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Is There an Impact of Transperineal Versus Transrectal Magnetic Resonance Imaging-targeted Biopsy on the Risk of Upgrading in Final Pathology in Prostate Cancer Patients Undergoing Radical Prostatectomy? An European Association of Urology-Young Academic Urologists Prostate Cancer Working Group Multi-institutional Study

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Is There an Impact of Transperineal Versus Transrectal Magnetic Resonance Imaging-targeted Biopsy on the Risk of Upgrading in Final Pathology in Prostate Cancer Patients Undergoing Radical Prostatectomy? An European Association of Urology-Young Academic Urologists Prostate Cancer Working Group Multi-institutional Study. / Zattoni, Fabio; Marra, Giancarlo; Martini, Alberto; Kasivisvanathan, Veeru; Grummet, Jeremy; Harkin, Timothy; Ploussard, Guillaume; Olivier, Jonathan; Chiu, Peter K; Valerio, Massimo; Marquis, Alessandro; Gontero, Paolo; Guo, Hongqian; Zhuang, Junlong; Frydenberg, Mark; Moon, Daniel; Morlacco, Alessandro; Kretschmer, Alexander; Barletta, Francesco; Heidegger, Isabel; Tilki, Derya; van den Bergh, Roderick; Dal Moro, Fabrizio; Briganti, Alberto; Montorsi, Francesco; Novara, Giacomo; Gandaglia, Giorgio; EAU-YAU Prostate Cancer Working Group.

In: EUR UROL FOCUS, Vol. 9, No. 4, 07.2023, p. 621-628.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Zattoni, F, Marra, G, Martini, A, Kasivisvanathan, V, Grummet, J, Harkin, T, Ploussard, G, Olivier, J, Chiu, PK, Valerio, M, Marquis, A, Gontero, P, Guo, H, Zhuang, J, Frydenberg, M, Moon, D, Morlacco, A, Kretschmer, A, Barletta, F, Heidegger, I, Tilki, D, van den Bergh, R, Dal Moro, F, Briganti, A, Montorsi, F, Novara, G, Gandaglia, G & EAU-YAU Prostate Cancer Working Group 2023, 'Is There an Impact of Transperineal Versus Transrectal Magnetic Resonance Imaging-targeted Biopsy on the Risk of Upgrading in Final Pathology in Prostate Cancer Patients Undergoing Radical Prostatectomy? An European Association of Urology-Young Academic Urologists Prostate Cancer Working Group Multi-institutional Study', EUR UROL FOCUS, vol. 9, no. 4, pp. 621-628. https://doi.org/10.1016/j.euf.2023.01.016

APA

Zattoni, F., Marra, G., Martini, A., Kasivisvanathan, V., Grummet, J., Harkin, T., Ploussard, G., Olivier, J., Chiu, P. K., Valerio, M., Marquis, A., Gontero, P., Guo, H., Zhuang, J., Frydenberg, M., Moon, D., Morlacco, A., Kretschmer, A., Barletta, F., ... EAU-YAU Prostate Cancer Working Group (2023). Is There an Impact of Transperineal Versus Transrectal Magnetic Resonance Imaging-targeted Biopsy on the Risk of Upgrading in Final Pathology in Prostate Cancer Patients Undergoing Radical Prostatectomy? An European Association of Urology-Young Academic Urologists Prostate Cancer Working Group Multi-institutional Study. EUR UROL FOCUS, 9(4), 621-628. https://doi.org/10.1016/j.euf.2023.01.016

Vancouver

Zattoni F, Marra G, Martini A, Kasivisvanathan V, Grummet J, Harkin T et al. Is There an Impact of Transperineal Versus Transrectal Magnetic Resonance Imaging-targeted Biopsy on the Risk of Upgrading in Final Pathology in Prostate Cancer Patients Undergoing Radical Prostatectomy? An European Association of Urology-Young Academic Urologists Prostate Cancer Working Group Multi-institutional Study. EUR UROL FOCUS. 2023 Jul;9(4):621-628. https://doi.org/10.1016/j.euf.2023.01.016

Bibtex

@article{9a30320a3fec4e149990e8812c47e5e9,
title = "Is There an Impact of Transperineal Versus Transrectal Magnetic Resonance Imaging-targeted Biopsy on the Risk of Upgrading in Final Pathology in Prostate Cancer Patients Undergoing Radical Prostatectomy? An European Association of Urology-Young Academic Urologists Prostate Cancer Working Group Multi-institutional Study",
abstract = "BACKGROUND: The concordance rates of transperineal (TP) versus transrectal (TR) prostate biopsies with radical prostatectomy (RP) specimen have been assessed poorly in men diagnosed with magnetic resonance imaging (MRI)-targeted biopsy (TBx).OBJECTIVE: To evaluate International Society of Urological Pathology (ISUP) concordance rates between the final pathology at RP and MRI-TBx or MRI-TBx + random biopsy (RB) according to the biopsy approach.DESIGN, SETTING, AND PARTICIPANTS: A multi-institutional database included patients diagnosed with TP or TR treated with RP.INTERVENTION: TP-TBx or TR-TBx of the prostate.OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: The ISUP grade at biopsy was compared with the final pathology. A multivariable logistic regression analysis (MVA) was performed to assess the association between the biopsy approach (TP-TBx vs TR-TBx) and ISUP upgrading, downgrading, concordance, and clinically relevant increase (CRI).RESULTS AND LIMITATIONS: Overall, 752 (59%) versus 530 (41%) patients underwent TR versus TP. At the MVA, TP-TBx was an independent predictor of upgrading (odds ratio [OR] 0.6, 95% confidence interval [CI] 0.4-0.9, p < 0.01) and improved concordance relative to the final pathology (OR 1.7, 95% CI 1.2-2.5, p < 0.01) after adjusting for age, cT stage, Prostate Imaging Reporting and Data System, number of targeted cores, prostate-specific antigen, and prostate volume. Moreover, TP-TBx was associated with a lower risk of CRI than TR-TBx (OR 0.7, p < 0.01). This held true when considering patients who underwent MRI-TBx + RB (OR 0.6, p < 0.01). The inclusion of men who had RP represents a potential selection bias.CONCLUSIONS: The adoption of TP-TBx compared with TR-TBx may reduce the risk of upgrading and improve the concordance of biopsy grade with the final pathology. The TP approach decreases the odds of CRI with improved patient selection for the correct active treatment.PATIENT SUMMARY: In this report, we evaluated whether transperineal (TP) targeted biopsy (TBx) may improve the concordance of clinically significant prostate cancer with the final pathology in comparison with transrectal (TR) TBx in a large worldwide population. We found that TP-TBx might increase concordance compared with TR-TBx. Adding random biopsies to target one increases accuracy; however, concordance with the final pathology is overall suboptimal even with the TP approach.",
author = "Fabio Zattoni and Giancarlo Marra and Alberto Martini and Veeru Kasivisvanathan and Jeremy Grummet and Timothy Harkin and Guillaume Ploussard and Jonathan Olivier and Chiu, {Peter K} and Massimo Valerio and Alessandro Marquis and Paolo Gontero and Hongqian Guo and Junlong Zhuang and Mark Frydenberg and Daniel Moon and Alessandro Morlacco and Alexander Kretschmer and Francesco Barletta and Isabel Heidegger and Derya Tilki and {van den Bergh}, Roderick and {Dal Moro}, Fabrizio and Alberto Briganti and Francesco Montorsi and Giacomo Novara and Giorgio Gandaglia and {EAU-YAU Prostate Cancer Working Group}",
note = "Copyright {\textcopyright} 2023 European Association of Urology. Published by Elsevier B.V. All rights reserved.",
year = "2023",
month = jul,
doi = "10.1016/j.euf.2023.01.016",
language = "English",
volume = "9",
pages = "621--628",
journal = "EUR UROL FOCUS",
issn = "2405-4569",
publisher = "Elsevier BV",
number = "4",

}

RIS

TY - JOUR

T1 - Is There an Impact of Transperineal Versus Transrectal Magnetic Resonance Imaging-targeted Biopsy on the Risk of Upgrading in Final Pathology in Prostate Cancer Patients Undergoing Radical Prostatectomy? An European Association of Urology-Young Academic Urologists Prostate Cancer Working Group Multi-institutional Study

AU - Zattoni, Fabio

AU - Marra, Giancarlo

AU - Martini, Alberto

AU - Kasivisvanathan, Veeru

AU - Grummet, Jeremy

AU - Harkin, Timothy

AU - Ploussard, Guillaume

AU - Olivier, Jonathan

AU - Chiu, Peter K

AU - Valerio, Massimo

AU - Marquis, Alessandro

AU - Gontero, Paolo

AU - Guo, Hongqian

AU - Zhuang, Junlong

AU - Frydenberg, Mark

AU - Moon, Daniel

AU - Morlacco, Alessandro

AU - Kretschmer, Alexander

AU - Barletta, Francesco

AU - Heidegger, Isabel

AU - Tilki, Derya

AU - van den Bergh, Roderick

AU - Dal Moro, Fabrizio

AU - Briganti, Alberto

AU - Montorsi, Francesco

AU - Novara, Giacomo

AU - Gandaglia, Giorgio

AU - EAU-YAU Prostate Cancer Working Group

N1 - Copyright © 2023 European Association of Urology. Published by Elsevier B.V. All rights reserved.

PY - 2023/7

Y1 - 2023/7

N2 - BACKGROUND: The concordance rates of transperineal (TP) versus transrectal (TR) prostate biopsies with radical prostatectomy (RP) specimen have been assessed poorly in men diagnosed with magnetic resonance imaging (MRI)-targeted biopsy (TBx).OBJECTIVE: To evaluate International Society of Urological Pathology (ISUP) concordance rates between the final pathology at RP and MRI-TBx or MRI-TBx + random biopsy (RB) according to the biopsy approach.DESIGN, SETTING, AND PARTICIPANTS: A multi-institutional database included patients diagnosed with TP or TR treated with RP.INTERVENTION: TP-TBx or TR-TBx of the prostate.OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: The ISUP grade at biopsy was compared with the final pathology. A multivariable logistic regression analysis (MVA) was performed to assess the association between the biopsy approach (TP-TBx vs TR-TBx) and ISUP upgrading, downgrading, concordance, and clinically relevant increase (CRI).RESULTS AND LIMITATIONS: Overall, 752 (59%) versus 530 (41%) patients underwent TR versus TP. At the MVA, TP-TBx was an independent predictor of upgrading (odds ratio [OR] 0.6, 95% confidence interval [CI] 0.4-0.9, p < 0.01) and improved concordance relative to the final pathology (OR 1.7, 95% CI 1.2-2.5, p < 0.01) after adjusting for age, cT stage, Prostate Imaging Reporting and Data System, number of targeted cores, prostate-specific antigen, and prostate volume. Moreover, TP-TBx was associated with a lower risk of CRI than TR-TBx (OR 0.7, p < 0.01). This held true when considering patients who underwent MRI-TBx + RB (OR 0.6, p < 0.01). The inclusion of men who had RP represents a potential selection bias.CONCLUSIONS: The adoption of TP-TBx compared with TR-TBx may reduce the risk of upgrading and improve the concordance of biopsy grade with the final pathology. The TP approach decreases the odds of CRI with improved patient selection for the correct active treatment.PATIENT SUMMARY: In this report, we evaluated whether transperineal (TP) targeted biopsy (TBx) may improve the concordance of clinically significant prostate cancer with the final pathology in comparison with transrectal (TR) TBx in a large worldwide population. We found that TP-TBx might increase concordance compared with TR-TBx. Adding random biopsies to target one increases accuracy; however, concordance with the final pathology is overall suboptimal even with the TP approach.

AB - BACKGROUND: The concordance rates of transperineal (TP) versus transrectal (TR) prostate biopsies with radical prostatectomy (RP) specimen have been assessed poorly in men diagnosed with magnetic resonance imaging (MRI)-targeted biopsy (TBx).OBJECTIVE: To evaluate International Society of Urological Pathology (ISUP) concordance rates between the final pathology at RP and MRI-TBx or MRI-TBx + random biopsy (RB) according to the biopsy approach.DESIGN, SETTING, AND PARTICIPANTS: A multi-institutional database included patients diagnosed with TP or TR treated with RP.INTERVENTION: TP-TBx or TR-TBx of the prostate.OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: The ISUP grade at biopsy was compared with the final pathology. A multivariable logistic regression analysis (MVA) was performed to assess the association between the biopsy approach (TP-TBx vs TR-TBx) and ISUP upgrading, downgrading, concordance, and clinically relevant increase (CRI).RESULTS AND LIMITATIONS: Overall, 752 (59%) versus 530 (41%) patients underwent TR versus TP. At the MVA, TP-TBx was an independent predictor of upgrading (odds ratio [OR] 0.6, 95% confidence interval [CI] 0.4-0.9, p < 0.01) and improved concordance relative to the final pathology (OR 1.7, 95% CI 1.2-2.5, p < 0.01) after adjusting for age, cT stage, Prostate Imaging Reporting and Data System, number of targeted cores, prostate-specific antigen, and prostate volume. Moreover, TP-TBx was associated with a lower risk of CRI than TR-TBx (OR 0.7, p < 0.01). This held true when considering patients who underwent MRI-TBx + RB (OR 0.6, p < 0.01). The inclusion of men who had RP represents a potential selection bias.CONCLUSIONS: The adoption of TP-TBx compared with TR-TBx may reduce the risk of upgrading and improve the concordance of biopsy grade with the final pathology. The TP approach decreases the odds of CRI with improved patient selection for the correct active treatment.PATIENT SUMMARY: In this report, we evaluated whether transperineal (TP) targeted biopsy (TBx) may improve the concordance of clinically significant prostate cancer with the final pathology in comparison with transrectal (TR) TBx in a large worldwide population. We found that TP-TBx might increase concordance compared with TR-TBx. Adding random biopsies to target one increases accuracy; however, concordance with the final pathology is overall suboptimal even with the TP approach.

U2 - 10.1016/j.euf.2023.01.016

DO - 10.1016/j.euf.2023.01.016

M3 - SCORING: Journal article

C2 - 36746729

VL - 9

SP - 621

EP - 628

JO - EUR UROL FOCUS

JF - EUR UROL FOCUS

SN - 2405-4569

IS - 4

ER -