Is immediate bony microsurgical reconstruction after head and neck tumor ablation associated with a higher rate of local recurrence?

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Is immediate bony microsurgical reconstruction after head and neck tumor ablation associated with a higher rate of local recurrence? / Hanken, Henning; Wilkens, Ralf; Riecke, Björn; Al-Dam, Ahmed; Tribius, Silke; Kluwe, Lan; Smeets, Ralf; Heiland, Max; Eichhorn, Wolfgang; Gröbe, Alexander.

In: J CRANIO MAXILL SURG, Vol. 43, No. 3, 01.04.2015, p. 373-5.

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@article{f6876020ed504e4c9cb5f664a7d488e2,
title = "Is immediate bony microsurgical reconstruction after head and neck tumor ablation associated with a higher rate of local recurrence?",
abstract = "The purpose of this retrospective study was to examine the possible effect of immediate bony microvascular free flap reconstruction of mandibular defects after radical tumor resection of oral squamous cell carcinoma (OSCC) on the rate of local relapse. Our own data regarding recurrence rates for 1-step immediate reconstruction were compared to the published recurrence rates of 2-step reconstructions. A total of 21 patients (aged 45-77 years) with OSCC who underwent a primary surgical therapy with subsequent immediate bony microvascular free flap reconstruction of mandibular defects were followed up for 18-38 months. Four local relapses (19%) were recorded, all in patients with initial tumor stage of T4. Although intraoperative histological findings were R0 in all 21 cases, definitive histology later detected R1 status in the resected bone in 2 cases (10%). Immediate bony free flap reconstruction of mandibular defects after radical surgical resection of OSCC does not seem to increase the risk of local recurrence nor affect patient survival when compared with the 2-step surgical approach.",
author = "Henning Hanken and Ralf Wilkens and Bj{\"o}rn Riecke and Ahmed Al-Dam and Silke Tribius and Lan Kluwe and Ralf Smeets and Max Heiland and Wolfgang Eichhorn and Alexander Gr{\"o}be",
note = "Copyright {\textcopyright} 2015 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.",
year = "2015",
month = apr,
day = "1",
doi = "10.1016/j.jcms.2015.01.006",
language = "English",
volume = "43",
pages = "373--5",
journal = "J CRANIO MAXILL SURG",
issn = "1010-5182",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - Is immediate bony microsurgical reconstruction after head and neck tumor ablation associated with a higher rate of local recurrence?

AU - Hanken, Henning

AU - Wilkens, Ralf

AU - Riecke, Björn

AU - Al-Dam, Ahmed

AU - Tribius, Silke

AU - Kluwe, Lan

AU - Smeets, Ralf

AU - Heiland, Max

AU - Eichhorn, Wolfgang

AU - Gröbe, Alexander

N1 - Copyright © 2015 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

PY - 2015/4/1

Y1 - 2015/4/1

N2 - The purpose of this retrospective study was to examine the possible effect of immediate bony microvascular free flap reconstruction of mandibular defects after radical tumor resection of oral squamous cell carcinoma (OSCC) on the rate of local relapse. Our own data regarding recurrence rates for 1-step immediate reconstruction were compared to the published recurrence rates of 2-step reconstructions. A total of 21 patients (aged 45-77 years) with OSCC who underwent a primary surgical therapy with subsequent immediate bony microvascular free flap reconstruction of mandibular defects were followed up for 18-38 months. Four local relapses (19%) were recorded, all in patients with initial tumor stage of T4. Although intraoperative histological findings were R0 in all 21 cases, definitive histology later detected R1 status in the resected bone in 2 cases (10%). Immediate bony free flap reconstruction of mandibular defects after radical surgical resection of OSCC does not seem to increase the risk of local recurrence nor affect patient survival when compared with the 2-step surgical approach.

AB - The purpose of this retrospective study was to examine the possible effect of immediate bony microvascular free flap reconstruction of mandibular defects after radical tumor resection of oral squamous cell carcinoma (OSCC) on the rate of local relapse. Our own data regarding recurrence rates for 1-step immediate reconstruction were compared to the published recurrence rates of 2-step reconstructions. A total of 21 patients (aged 45-77 years) with OSCC who underwent a primary surgical therapy with subsequent immediate bony microvascular free flap reconstruction of mandibular defects were followed up for 18-38 months. Four local relapses (19%) were recorded, all in patients with initial tumor stage of T4. Although intraoperative histological findings were R0 in all 21 cases, definitive histology later detected R1 status in the resected bone in 2 cases (10%). Immediate bony free flap reconstruction of mandibular defects after radical surgical resection of OSCC does not seem to increase the risk of local recurrence nor affect patient survival when compared with the 2-step surgical approach.

U2 - 10.1016/j.jcms.2015.01.006

DO - 10.1016/j.jcms.2015.01.006

M3 - SCORING: Journal article

C2 - 25701393

VL - 43

SP - 373

EP - 375

JO - J CRANIO MAXILL SURG

JF - J CRANIO MAXILL SURG

SN - 1010-5182

IS - 3

ER -