Kortikosteroide in der Intensivmedizin
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Kortikosteroide in der Intensivmedizin. / Sensen, Barbara; Nierhaus, Axel; Kluge, Stefan.
In: DEUT MED WOCHENSCHR, Vol. 149, No. 12, 06.2024, p. 714-718.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - Kortikosteroide in der Intensivmedizin
AU - Sensen, Barbara
AU - Nierhaus, Axel
AU - Kluge, Stefan
N1 - Thieme. All rights reserved.
PY - 2024/6
Y1 - 2024/6
N2 - In the case of septic shock, recent studies show benefits from a combination of hydrocortisone and fludrocortisone, but clear guideline recommendations are still lacking. For severe community-acquired pneumonia, early corticosteroid therapy is recommended. Corticosteroid therapy should not be used in influenza-associated community-acquired pneumonia. In contrast, a significantly lower 28-day mortality rate was observed for COVID-19 by the use of dexamethasone. Current guidelines also recommend the use of corticosteroids in Acute Respiratory Distress Syndrome. These recommendations are based primarily on studies that started steroid therapy early. However, many questions such as the type of corticosteroid, the timing and duration of therapy, and the dosage still remain unanswered.
AB - In the case of septic shock, recent studies show benefits from a combination of hydrocortisone and fludrocortisone, but clear guideline recommendations are still lacking. For severe community-acquired pneumonia, early corticosteroid therapy is recommended. Corticosteroid therapy should not be used in influenza-associated community-acquired pneumonia. In contrast, a significantly lower 28-day mortality rate was observed for COVID-19 by the use of dexamethasone. Current guidelines also recommend the use of corticosteroids in Acute Respiratory Distress Syndrome. These recommendations are based primarily on studies that started steroid therapy early. However, many questions such as the type of corticosteroid, the timing and duration of therapy, and the dosage still remain unanswered.
KW - Humans
KW - Critical Care
KW - Adrenal Cortex Hormones/therapeutic use
KW - Shock, Septic/drug therapy
KW - Respiratory Distress Syndrome/drug therapy
KW - Community-Acquired Infections/drug therapy
KW - COVID-19/mortality
KW - COVID-19 Drug Treatment
KW - Dexamethasone/therapeutic use
KW - Hydrocortisone/therapeutic use
KW - Practice Guidelines as Topic
U2 - 10.1055/a-2128-5319
DO - 10.1055/a-2128-5319
M3 - SCORING: Review
C2 - 38781995
VL - 149
SP - 714
EP - 718
JO - DEUT MED WOCHENSCHR
JF - DEUT MED WOCHENSCHR
SN - 0012-0472
IS - 12
ER -
