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Lack of evidence that myelin-associated glycoprotein is a major inhibitor of axonal regeneration in the CNS

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Lack of evidence that myelin-associated glycoprotein is a major inhibitor of axonal regeneration in the CNS. / Bartsch, U; Bandtlow, C E; Schnell, L; Bartsch, S; Spillmann, A A; Rubin, B P; Hillenbrand, R; Montag, D; Schwab, M E; Schachner, M.

In: NEURON, Vol. 15, No. 6, 12.1995, p. 1375-81.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Bartsch, U, Bandtlow, CE, Schnell, L, Bartsch, S, Spillmann, AA, Rubin, BP, Hillenbrand, R, Montag, D, Schwab, ME & Schachner, M 1995, 'Lack of evidence that myelin-associated glycoprotein is a major inhibitor of axonal regeneration in the CNS', NEURON, vol. 15, no. 6, pp. 1375-81.

APA

Bartsch, U., Bandtlow, C. E., Schnell, L., Bartsch, S., Spillmann, A. A., Rubin, B. P., Hillenbrand, R., Montag, D., Schwab, M. E., & Schachner, M. (1995). Lack of evidence that myelin-associated glycoprotein is a major inhibitor of axonal regeneration in the CNS. NEURON, 15(6), 1375-81.

Vancouver

Bartsch U, Bandtlow CE, Schnell L, Bartsch S, Spillmann AA, Rubin BP et al. Lack of evidence that myelin-associated glycoprotein is a major inhibitor of axonal regeneration in the CNS. NEURON. 1995 Dec;15(6):1375-81.

Bibtex

@article{2b1b728434dc407fab0080a129ebee8c,
title = "Lack of evidence that myelin-associated glycoprotein is a major inhibitor of axonal regeneration in the CNS",
abstract = "The MAG-deficient mouse was used to test whether MAG acts as a significant inhibitor of axonal regeneration in the adult mammalian CNS, as suggested by cell culture experiments. Cell spreading, neurite elongation, or growth cone collapse of different cell types in vitro was not significantly different when myelin preparations or optic nerve cryosections from either MAG-deficient or wild-type mice were used as a substrate. More importantly, the extent of axonal regrowth in lesioned optic nerve and corticospinal tract in vivo was similarly poor in MAG-deficient and wild-type mice. However, axonal regrowth increased significantly and to a similar extent in both genotypes after application of the IN-1 antibody directed against the neurite growth inhibitors NI-35 and NI-250. These observations do not support the view that MAG is a significant inhibitor of axonal regeneration in the adult CNS.",
keywords = "3T3 Cells, Animals, Axons, Central Nervous System, Cerebellum, Ganglia, Spinal, Growth Inhibitors, Mice, Mice, Mutant Strains, Myelin Proteins, Myelin-Associated Glycoprotein, Nerve Regeneration, Neural Inhibition, Neurites, Neurons, Optic Nerve, PC12 Cells, Pyramidal Tracts, Rats, Tumor Cells, Cultured, Journal Article, Research Support, Non-U.S. Gov't",
author = "U Bartsch and Bandtlow, {C E} and L Schnell and S Bartsch and Spillmann, {A A} and Rubin, {B P} and R Hillenbrand and D Montag and Schwab, {M E} and M Schachner",
year = "1995",
month = dec,
language = "English",
volume = "15",
pages = "1375--81",
journal = "NEURON",
issn = "0896-6273",
publisher = "Cell Press",
number = "6",

}

RIS

TY - JOUR

T1 - Lack of evidence that myelin-associated glycoprotein is a major inhibitor of axonal regeneration in the CNS

AU - Bartsch, U

AU - Bandtlow, C E

AU - Schnell, L

AU - Bartsch, S

AU - Spillmann, A A

AU - Rubin, B P

AU - Hillenbrand, R

AU - Montag, D

AU - Schwab, M E

AU - Schachner, M

PY - 1995/12

Y1 - 1995/12

N2 - The MAG-deficient mouse was used to test whether MAG acts as a significant inhibitor of axonal regeneration in the adult mammalian CNS, as suggested by cell culture experiments. Cell spreading, neurite elongation, or growth cone collapse of different cell types in vitro was not significantly different when myelin preparations or optic nerve cryosections from either MAG-deficient or wild-type mice were used as a substrate. More importantly, the extent of axonal regrowth in lesioned optic nerve and corticospinal tract in vivo was similarly poor in MAG-deficient and wild-type mice. However, axonal regrowth increased significantly and to a similar extent in both genotypes after application of the IN-1 antibody directed against the neurite growth inhibitors NI-35 and NI-250. These observations do not support the view that MAG is a significant inhibitor of axonal regeneration in the adult CNS.

AB - The MAG-deficient mouse was used to test whether MAG acts as a significant inhibitor of axonal regeneration in the adult mammalian CNS, as suggested by cell culture experiments. Cell spreading, neurite elongation, or growth cone collapse of different cell types in vitro was not significantly different when myelin preparations or optic nerve cryosections from either MAG-deficient or wild-type mice were used as a substrate. More importantly, the extent of axonal regrowth in lesioned optic nerve and corticospinal tract in vivo was similarly poor in MAG-deficient and wild-type mice. However, axonal regrowth increased significantly and to a similar extent in both genotypes after application of the IN-1 antibody directed against the neurite growth inhibitors NI-35 and NI-250. These observations do not support the view that MAG is a significant inhibitor of axonal regeneration in the adult CNS.

KW - 3T3 Cells

KW - Animals

KW - Axons

KW - Central Nervous System

KW - Cerebellum

KW - Ganglia, Spinal

KW - Growth Inhibitors

KW - Mice

KW - Mice, Mutant Strains

KW - Myelin Proteins

KW - Myelin-Associated Glycoprotein

KW - Nerve Regeneration

KW - Neural Inhibition

KW - Neurites

KW - Neurons

KW - Optic Nerve

KW - PC12 Cells

KW - Pyramidal Tracts

KW - Rats

KW - Tumor Cells, Cultured

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

M3 - SCORING: Journal article

C2 - 8845160

VL - 15

SP - 1375

EP - 1381

JO - NEURON

JF - NEURON

SN - 0896-6273

IS - 6

ER -