Research ExplorerPublicationsLack of association between CD40 polymorphisms and acute rej...

Lack of association between CD40 polymorphisms and acute rejection in German liver transplant recipients

Standard

Lack of association between CD40 polymorphisms and acute rejection in German liver transplant recipients. / Thude, Hansjörg; Kramer, Kathrin; Koch, Martina; Peine, Sven; Sterneck, Martina; Nashan, Björn.

In: HUM IMMUNOL, Vol. 75, No. 11, 01.11.2014, p. 1123-7.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Thude, H, Kramer, K, Koch, M, Peine, S, Sterneck, M & Nashan, B 2014, 'Lack of association between CD40 polymorphisms and acute rejection in German liver transplant recipients', HUM IMMUNOL, vol. 75, no. 11, pp. 1123-7. https://doi.org/10.1016/j.humimm.2014.09.024

APA

Thude, H., Kramer, K., Koch, M., Peine, S., Sterneck, M., & Nashan, B. (2014). Lack of association between CD40 polymorphisms and acute rejection in German liver transplant recipients. HUM IMMUNOL, 75(11), 1123-7. https://doi.org/10.1016/j.humimm.2014.09.024

Vancouver

Thude H, Kramer K, Koch M, Peine S, Sterneck M, Nashan B. Lack of association between CD40 polymorphisms and acute rejection in German liver transplant recipients. HUM IMMUNOL. 2014 Nov 1;75(11):1123-7. https://doi.org/10.1016/j.humimm.2014.09.024

Bibtex

@article{e517e5d948e04748afc636cfd92f078d,
title = "Lack of association between CD40 polymorphisms and acute rejection in German liver transplant recipients",
abstract = "CD40 and its ligand, CD154, are major costimulatory molecules whose interactions are important in alloreactive transplant rejection. The aim of this study was to examine the association of CD40 polymorphisms with the susceptibility to acute rejection episodes in liver transplantation. In total, 112 liver transplant recipients with biopsy proven acute rejections (BPAR), 97 without BPAR (WBPAR), and 112 healthy control individuals were enrolled in the study. Two single nucleotide polymorphisms (SNPs) of CD40 gene (rs1883832 and rs4810485) were genotyped by polymerase chain reaction-allele specific restriction enzyme analysis (PCR-ASRA). Both SNPs has been tested for a recessive and a dominant model. No significant differences were found in the genotype and allele frequencies of the SNPs rs1883832 and rs4810485 between BPAR liver recipients and WBPAR recipients. Our results do not suggest an important role of tested CD40 SNPs in the susceptibility to acute liver transplant rejection in a Caucasian population.",
author = "Hansj{\"o}rg Thude and Kathrin Kramer and Martina Koch and Sven Peine and Martina Sterneck and Bj{\"o}rn Nashan",
note = "Copyright {\textcopyright} 2014 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.",
year = "2014",
month = nov,
day = "1",
doi = "10.1016/j.humimm.2014.09.024",
language = "English",
volume = "75",
pages = "1123--7",
journal = "HUM IMMUNOL",
issn = "0198-8859",
publisher = "Elsevier Inc.",
number = "11",

}

RIS

TY - JOUR

T1 - Lack of association between CD40 polymorphisms and acute rejection in German liver transplant recipients

AU - Thude, Hansjörg

AU - Kramer, Kathrin

AU - Koch, Martina

AU - Peine, Sven

AU - Sterneck, Martina

AU - Nashan, Björn

N1 - Copyright © 2014 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

PY - 2014/11/1

Y1 - 2014/11/1

N2 - CD40 and its ligand, CD154, are major costimulatory molecules whose interactions are important in alloreactive transplant rejection. The aim of this study was to examine the association of CD40 polymorphisms with the susceptibility to acute rejection episodes in liver transplantation. In total, 112 liver transplant recipients with biopsy proven acute rejections (BPAR), 97 without BPAR (WBPAR), and 112 healthy control individuals were enrolled in the study. Two single nucleotide polymorphisms (SNPs) of CD40 gene (rs1883832 and rs4810485) were genotyped by polymerase chain reaction-allele specific restriction enzyme analysis (PCR-ASRA). Both SNPs has been tested for a recessive and a dominant model. No significant differences were found in the genotype and allele frequencies of the SNPs rs1883832 and rs4810485 between BPAR liver recipients and WBPAR recipients. Our results do not suggest an important role of tested CD40 SNPs in the susceptibility to acute liver transplant rejection in a Caucasian population.

AB - CD40 and its ligand, CD154, are major costimulatory molecules whose interactions are important in alloreactive transplant rejection. The aim of this study was to examine the association of CD40 polymorphisms with the susceptibility to acute rejection episodes in liver transplantation. In total, 112 liver transplant recipients with biopsy proven acute rejections (BPAR), 97 without BPAR (WBPAR), and 112 healthy control individuals were enrolled in the study. Two single nucleotide polymorphisms (SNPs) of CD40 gene (rs1883832 and rs4810485) were genotyped by polymerase chain reaction-allele specific restriction enzyme analysis (PCR-ASRA). Both SNPs has been tested for a recessive and a dominant model. No significant differences were found in the genotype and allele frequencies of the SNPs rs1883832 and rs4810485 between BPAR liver recipients and WBPAR recipients. Our results do not suggest an important role of tested CD40 SNPs in the susceptibility to acute liver transplant rejection in a Caucasian population.

U2 - 10.1016/j.humimm.2014.09.024

DO - 10.1016/j.humimm.2014.09.024

M3 - SCORING: Journal article

C2 - 25305459

VL - 75

SP - 1123

EP - 1127

JO - HUM IMMUNOL

JF - HUM IMMUNOL

SN - 0198-8859

IS - 11

ER -