L1 (CD171) is highly expressed in gastrointestinal stromal tumors.
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L1 (CD171) is highly expressed in gastrointestinal stromal tumors. / Kaifi, Jussuf; Strelow, Andrea; Schurr, Paulus; Reichelt, Uta; Yekebas, Emre F; Wachowiak, Robin; Quaas, Alexander; Strate, Tim; Schaefer, Hansjoerg; Sauter, Guido; Schachner, Melitta; Izbicki, Jakob R.
In: MODERN PATHOL, Vol. 19, No. 3, 3, 2006, p. 399-406.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - L1 (CD171) is highly expressed in gastrointestinal stromal tumors.
AU - Kaifi, Jussuf
AU - Strelow, Andrea
AU - Schurr, Paulus
AU - Reichelt, Uta
AU - Yekebas, Emre F
AU - Wachowiak, Robin
AU - Quaas, Alexander
AU - Strate, Tim
AU - Schaefer, Hansjoerg
AU - Sauter, Guido
AU - Schachner, Melitta
AU - Izbicki, Jakob R
PY - 2006
Y1 - 2006
N2 - The treatment strategy for mesenchymal tumors of the gastrointestinal tract is based upon typing of the tumor. Especially differential diagnosis of gastrointestinal stromal tumors (GISTs) to leiomyomas is crucial for determining radicality of surgery. L1 cell adhesion molecule (CD171) plays an essential role in tumor progression. The aim of this study was to determine expression of L1 in GISTs, smooth muscle tumors, desmoid-type fibromatosis and peripheral nerve sheath tumors (PNSTs). We retrospectively analyzed a total of 129 surgically resected primary tumors or metastases of 72 GISTs, 29 smooth muscle tumors, seven PNSTs and 21 desmoid-type fibromatosis by immunohistochemistry for c-kit, CD34, smooth muscle actin, desmin, vimentin, S-100 and L1 expression. L1 expression was detected in 53 (74%) of 72 GISTs but in none of 29 smooth muscle tumors or 21 desmoid-type fibromatosis (P
AB - The treatment strategy for mesenchymal tumors of the gastrointestinal tract is based upon typing of the tumor. Especially differential diagnosis of gastrointestinal stromal tumors (GISTs) to leiomyomas is crucial for determining radicality of surgery. L1 cell adhesion molecule (CD171) plays an essential role in tumor progression. The aim of this study was to determine expression of L1 in GISTs, smooth muscle tumors, desmoid-type fibromatosis and peripheral nerve sheath tumors (PNSTs). We retrospectively analyzed a total of 129 surgically resected primary tumors or metastases of 72 GISTs, 29 smooth muscle tumors, seven PNSTs and 21 desmoid-type fibromatosis by immunohistochemistry for c-kit, CD34, smooth muscle actin, desmin, vimentin, S-100 and L1 expression. L1 expression was detected in 53 (74%) of 72 GISTs but in none of 29 smooth muscle tumors or 21 desmoid-type fibromatosis (P
M3 - SCORING: Zeitschriftenaufsatz
VL - 19
SP - 399
EP - 406
JO - MODERN PATHOL
JF - MODERN PATHOL
SN - 0893-3952
IS - 3
M1 - 3
ER -