Is there a natural limit of the transformation rate of oral leukoplakia?
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Is there a natural limit of the transformation rate of oral leukoplakia? / Scheifele, Christian; Reichart, Peter A.
In: ORAL ONCOL, Vol. 39, No. 5, 01.07.2003, p. 470-5.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Is there a natural limit of the transformation rate of oral leukoplakia?
AU - Scheifele, Christian
AU - Reichart, Peter A
PY - 2003/7/1
Y1 - 2003/7/1
N2 - Recent reviews described a cumulative risk of 0-38% of oral leukoplakias (OL) to transform into oral squamous cell carcinoma (OSCC). The annual transformation rate (ATR) of OL into OSCC amounted up to 6.3%. To elucidate epidemiological consequences of varying ATR. Variations of the prevalence (1-2%) and ATR (0.5-4%) of OL were used to compute the proportional incidences of OSCC developing in OL. These were compared to the actual incidences of OSCC excerpted from European cancer registries. A ratio <50% of predicted to actual incidence overall indicated a plausible ATR. With an ATR>or=3%, the predicted incidences of OSCC would exceed the reported incidences in all countries. With an ATR
AB - Recent reviews described a cumulative risk of 0-38% of oral leukoplakias (OL) to transform into oral squamous cell carcinoma (OSCC). The annual transformation rate (ATR) of OL into OSCC amounted up to 6.3%. To elucidate epidemiological consequences of varying ATR. Variations of the prevalence (1-2%) and ATR (0.5-4%) of OL were used to compute the proportional incidences of OSCC developing in OL. These were compared to the actual incidences of OSCC excerpted from European cancer registries. A ratio <50% of predicted to actual incidence overall indicated a plausible ATR. With an ATR>or=3%, the predicted incidences of OSCC would exceed the reported incidences in all countries. With an ATR
KW - Carcinoma, Squamous Cell/epidemiology
KW - Data Collection/methods
KW - Europe/epidemiology
KW - Female
KW - Humans
KW - Incidence
KW - Leukoplakia, Oral/epidemiology
KW - Male
U2 - 10.1016/s1368-8375(03)00006-x
DO - 10.1016/s1368-8375(03)00006-x
M3 - SCORING: Journal article
C2 - 12747971
VL - 39
SP - 470
EP - 475
JO - ORAL ONCOL
JF - ORAL ONCOL
SN - 1368-8375
IS - 5
ER -