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Iron uptake in the brain of the myelin-deficient rat.

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Iron uptake in the brain of the myelin-deficient rat. / Gocht, Andreas; Keith, A B; Candy, J M; Morris, C M.

In: NEUROSCI LETT, Vol. 154, No. 1-2, 1-2, 1993, p. 187-190.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Gocht, A, Keith, AB, Candy, JM & Morris, CM 1993, 'Iron uptake in the brain of the myelin-deficient rat.', NEUROSCI LETT, vol. 154, no. 1-2, 1-2, pp. 187-190. <http://www.ncbi.nlm.nih.gov/pubmed/8361638?dopt=Citation>

APA

Gocht, A., Keith, A. B., Candy, J. M., & Morris, C. M. (1993). Iron uptake in the brain of the myelin-deficient rat. NEUROSCI LETT, 154(1-2), 187-190. [1-2]. http://www.ncbi.nlm.nih.gov/pubmed/8361638?dopt=Citation

Vancouver

Gocht A, Keith AB, Candy JM, Morris CM. Iron uptake in the brain of the myelin-deficient rat. NEUROSCI LETT. 1993;154(1-2):187-190. 1-2.

Bibtex

@article{6c066da12fe24de8b32172232162c40d,
title = "Iron uptake in the brain of the myelin-deficient rat.",
abstract = "The role of oligodendrocyte-derived transferrin in the transport and regional accumulation of iron has been studied in myelin-deficient (md) rats, which lack functional oligodendrocytes and have an almost complete depletion of transferrin in the brain, although they have normal peripheral levels of transferrin. The regional uptake of 59Fe into the brain has been studied autoradiographically in md and littermate control rats. Differences in uptake were found in only three of the 28 regions studied. These results suggest that the uptake and distribution of iron is not impaired in the md rat despite a markedly reduced level of brain transferrin. The choroid plexus contains high levels of transferrin mRNA and it is therefore likely that transferrin synthesized by choroid plexus epithelial cells can mediate the transport of iron within the brain.",
author = "Andreas Gocht and Keith, {A B} and Candy, {J M} and Morris, {C M}",
year = "1993",
language = "Deutsch",
volume = "154",
pages = "187--190",
journal = "NEUROSCI LETT",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "1-2",

}

RIS

TY - JOUR

T1 - Iron uptake in the brain of the myelin-deficient rat.

AU - Gocht, Andreas

AU - Keith, A B

AU - Candy, J M

AU - Morris, C M

PY - 1993

Y1 - 1993

N2 - The role of oligodendrocyte-derived transferrin in the transport and regional accumulation of iron has been studied in myelin-deficient (md) rats, which lack functional oligodendrocytes and have an almost complete depletion of transferrin in the brain, although they have normal peripheral levels of transferrin. The regional uptake of 59Fe into the brain has been studied autoradiographically in md and littermate control rats. Differences in uptake were found in only three of the 28 regions studied. These results suggest that the uptake and distribution of iron is not impaired in the md rat despite a markedly reduced level of brain transferrin. The choroid plexus contains high levels of transferrin mRNA and it is therefore likely that transferrin synthesized by choroid plexus epithelial cells can mediate the transport of iron within the brain.

AB - The role of oligodendrocyte-derived transferrin in the transport and regional accumulation of iron has been studied in myelin-deficient (md) rats, which lack functional oligodendrocytes and have an almost complete depletion of transferrin in the brain, although they have normal peripheral levels of transferrin. The regional uptake of 59Fe into the brain has been studied autoradiographically in md and littermate control rats. Differences in uptake were found in only three of the 28 regions studied. These results suggest that the uptake and distribution of iron is not impaired in the md rat despite a markedly reduced level of brain transferrin. The choroid plexus contains high levels of transferrin mRNA and it is therefore likely that transferrin synthesized by choroid plexus epithelial cells can mediate the transport of iron within the brain.

M3 - SCORING: Zeitschriftenaufsatz

VL - 154

SP - 187

EP - 190

JO - NEUROSCI LETT

JF - NEUROSCI LETT

SN - 0304-3940

IS - 1-2

M1 - 1-2

ER -