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Is correction for age necessary in SPECT or PET of the central serotonin transporter in young, healthy adults?

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Is correction for age necessary in SPECT or PET of the central serotonin transporter in young, healthy adults? / Buchert, Ralph; Schulze, Oliver; Wilke, Florian; Berding, Georg; Thomasius, Rainer; Petersen, Kay; Brenner, Winfried; Clausen, Malte.

In: J NUCL MED, Vol. 47, No. 1, 1, 2006, p. 38-42.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Buchert, R, Schulze, O, Wilke, F, Berding, G, Thomasius, R, Petersen, K, Brenner, W & Clausen, M 2006, 'Is correction for age necessary in SPECT or PET of the central serotonin transporter in young, healthy adults?', J NUCL MED, vol. 47, no. 1, 1, pp. 38-42. <http://www.ncbi.nlm.nih.gov/pubmed/16391185?dopt=Citation>

APA

Buchert, R., Schulze, O., Wilke, F., Berding, G., Thomasius, R., Petersen, K., Brenner, W., & Clausen, M. (2006). Is correction for age necessary in SPECT or PET of the central serotonin transporter in young, healthy adults? J NUCL MED, 47(1), 38-42. [1]. http://www.ncbi.nlm.nih.gov/pubmed/16391185?dopt=Citation

Vancouver

Buchert R, Schulze O, Wilke F, Berding G, Thomasius R, Petersen K et al. Is correction for age necessary in SPECT or PET of the central serotonin transporter in young, healthy adults? J NUCL MED. 2006;47(1):38-42. 1.

Bibtex

@article{f952323c0d8c42968ace914bb5e3ba54,
title = "Is correction for age necessary in SPECT or PET of the central serotonin transporter in young, healthy adults?",
abstract = "PET and SPECT have suggested that there is an age-related decline of up to 10% per decade in the availability of brain serotonin transporter (SERT) in healthy subjects, starting as early as the age of 20 y. The aim of the present study was to verify these findings in young subjects. METHODS: The equilibrium specific-to-nonspecific partition coefficient V''(3) of the SERT ligand (11)C-(+)McN5652 was obtained for 29 healthy subjects aged 18-33 y. V''(3) was tested for age dependence by linear regression analysis using both a volumes-of-interest approach and voxel-based statistical parametric mapping. The sex of the subject and the season of year were considered nuisance variables. RESULTS: Age had no significant effect on V''(3). The power for the detection of an age-related decline in V''(3) of the magnitude reported previously was 0.917. CONCLUSION: These findings indicate that age is not a relevant confounding factor for SERT availability as measured by (11)C-(+)McN5652 PET in healthy adults up to the age of about 35 y.",
author = "Ralph Buchert and Oliver Schulze and Florian Wilke and Georg Berding and Rainer Thomasius and Kay Petersen and Winfried Brenner and Malte Clausen",
year = "2006",
language = "Deutsch",
volume = "47",
pages = "38--42",
journal = "J NUCL MED",
issn = "0161-5505",
publisher = "Society of Nuclear Medicine Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - Is correction for age necessary in SPECT or PET of the central serotonin transporter in young, healthy adults?

AU - Buchert, Ralph

AU - Schulze, Oliver

AU - Wilke, Florian

AU - Berding, Georg

AU - Thomasius, Rainer

AU - Petersen, Kay

AU - Brenner, Winfried

AU - Clausen, Malte

PY - 2006

Y1 - 2006

N2 - PET and SPECT have suggested that there is an age-related decline of up to 10% per decade in the availability of brain serotonin transporter (SERT) in healthy subjects, starting as early as the age of 20 y. The aim of the present study was to verify these findings in young subjects. METHODS: The equilibrium specific-to-nonspecific partition coefficient V''(3) of the SERT ligand (11)C-(+)McN5652 was obtained for 29 healthy subjects aged 18-33 y. V''(3) was tested for age dependence by linear regression analysis using both a volumes-of-interest approach and voxel-based statistical parametric mapping. The sex of the subject and the season of year were considered nuisance variables. RESULTS: Age had no significant effect on V''(3). The power for the detection of an age-related decline in V''(3) of the magnitude reported previously was 0.917. CONCLUSION: These findings indicate that age is not a relevant confounding factor for SERT availability as measured by (11)C-(+)McN5652 PET in healthy adults up to the age of about 35 y.

AB - PET and SPECT have suggested that there is an age-related decline of up to 10% per decade in the availability of brain serotonin transporter (SERT) in healthy subjects, starting as early as the age of 20 y. The aim of the present study was to verify these findings in young subjects. METHODS: The equilibrium specific-to-nonspecific partition coefficient V''(3) of the SERT ligand (11)C-(+)McN5652 was obtained for 29 healthy subjects aged 18-33 y. V''(3) was tested for age dependence by linear regression analysis using both a volumes-of-interest approach and voxel-based statistical parametric mapping. The sex of the subject and the season of year were considered nuisance variables. RESULTS: Age had no significant effect on V''(3). The power for the detection of an age-related decline in V''(3) of the magnitude reported previously was 0.917. CONCLUSION: These findings indicate that age is not a relevant confounding factor for SERT availability as measured by (11)C-(+)McN5652 PET in healthy adults up to the age of about 35 y.

M3 - SCORING: Zeitschriftenaufsatz

VL - 47

SP - 38

EP - 42

JO - J NUCL MED

JF - J NUCL MED

SN - 0161-5505

IS - 1

M1 - 1

ER -