Jacob, a Synapto-Nuclear Protein Messenger Linking N-methyl-D-aspartate Receptor Activation to Nuclear Gene Expression
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Jacob, a Synapto-Nuclear Protein Messenger Linking N-methyl-D-aspartate Receptor Activation to Nuclear Gene Expression. / Grochowska, Katarzyna M; Bär, Julia; Gomes, Guilherme M; Kreutz, Michael R; Karpova, Anna.
In: FRONT SYNAPTIC NEURO, Vol. 13, 787494, 11.2021.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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T1 - Jacob, a Synapto-Nuclear Protein Messenger Linking N-methyl-D-aspartate Receptor Activation to Nuclear Gene Expression
AU - Grochowska, Katarzyna M
AU - Bär, Julia
AU - Gomes, Guilherme M
AU - Kreutz, Michael R
AU - Karpova, Anna
N1 - Copyright © 2021 Grochowska, Bär, Gomes, Kreutz and Karpova.
PY - 2021/11
Y1 - 2021/11
N2 - Pyramidal neurons exhibit a complex dendritic tree that is decorated by a huge number of spine synapses receiving excitatory input. Synaptic signals not only act locally but are also conveyed to the nucleus of the postsynaptic neuron to regulate gene expression. This raises the question of how the spatio-temporal integration of synaptic inputs is accomplished at the genomic level and which molecular mechanisms are involved. Protein transport from synapse to nucleus has been shown in several studies and has the potential to encode synaptic signals at the site of origin and decode them in the nucleus. In this review, we summarize the knowledge about the properties of the synapto-nuclear messenger protein Jacob with special emphasis on a putative role in hippocampal neuronal plasticity. We will elaborate on the interactome of Jacob, the signals that control synapto-nuclear trafficking, the mechanisms of transport, and the potential nuclear function. In addition, we will address the organization of the Jacob/NSMF gene, its origin and we will summarize the evidence for the existence of splice isoforms and their expression pattern.
AB - Pyramidal neurons exhibit a complex dendritic tree that is decorated by a huge number of spine synapses receiving excitatory input. Synaptic signals not only act locally but are also conveyed to the nucleus of the postsynaptic neuron to regulate gene expression. This raises the question of how the spatio-temporal integration of synaptic inputs is accomplished at the genomic level and which molecular mechanisms are involved. Protein transport from synapse to nucleus has been shown in several studies and has the potential to encode synaptic signals at the site of origin and decode them in the nucleus. In this review, we summarize the knowledge about the properties of the synapto-nuclear messenger protein Jacob with special emphasis on a putative role in hippocampal neuronal plasticity. We will elaborate on the interactome of Jacob, the signals that control synapto-nuclear trafficking, the mechanisms of transport, and the potential nuclear function. In addition, we will address the organization of the Jacob/NSMF gene, its origin and we will summarize the evidence for the existence of splice isoforms and their expression pattern.
U2 - 10.3389/fnsyn.2021.787494
DO - 10.3389/fnsyn.2021.787494
M3 - SCORING: Review article
C2 - 34899262
VL - 13
JO - FRONT SYNAPTIC NEURO
JF - FRONT SYNAPTIC NEURO
SN - 1663-3563
M1 - 787494
ER -
