Is multiple sclerosis progression associated with the HLA-DR15 haplotype?
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Is multiple sclerosis progression associated with the HLA-DR15 haplotype? / Stürner, Klarissa Hanja; Siembab, Inessa; Schön, Gerhard; Stellmann, Jan-Patrick; Heidari, Nika; Fehse, Boris; Heesen, Christoph; Eiermann, Thomas H; Martin, Roland; Binder, Thomas Mc.
In: Mult Scler J-Exp Transl Clin, Vol. 5, No. 4, 17.12.2019, p. 2055217319894615.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Is multiple sclerosis progression associated with the HLA-DR15 haplotype?
AU - Stürner, Klarissa Hanja
AU - Siembab, Inessa
AU - Schön, Gerhard
AU - Stellmann, Jan-Patrick
AU - Heidari, Nika
AU - Fehse, Boris
AU - Heesen, Christoph
AU - Eiermann, Thomas H
AU - Martin, Roland
AU - Binder, Thomas Mc
N1 - © The Author(s) 2019.
PY - 2019/12/17
Y1 - 2019/12/17
N2 - Background: The prevalence of multiple sclerosis is associated with the major histocompatibility complex class II DR15 haplotype HLA-DRB1*15:01∼HLA-DRB5*01:01.Objective: To assess whether multiple sclerosis progression is associated with the main susceptibility haplotype HLA-DRB1*15:01∼HLA-DRB5*01:01.Methods: Patients (n = 1230) and healthy controls (n = 2110) were genotyped for HLA-DRB1 and HLA-DRB5. The baseline Expanded Disability Status Scale (EDSS) score was determined and patients were followed for at least 3 years.Results: After follow-up of the consecutive cohort 349 patients were classified as having clinical isolated syndrome and 881 patients as having multiple sclerosis. The susceptibility allele HLA-DRB1*15:01 was more frequent in clinical isolated syndrome (odds ratio 1.56) and multiple sclerosis (odds ratio 3.17) compared to controls. HLA- DRB1*15:01 was the only enriched HLA-DRB1 allele in multiple sclerosis patients. Comparison of clinical characteristics between HLA-DRB1*15:01∼HLA-DRB5*01:01 negative and positive patients with multiple sclerosis showed that baseline EDSS score, disease duration and frequency of the category secondary progressive multiple sclerosis with relapse were increased in the HLA-DRB1*15:01∼HLA-DRB5*01:01 positive group.Conclusion: The study confirmed HLA-DRB1*15:01 and HLA-DRB5*01:01 as the main susceptibility alleles and showed weak indirect evidence for a role in progression of the disease.
AB - Background: The prevalence of multiple sclerosis is associated with the major histocompatibility complex class II DR15 haplotype HLA-DRB1*15:01∼HLA-DRB5*01:01.Objective: To assess whether multiple sclerosis progression is associated with the main susceptibility haplotype HLA-DRB1*15:01∼HLA-DRB5*01:01.Methods: Patients (n = 1230) and healthy controls (n = 2110) were genotyped for HLA-DRB1 and HLA-DRB5. The baseline Expanded Disability Status Scale (EDSS) score was determined and patients were followed for at least 3 years.Results: After follow-up of the consecutive cohort 349 patients were classified as having clinical isolated syndrome and 881 patients as having multiple sclerosis. The susceptibility allele HLA-DRB1*15:01 was more frequent in clinical isolated syndrome (odds ratio 1.56) and multiple sclerosis (odds ratio 3.17) compared to controls. HLA- DRB1*15:01 was the only enriched HLA-DRB1 allele in multiple sclerosis patients. Comparison of clinical characteristics between HLA-DRB1*15:01∼HLA-DRB5*01:01 negative and positive patients with multiple sclerosis showed that baseline EDSS score, disease duration and frequency of the category secondary progressive multiple sclerosis with relapse were increased in the HLA-DRB1*15:01∼HLA-DRB5*01:01 positive group.Conclusion: The study confirmed HLA-DRB1*15:01 and HLA-DRB5*01:01 as the main susceptibility alleles and showed weak indirect evidence for a role in progression of the disease.
U2 - 10.1177/2055217319894615
DO - 10.1177/2055217319894615
M3 - SCORING: Journal article
C2 - 31839982
VL - 5
SP - 2055217319894615
JO - Mult Scler J-Exp Transl Clin
JF - Mult Scler J-Exp Transl Clin
SN - 2055-2173
IS - 4
ER -