JNK signaling coordinates with ecdysone signaling to promote pruning of Drosophila sensory neuron dendrites

Sijun Zhu; Rui Chen; Peter Soba; Yuh-Nung Jan

doi:10.1242/dev.163592

JNK signaling coordinates with ecdysone signaling to promote pruning of Drosophila sensory neuron dendrites

Standard

JNK signaling coordinates with ecdysone signaling to promote pruning of Drosophila sensory neuron dendrites. / Zhu, Sijun; Chen, Rui; Soba, Peter; Jan, Yuh-Nung.

In: DEVELOPMENT, Vol. 146, No. 8, 17.04.2019.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Zhu, S, Chen, R, Soba, P & Jan, Y-N 2019, 'JNK signaling coordinates with ecdysone signaling to promote pruning of Drosophila sensory neuron dendrites', DEVELOPMENT, vol. 146, no. 8. https://doi.org/10.1242/dev.163592

APA

Zhu, S., Chen, R., Soba, P., & Jan, Y-N. (2019). JNK signaling coordinates with ecdysone signaling to promote pruning of Drosophila sensory neuron dendrites. DEVELOPMENT, 146(8). https://doi.org/10.1242/dev.163592

Vancouver

Zhu S, Chen R, Soba P, Jan Y-N. JNK signaling coordinates with ecdysone signaling to promote pruning of Drosophila sensory neuron dendrites. DEVELOPMENT. 2019 Apr 17;146(8). https://doi.org/10.1242/dev.163592

Bibtex

@article{b5a50009617c48b9bba875b6ea3281c6,

title = "JNK signaling coordinates with ecdysone signaling to promote pruning of Drosophila sensory neuron dendrites",

abstract = "Developmental pruning of axons and dendrites is crucial for the formation of precise neuronal connections, but the mechanisms underlying developmental pruning are not fully understood. Here, we have investigated the function of JNK signaling in dendrite pruning using Drosophila class IV dendritic arborization (c4da) neurons as a model. We find that loss of JNK or its canonical downstream effectors Jun or Fos led to dendrite-pruning defects in c4da neurons. Interestingly, our data show that JNK activity in c4da neurons remains constant from larval to pupal stages but the expression of Fos is specifically activated by ecdysone receptor B1 (EcRB1) at early pupal stages, suggesting that ecdysone signaling provides temporal control of the regulation of dendrite pruning by JNK signaling. Thus, our work not only identifies a novel pathway involved in dendrite pruning and a new downstream target of EcRB1 in c4da neurons, but also reveals that JNK and Ecdysone signaling coordinate to promote dendrite pruning. ",

keywords = "Journal Article",

author = "Sijun Zhu and Rui Chen and Peter Soba and Yuh-Nung Jan",

note = "{\textcopyright} 2019. Published by The Company of Biologists Ltd.",

year = "2019",

month = apr,

day = "17",

doi = "10.1242/dev.163592",

language = "English",

volume = "146",

journal = "DEVELOPMENT",

issn = "0950-1991",

publisher = "Company of Biologists Ltd",

number = "8",

}

RIS

TY - JOUR

T1 - JNK signaling coordinates with ecdysone signaling to promote pruning of Drosophila sensory neuron dendrites

AU - Zhu, Sijun

AU - Chen, Rui

AU - Soba, Peter

AU - Jan, Yuh-Nung

PY - 2019/4/17

Y1 - 2019/4/17

N2 - Developmental pruning of axons and dendrites is crucial for the formation of precise neuronal connections, but the mechanisms underlying developmental pruning are not fully understood. Here, we have investigated the function of JNK signaling in dendrite pruning using Drosophila class IV dendritic arborization (c4da) neurons as a model. We find that loss of JNK or its canonical downstream effectors Jun or Fos led to dendrite-pruning defects in c4da neurons. Interestingly, our data show that JNK activity in c4da neurons remains constant from larval to pupal stages but the expression of Fos is specifically activated by ecdysone receptor B1 (EcRB1) at early pupal stages, suggesting that ecdysone signaling provides temporal control of the regulation of dendrite pruning by JNK signaling. Thus, our work not only identifies a novel pathway involved in dendrite pruning and a new downstream target of EcRB1 in c4da neurons, but also reveals that JNK and Ecdysone signaling coordinate to promote dendrite pruning.

AB - Developmental pruning of axons and dendrites is crucial for the formation of precise neuronal connections, but the mechanisms underlying developmental pruning are not fully understood. Here, we have investigated the function of JNK signaling in dendrite pruning using Drosophila class IV dendritic arborization (c4da) neurons as a model. We find that loss of JNK or its canonical downstream effectors Jun or Fos led to dendrite-pruning defects in c4da neurons. Interestingly, our data show that JNK activity in c4da neurons remains constant from larval to pupal stages but the expression of Fos is specifically activated by ecdysone receptor B1 (EcRB1) at early pupal stages, suggesting that ecdysone signaling provides temporal control of the regulation of dendrite pruning by JNK signaling. Thus, our work not only identifies a novel pathway involved in dendrite pruning and a new downstream target of EcRB1 in c4da neurons, but also reveals that JNK and Ecdysone signaling coordinate to promote dendrite pruning.

KW - Journal Article

U2 - 10.1242/dev.163592

DO - 10.1242/dev.163592

M3 - SCORING: Journal article

C2 - 30936183

VL - 146

JO - DEVELOPMENT

JF - DEVELOPMENT

SN - 0950-1991

IS - 8

ER -