Labral calcification in end-stage osteoarthritis of the hip correlates with pain and clinical function
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Labral calcification in end-stage osteoarthritis of the hip correlates with pain and clinical function. / Hubert, Jan; Hawellek, Thelonius; Moe, Martin; Hischke, Sandra; Krause, Matthias; Rolvien, Tim; Schmidt, Tobias; Rüther, Wolfgang; Niemeier, Andreas.
In: J ORTHOP RES, Vol. 36, No. 4, 04.2018, p. 1248-1255.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Labral calcification in end-stage osteoarthritis of the hip correlates with pain and clinical function
AU - Hubert, Jan
AU - Hawellek, Thelonius
AU - Moe, Martin
AU - Hischke, Sandra
AU - Krause, Matthias
AU - Rolvien, Tim
AU - Schmidt, Tobias
AU - Rüther, Wolfgang
AU - Niemeier, Andreas
N1 - This article is protected by copyright. All rights reserved.
PY - 2018/4
Y1 - 2018/4
N2 - The acetabular labrum of the hip (ALH) is recognized as a clinically important structure, but knowledge about the pathophysiology of this fibrocartilage is scarce. In this prospective study we determined the prevalence of ALH calcification in patients with end-stage osteoarthritis (OA) and analyzed the relationship of cartilage calcification (CC) with hip pain and clinical function. Cohort of 80 patients (70.2 ± 7.6years) with primary OA scheduled for total hip replacement. Harris Hip Score (HHS) was recorded preoperatively. Total ALH and femoral head (FH) were sampled intraoperatively. CC of the ALH and FH was analyzed by high-resolution digital contact radiography. Histological degeneration of the ALH (Krenn-Score) and FH (OARSI-Score) was determined. Multivariate linear regression model and partial correlation analyses were performed. The prevalence of cartilage calcification both in the ALH and FH was 100%, while the amount of CC in the ALH was 1.55 times higher than in the FH (p < 0.001). There was a significant inverse regression between the amount of calcification of both the ALH and the FH and preoperative HHS (βALH = -2.1, p = 0.04), (βFH = -2.9, p = 0.005), but pain was influenced only by ALH calcification (βALH = -2.7, p = 0.008). Age-adjusted, there was a significant correlation between cartilage calcification and histological degeneration (ALH:rs = 0.53, p < 0.001/FH: rs = 0.30, p = 0.007). Fibrocartilage and articular cartilage calcification are inseparable pathological findings in end-stage osteoarthritis of the hip. Fibrocartilage calcification is associated with poor and painful hip function.CLINICAL SIGNIFICANCE: ALH fibrocartilage appears to be particularly prone to calcification, which may explain higher pain levels in individuals with a high degree of ALH calcification independent of age and histological degeneration. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1248-1255, 2018.
AB - The acetabular labrum of the hip (ALH) is recognized as a clinically important structure, but knowledge about the pathophysiology of this fibrocartilage is scarce. In this prospective study we determined the prevalence of ALH calcification in patients with end-stage osteoarthritis (OA) and analyzed the relationship of cartilage calcification (CC) with hip pain and clinical function. Cohort of 80 patients (70.2 ± 7.6years) with primary OA scheduled for total hip replacement. Harris Hip Score (HHS) was recorded preoperatively. Total ALH and femoral head (FH) were sampled intraoperatively. CC of the ALH and FH was analyzed by high-resolution digital contact radiography. Histological degeneration of the ALH (Krenn-Score) and FH (OARSI-Score) was determined. Multivariate linear regression model and partial correlation analyses were performed. The prevalence of cartilage calcification both in the ALH and FH was 100%, while the amount of CC in the ALH was 1.55 times higher than in the FH (p < 0.001). There was a significant inverse regression between the amount of calcification of both the ALH and the FH and preoperative HHS (βALH = -2.1, p = 0.04), (βFH = -2.9, p = 0.005), but pain was influenced only by ALH calcification (βALH = -2.7, p = 0.008). Age-adjusted, there was a significant correlation between cartilage calcification and histological degeneration (ALH:rs = 0.53, p < 0.001/FH: rs = 0.30, p = 0.007). Fibrocartilage and articular cartilage calcification are inseparable pathological findings in end-stage osteoarthritis of the hip. Fibrocartilage calcification is associated with poor and painful hip function.CLINICAL SIGNIFICANCE: ALH fibrocartilage appears to be particularly prone to calcification, which may explain higher pain levels in individuals with a high degree of ALH calcification independent of age and histological degeneration. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1248-1255, 2018.
KW - Journal Article
U2 - 10.1002/jor.23736
DO - 10.1002/jor.23736
M3 - SCORING: Journal article
C2 - 28906050
VL - 36
SP - 1248
EP - 1255
JO - J ORTHOP RES
JF - J ORTHOP RES
SN - 0736-0266
IS - 4
ER -