lethal dose resulted in survival of all GF animals which cleared bacteria more rapidly and developed a stronger antilisterial CD8(+) memory T-cell response compared to conventional mice. In summary, lack of the intestinal microbiota impairs early innate immunity, but enhances activation and expansion of memory T cells.

AB - The intestinal microbiota influences not only metabolic processes, but also the mucosal and systemic immune systems. Here, we compare innate and adaptive immune responses against the intracellular pathogen Listeria monocytogenes in germfree (GF) and conventional mice. We show that animals without endogenous microbiota are highly susceptible to primary infection with impaired activation and accumulation of phagocytes to the site of infection. Unexpectedly, secondary infection with otherwise lethal dose resulted in survival of all GF animals which cleared bacteria more rapidly and developed a stronger antilisterial CD8(+) memory T-cell response compared to conventional mice. In summary, lack of the intestinal microbiota impairs early innate immunity, but enhances activation and expansion of memory T cells.

U2 - 10.1002/eji.201343927

DO - 10.1002/eji.201343927

M3 - SCORING: Journal article

C2 - 24643764

VL - 44

SP - 1710

EP - 1715

JO - EUR J IMMUNOL

JF - EUR J IMMUNOL

SN - 0014-2980

IS - 6

ER -